An update of the impact of pesticide exposure on memory and learning DOI Creative Commons
Karol Ferreira Honatel, Bruno Dutra Arbo, Mirna Bainy Leal

и другие.

Deleted Journal, Год журнала: 2024, Номер 1(1)

Опубликована: Ноя. 11, 2024

The dependence on the use of pesticides in agribusiness leads to an increase human exposure these chemical compounds through occupational activity, contamination environment, food and water. nervous system is target most insecticidal when are poorly selective, they can harm non-target species, including humans. This work aimed investigate effects pesticide memory learning. Articles published PubMed database between 2015 2024 were reviewed. One hundred sixty-one articles included this review, which one thirty two preclinical studies twenty-nine studies. Among studies, organophosphates, pyrethroids, neonicotinoids, carbamates, addition herbicides, fungicides mixed exposures was associated with learning deficits animals such as bees, mosquitoes, fishes, mice, rats, bats. Olfactory, associative aversive learning, well capacity affected by pesticides. Most evaluated environmental organophosphate pesticides, pyrethroids carbamates outcomes interest. Living close application areas having parents working agriculture worse scores childhood adolescence. Prenatal insecticides has already been poorer attention skills attention-deficit/hyperactivity disorder (ADHD) symptoms, intellectual disability, autism spectrum disorder, motor delays, problems. In adults, during activity also performance. evidence found review suggests that different mechanisms action able cause some cognitive impairment. Developmental exposure, chronic contribute performance, especially memory.

Язык: Английский

Dual-recognition “turn-off-on” fluorescent Biosensor triphenylamine-based continuous detection of copper ion and glyphosate applicated in environment and living system DOI

Ya-Tong Liu,

Qianqian Zhang,

Si-Yi Yao

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 477, С. 135216 - 135216

Опубликована: Июль 23, 2024

Язык: Английский

Процитировано

17
Urinary glyphosate, selenium status, and their impact on mortality: Evidence from NHANES 2013–2018 DOI Creative Commons
Pei‐Lun Chu, Ching-Chung Hsiao, Ta‐Chen Su

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117989 - 117989

Опубликована: Март 1, 2025

Glyphosate and glyphosate-based herbicides (GBHs), extensively used worldwide, have been associated with various health concerns, including an elevated risk of mortality. Experimental studies suggest that these may disrupt selenium homeostasis by hindering its uptake or promoting oxidative stress. However, the interplay between glyphosate exposure status remains poorly understood in epidemiological studies, particularly regarding selenium's role modulating mortality nationally representative populations. In this study, we analyzed data from 2013-2018 National Health Nutrition Examination Survey (NHANES), which included 6410 participants aged 3 years older. This dataset was linked to information Center for Statistics (NCHS) individuals 18 older, follow-up through 2019. The primary aim investigate relationships urinary levels, whole blood selenium, intake, influence on glyphosate-related all-cause risk. A significant negative correlation observed natural logarithm (ln) levels ln complex multiple linear regression models, a ß coefficient -0.010 (SE = 0.003, P 0.003). no association found intake. Furthermore, prominent among females, non-Hispanic whites, lower When examining relationship exposure, mortality, higher ln-urinary were significantly increased (Hazard Ratio [HR] 1.43; 95 % CI: 1.00-2.09). especially pronounced concentrations at above 50th percentile. Additionally, ln-whole protective effect against (HR 0.01; 0.00-0.18), strongest below comprehensive analysis NHANES data, our study identifies potentially harmful levels. Notably, excessively high not only reduce effects but could also increase suggesting U-shaped These findings highlight need further research into interaction status, emphasizing potential public implications.

Язык: Английский

Процитировано

2
Association between glyphosate exposure and osteoarthritis in US adults: Especially in people who are obese and inactive in leisure time physical activity DOI
Zhuoshuai Liang,

Xiaoyue Sun,

Ruifang Guo

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 927, С. 172008 - 172008

Опубликована: Март 26, 2024

Язык: Английский

Процитировано

7
Associations between environmental glyphosate exposure and glucose homeostasis indices in US general adults: a national population-based cross-sectional study DOI Creative Commons
Xiaobin Feng, Min Wang, Yuji Wang

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 10, 2025

As glyphosate's application becomes increasingly widespread across the globe, its potential adverse effects on humans have garnered growing concerns. Little evidence has revealed associations between glyphosate and glucose homeostasis. A total of 2094 individuals were recruited from NHANES 2013–2018. Urinary glyphosate, alkaline phosphatase (ALP), fasting plasma (FPG), insulin, glycated hemoglobin A1c (HbA1c) measured. Homeostatic model assessment beta-cell function (HOMA2-β), insulin resistance (HOMA2-IR), sensitivity (HOMA2-IS) assessed. Generalized linear models mediation analyses fitted to estimate homeostasis, ALP. demonstrated a statistically significant positive association with FPG HbA1c in dose–response manner, while showing negative HOMA2-β. Each doubling increase urinary was associated 1.13%, 1.50%, − 2.80% alteration FPG, HbA1c, HOMA2-β, respectively. Obesity modified dyshomeostasis stronger obese individuals. In addition, elevated ALP significantly mediated proportions 9.91% 20.23%, Environmental exposure dyshomeostasis, which more pronounced partly by

Язык: Английский

Процитировано

1
Association between ethylene oxide exposure and cognitive function in older adults from NHANES data DOI Creative Commons
Meng Sun, Meng Cai, Sisi Sun

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 28, 2025

Язык: Английский

Процитировано

1
Serum neurofilament light chain and cognition decline in US elderly: A cross‐sectional study DOI Creative Commons
X. Liu, Jun Chen,

Chen Meng

и другие.

Annals of Clinical and Translational Neurology, Год журнала: 2023, Номер 11(1), С. 17 - 29

Опубликована: Окт. 30, 2023

Abstract Objective Early identification of cognitive impairment in neurodegenerative diseases like Alzheimer's disease (AD) is crucial. Neurofilament, a potential biomarker for neurological disorders, has gained attention. Our study aims to investigate the relationship between serum neurofilament light (sNfL) levels and function elderly individuals United States. Methods This cross‐sectional analyzed data from participants aged 60 above National Health Nutrition Examination Survey (2013–2014). We collected sNfL levels, tests, sociodemographic characteristics, comorbidities, other variables. Weighted multiple linear regression models examined ln(sNfL) scores. Restricted cubic spline (RCS) visualization explored nonlinear relationships. The stratified analysis subgroups' association. Results included 446 (47.73% male). Participants with 2.58 2.81 pg/mL (second quintile) performed relatively well tests. After adjusting factors, were negatively correlated function, adjusted β (95% CI) as follows: immediate recall test (IRT): −0.763 (−1.301 −0.224), delayed (DRT): −0.308 (−0.576 −0.04), animal fluency (AFT): −1.616 (−2.639 −0.594), digit symbol substitution (DSST): −2.790 (−4.369 −1.21). RCS curves showed relationships DRT, AFT, inflection points around 2.7 pg/mL. revealed negative correlation cognition specific subgroups distinct features, an interaction diabetes ln(sNfL). Interpretation Higher are associated poorer population shows promise early decline.

Язык: Английский

Процитировано

10
BMI-mediated association between glyphosate exposure and increased risk of atherosclerotic heart disease: A large-scale cross-sectional study DOI Creative Commons

Wendi Xu,

Zhe Chen,

yuhong jiang

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0317908 - e0317908

Опубликована: Янв. 24, 2025

Background Glyphosate, as the main component of glyphosate pesticides, has been shown to have toxic effects on multiple human systems. However, association between and atherosclerotic cardiovascular disease (ASCVD) remains unclear. This study aims explore effect exposure ASCVD. Methods involved 1,602 participants employed various statistical techniques, such multivariable logistic regression, linear fitting, mediation analysis, subgroup sensitivity elucidate diseases. Results Compared with low level exposure, risk ASCVD increased significantly high (OR = 2.05, 95%CI 1.17–3.58, p<0.05, p for trend<0.05), which showed a upward trend. Further analysis found that levels angina pectoris 2.84, 1.00–8.04, coronary heart 3.76, 1.80–7.83, p<0.01, attack 2.65, 1.35–5.23, trend 0.09) were associated. Mediating BMI mediated ASCVD, an indirect 0.002405(95%CI: 0.000182–0.01, 0.02) direct 0.039336(95%CI: 0.000391–0.09), total 0.041741(95%CI: 0.002112–0.10). Conclusion Increased is associated plays mediating role in this association. In addition, higher angina, disease, attack.

Язык: Английский

Процитировано

0
Experimental Design of Polymer Synthesis for the Removal of 2,4-Dichlorophenoxyacetic Acid and Glyphosate from Water by Adsorption DOI Creative Commons
Tiago Teixeira Alves, Grasiele Soares Cavallini, Nelson Luís Gonçalves Dias de Souza

и другие.

Waste, Год журнала: 2025, Номер 3(1), С. 7 - 7

Опубликована: Фев. 22, 2025

Water pollution from herbicide contamination poses a significant environmental challenge, necessitating effective regenerative materials for their removal. 2,4-dichlorophenoxyacetic acid and glyphosate are among the most widely used herbicides weed control. This study aimed to synthesize polymeric removal of these compounds aqueous media. The evaluated adsorption capacity, isotherms, kinetics, regeneration influence pH on adsorption, alongside disinfection tests. Biodegradable polymers including chitosan, sodium alginate, guar gum were cross-linked characterized using infrared Raman spectroscopy. Two samples (experiment C M) exhibited capacities 49.75 ± 1.474 mg g−1 26.53 1.326 acid, respectively. Optimal was observed at 3.00 6.00 acid. Langmuir Dubinin–Radushkevich isotherms best described behavior Kinetic studies indicated that process followed pseudo-second-order model. Infrared absorption spectra confirmed cross-linking in polymer samples. Regeneration tests showed remained consistent over three reuse cycles, while increased. Disinfection Escherichia coli total coliforms demonstrated reduction colony-forming units, supporting suitability material this application.

Язык: Английский

Процитировано

0
Associations between urinary glyphosate and arthritis: an US NHANES analysis DOI Creative Commons

Xiaoyao He,

Liangyu Mi,

Miaomiao Zhao

и другие.

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Март 13, 2025

Objective As the relationship between urine glyphosate and arthritis in adults general is still unclear, study set out to investigate it. Methods A total of 1,689 people volunteered National Health Nutrition Examination Surveys (US NHANES). Utilizing a multivariate logistic regression model explore association concentrations (both continuous with categorical) risks developing arthritis, as well various types arthritis. Non-linear correlations have been investigated using restricted cubic spline smooth curve fitting. We also conducted additional subgroup analyses categorical defining features. Results Patients had levels 0.4 ng/mL, while non-arthritic individuals 0.3 ng/mL ( p &lt; 0.05). After adjusting for confounding variables, models demonstrated significant positive elevated urinary risk [1.2 (1.0, 1.4)]. This was observed osteoarthritis (OA) subgroup, an odds ratio 1.3 (95% CI: 1.1, 1.6), but not found rheumatoid (RA) or other subgroups. Smooth fitting RCS further elucidate that exhibit dose-dependent both OA, adhering linear trend (with -value nonlinearity exceeding Subsequent studies showed certain groups people, remained significant. Conclusion Increased exposure may be associated particularly osteoarthritis.

Язык: Английский

Процитировано

0
Associations of prenatal glyphosate exposure with child neurodevelopment in a Canadian pregnancy cohort study DOI Creative Commons

Meaghan Hall,

Jillian Ashley‐Martin, Christine Till

и другие.

Environment International, Год журнала: 2025, Номер 199, С. 109480 - 109480

Опубликована: Апрель 17, 2025

Glyphosate is the most widely used pesticide worldwide. Few epidemiologic studies have examined potential for neurotoxicity by glyphosate or its degradate, Aminomethylphosphonic Acid (AMPA). We associations of maternal urinary and AMPA concentrations with child cognitive, social, behavioural functioning in participants enrolled Maternal-Infant Research on Environmental Chemicals (MIREC) study. Maternal were measured first trimester spot urine samples. assessed children's cognition (IQ) at 3-4 years age (n = 572) using Wechsler Preschool Primary Scale Intelligence-III. Social 566) 840) parent-report versions Responsiveness Scale-2 Behavioral Assessment System Children-2. quantified between neurodevelopmental outcomes multivariable linear regression models effect modification sex, folic acid, plasma folate. Median (IQR) 0.31 (0.33) μg/L 0.25 (0.25) μg/L. not significantly associated social functioning, there was no evidence modification. found a non-significant inverse trend Performance IQ (B -0.85; 95 %CI: -1.71,0.01). In this primarily urban cohort Canadian mother-child pairs, prenatal exposure neurodevelopment. Further evaluation as developmental neurotoxicant study multiple samples per participant higher levels warranted.

Язык: Английский

Процитировано

0