eXPRESS Polymer Letters,
Journal Year:
2023,
Volume and Issue:
18(2), P. 160 - 192
Published: Dec. 6, 2023
Polymer-based
hydrogels
are
hydrophilic
polymer
networks
with
a
remarkable
capacity
to
absorb
substantial
amounts
of
water
and
biological
fluids,
rendering
them
highly
attractive
for
drug
delivery
applications.The
COVID-19
pandemic
has
acted
as
catalyst
research
innovation
in
the
realm
polymer-based
delivery,
particular
emphasis
on
antiviral
therapeutics,
vaccines,
diagnostics,
precision
respiratory
system.The
distinctive
attributes
hydrogels,
such
their
biocompatibility,
customizable
release
profiles,
ease
functionalization,
establish
versatile
platforms
development
advanced
systems
combat
not
only
but
also
spectrum
other
infectious
diseases.This
study
is
dedicated
scruti-nizing
evaluating
characteristics
employed
treatment
diseases
associated
SARS-CoV-2
virus.Furthermore,
investigation
introduces
novel
classification
system
deployed
SARS-CoV-2-related
diseases.Additionally,
paper
provides
an
up-to-date
evaluation
latest
developed
utilized
dis-eases
linked
virus,
based
conducted
through
recent
months
2023.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 6, 2023
Abstract
Skin
cancer
is
a
global
threat
to
the
healthcare
system
and
estimated
incline
tremendously
in
next
20
years,
if
not
diagnosed
at
an
early
stage.
Even
though
it
curable
stage,
novel
drug
identification,
clinical
success,
resistance
another
major
challenge.
To
bridge
gap
bring
effective
treatment,
important
understand
etiology
of
skin
carcinoma,
mechanism
cell
proliferation,
factors
affecting
growth,
resistance.
The
current
article
focusses
on
understanding
structural
diversity
cancers,
treatments
available
till
date
including
phytocompounds,
chemotherapy,
radiotherapy,
photothermal
therapy,
surgery,
combination
molecular
targets
associated
with
growth
metastasis,
special
emphasis
nanotechnology-based
approaches
for
downregulating
deleterious
disease.
A
detailed
analysis
respect
types
nanoparticles
their
scope
overcoming
multidrug
as
well
trials
has
been
discussed.
Graphical
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
97, P. 102315 - 102315
Published: April 26, 2024
Lung
cancer
stands
as
the
primary
contributor
to
cancer-related
fatalities
worldwide,
affecting
both
genders.
Two
types
exist
where
non-small
cell
lung
(NSCLC),
accounts
for
80–85%
and
SCLC
10-15%
of
cases.
NSCLC
subtypes
include
adenocarcinoma,
squamous
carcinoma,
large
carcinoma.
Smoking,
second-hand
smoke,
radon
gas,
asbestos,
other
pollutants,
genetic
predisposition,
COPD
are
risk
factors.
On
hand,
stresses
such
DNA
damage,
telomere
shortening,
oncogene
activation
cause
a
prolonged
cycle
halt,
known
senescence.
Despite
its
initial
role
tumor-suppressing
mechanism
that
slows
growth,
excessive
or
improper
control
this
process
can
age-related
diseases,
including
cancer.
Cellular
senescence
has
two
purposes
in
Researchers
report
tumor
growth
by
constraining
multiplication
impaired
cells.
However,
senescent
cells
also
demonstrate
pro-inflammatory
senescence-associated
secretory
phenotype
(SASP),
which
is
widely
reported
promote
This
review
will
look
at
cellular
cancer,
describe
diagnostic
markers,
ask
about
current
treatments
it,
case
studies
clinical
trials
show
how
senescence-targeting
therapies
be
used
talk
problems
currently
being
faced,
possible
solutions
same
future.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
655, P. 124046 - 124046
Published: March 29, 2024
Typical
antibiotic
treatments
are
often
ineffectual
against
biofilm-related
infections
since
bacteria
residing
within
biofilms
have
developed
various
mechanisms
to
resist
antibiotics.
To
overcome
these
limitations,
antimicrobial-loaded
liposomal
nanoparticles
a
promising
anti-biofilm
strategy
as
they
demonstrated
improved
delivery
and
eradication
of
in
biofilms.
Antibiotic-loaded
revealed
remarkably
higher
antibacterial
activities
than
free
drugs
experimental
settings.
Moreover,
can
be
used
efficaciously
for
the
combinational
antibiotics
other
antimicrobial
compounds/peptide
which
facilitate,
instance,
significant
breakdown
biofilm
matrix,
increased
bacterial
elimination
from
depletion
metabolic
activity
pathogens.
Drug-loaded
liposomes
mitigated
recurrent
considered
tool
address
challenges
associated
resistance.
Furthermore,
it
has
been
that
surface
charge
polyethylene
glycol
modification
notable
impact
on
their
activity.
Future
investigations
should
tackle
persistent
hurdles
with
development
safe
effective
clinical
application
investigate
novel
treatments,
including
CRISPR-Cas
gene
editing,
natural
compounds,
phages,
nano-mediated
approaches.
Herein,
we
emphasize
significance
inhibition
biofilms,
challenges,
recent
advances,
future
perspectives.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Oct. 31, 2024
Chitosan
nanoparticles
(NPs)
are
well-recognized
as
promising
vehicles
for
delivering
anticancer
drugs
due
to
their
distinctive
characteristics.
They
have
the
potential
enclose
hydrophobic
molecules,
thereby
enhancing
solubilities,
permeabilities,
and
bioavailabilities;
without
use
of
surfactant,
i.e.,
through
surfactant-free
solubilization.
This
allows
higher
drug
concentrations
at
tumor
sites,
prevents
excessive
toxicity
imparted
by
surfactants,
could
circumvent
resistance.
Moreover,
biomedical
engineers
formulation
scientists
can
also
fabricate
chitosan
NPs
slowly
release
agents.
keeps
site
longer,
makes
therapy
more
effective,
lowers
frequency
dosing.
Notably,
some
types
cancer
cells
(fallopian
tube,
epithelial
tumors
ovary,
primary
peritoneum;
lung,
kidney,
ependymal
brain,
uterus,
breast,
colon,
malignant
pleural
mesothelioma)
overexpression
folate
receptors
(FRs)
on
outer
surface,
which
lets
folate-drug
conjugate–incorporated
target
kill
them
effectively.
Strikingly,
there
is
evidence
suggesting
that
excessively
produced
FR&αgr
(isoforms
FR)
stays
consistent
throughout
treatment
in
ovarian
endometrial
cancer,
indicating
resistance
conventional
treatment;
this
regard,
folate-anchored
overcome
it
improve
therapeutic
outcomes.
Interestingly,
overly
expressed
FRs
present
only
certain
types,
a
biomarker
predicting
effectiveness
FR-targeted
therapy.
On
other
hand,
folate-modified
enhance
oral
absorption
medicines,
especially
drugs,
pave
way
effective
long-term
low-dose
metronomic
scheduling
poorly
soluble
permeable
drugs.
In
review,
we
talked
briefly
about
techniques
used
create,
characterize,
tailor
chitosan-based
NPs;
delved
deeper
into
applications
folate-engineered
treating
various
types.
Schematic
illustration
ligand-drug
incorporated
its
advantage
cancer.
Figure
created
with
BioRender.Com.
European Polymer Journal,
Journal Year:
2024,
Volume and Issue:
215, P. 113243 - 113243
Published: July 1, 2024
Osteoarthritis
(OA)
is
a
well-known
degenerative
joint
disease
recognized
by
the
deterioration
of
cartilage
in
joints,
leading
to
pain
and
reduced
mobility.
Traditional
treatments
for
OA
include
management,
physical
therapy,
severe
cases,
replacement
surgery.
In
recent
years,
there
has
been
growing
interest
exploring
potential
phytoconstituents
nanomedicines
combined
treating
OA.
Furthermore,
with
increasing
amount
study
this
field,
now
opportune
time
widespread
use
plant-derived
medications
as
complementary
alternative
medical
therapies
be
acknowledged
used
more
efficient
treatment
human
ailments
like
Combining
nanomedicine
technology
(phyto-nanomedicine)
can
potentially
enhance
their
effectiveness
The
phyto-nanomedicines
many
advantages,
including
enhanced
permeability,
increased
bioavailability,
sustained/controlled
drug
release
at
site,
decreased
adverse
effects,
possible
combination
treatment.
It's
important
note
that
while
promising
preclinical
some
clinical
evidence
regarding
phyto-nanomedicine
treatment,
further
research
needed
establish
safety
efficacy
conclusively.
review,
treat
combining
phytomedicines
nanoparticulate
delivery
former
therapeutic
discussed
detail.
we
have
also
described
briefly
on
application
organ-on-chip
and/or
on-chip
models
accelerate
identification
novel
evaluate
potency
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
94, P. 105517 - 105517
Published: Feb. 28, 2024
Lower
respiratory
tract
infections
(LRTIs)
are
inherited
disorders
which
often
causes
chronic
for
patients
repeatedly
receive
oral
antibiotics,
particularly
during
periods
of
worsened
lung
symptoms.
However,
the
existing
treatment
modalities
unable
to
completely
clear
responsible
pathogens,
contributes
emergence
antimicrobial
resistance
(AMR).
To
circumvent
these
issues,
direct
delivery
antibiotics
infected
cells
by
inhalation
is
emerging
as
a
preferred
strategy.
More
importantly,
antibiotic-loaded
inhalable
liposomal
nanoparticles
(ALILNPs)
an
attractive
option
efficient
management
LRTIs
such
cystic
fibrosis
(CF),
obstructive
pulmonary
disease
(COPD),
and
bronchiectasis.
ALILNPs
have
demonstrated
significantly
higher
antibacterial
efficacy
in
both
preclinical
clinical
settings.
Furthermore,
several
studies
reported
that
inhaled
show
sustained
enhancements
function
amelioration
forced
expiratory
volume
1
s
(FEV1)
depletion
P.
aeruginosa
density.
Liposome
considered
safe
administering
range
improve
remedial
effectiveness
incorporated
agents
diminish
drug
toxicity.
Toxicity
aspects
liposomes
are,
however,
still
not
abundantly
reported.
Thus,
there
exists
compelling
requirement
development
vitro
or
vivo
models
gain
insights
into
safety
within
system.
Although,
impact
on
macrophages
biofilms
arising
from
well
established,
full
potential
formulations
yet
be
realised.
Herein,
we
discuss
challenges,
recent
advances,
future
perspectives
various
pathogens
associated
with
LRTIs.
