Dual-recognition “turn-off-on” fluorescent Biosensor triphenylamine-based continuous detection of copper ion and glyphosate applicated in environment and living system

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 477, P. 135216 - 135216

Published: July 23, 2024

Language: Английский

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Association between glyphosate exposure and osteoarthritis in US adults: Especially in people who are obese and inactive in leisure time physical activity

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172008 - 172008

Published: March 26, 2024

Language: Английский

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Associations between environmental glyphosate exposure and glucose homeostasis indices in US general adults: a national population-based cross-sectional study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 10, 2025

As glyphosate's application becomes increasingly widespread across the globe, its potential adverse effects on humans have garnered growing concerns. Little evidence has revealed associations between glyphosate and glucose homeostasis. A total of 2094 individuals were recruited from NHANES 2013–2018. Urinary glyphosate, alkaline phosphatase (ALP), fasting plasma (FPG), insulin, glycated hemoglobin A1c (HbA1c) measured. Homeostatic model assessment beta-cell function (HOMA2-β), insulin resistance (HOMA2-IR), sensitivity (HOMA2-IS) assessed. Generalized linear models mediation analyses fitted to estimate homeostasis, ALP. demonstrated a statistically significant positive association with FPG HbA1c in dose–response manner, while showing negative HOMA2-β. Each doubling increase urinary was associated 1.13%, 1.50%, − 2.80% alteration FPG, HbA1c, HOMA2-β, respectively. Obesity modified dyshomeostasis stronger obese individuals. In addition, elevated ALP significantly mediated proportions 9.91% 20.23%, Environmental exposure dyshomeostasis, which more pronounced partly by

Language: Английский

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BMI-mediated association between glyphosate exposure and increased risk of atherosclerotic heart disease: A large-scale cross-sectional study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317908 - e0317908

Published: Jan. 24, 2025

Background Glyphosate, as the main component of glyphosate pesticides, has been shown to have toxic effects on multiple human systems. However, association between and atherosclerotic cardiovascular disease (ASCVD) remains unclear. This study aims explore effect exposure ASCVD. Methods involved 1,602 participants employed various statistical techniques, such multivariable logistic regression, linear fitting, mediation analysis, subgroup sensitivity elucidate diseases. Results Compared with low level exposure, risk ASCVD increased significantly high (OR = 2.05, 95%CI 1.17–3.58, p<0.05, p for trend<0.05), which showed a upward trend. Further analysis found that levels angina pectoris 2.84, 1.00–8.04, coronary heart 3.76, 1.80–7.83, p<0.01, attack 2.65, 1.35–5.23, trend 0.09) were associated. Mediating BMI mediated ASCVD, an indirect 0.002405(95%CI: 0.000182–0.01, 0.02) direct 0.039336(95%CI: 0.000391–0.09), total 0.041741(95%CI: 0.002112–0.10). Conclusion Increased is associated plays mediating role in this association. In addition, higher angina, disease, attack.

Language: Английский

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Association between ethylene oxide exposure and cognitive function in older adults from NHANES data

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 28, 2025

Language: Английский

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Experimental Design of Polymer Synthesis for the Removal of 2,4-Dichlorophenoxyacetic Acid and Glyphosate from Water by Adsorption

Waste, Journal Year: 2025, Volume and Issue: 3(1), P. 7 - 7

Published: Feb. 22, 2025

Water pollution from herbicide contamination poses a significant environmental challenge, necessitating effective regenerative materials for their removal. 2,4-dichlorophenoxyacetic acid and glyphosate are among the most widely used herbicides weed control. This study aimed to synthesize polymeric removal of these compounds aqueous media. The evaluated adsorption capacity, isotherms, kinetics, regeneration influence pH on adsorption, alongside disinfection tests. Biodegradable polymers including chitosan, sodium alginate, guar gum were cross-linked characterized using infrared Raman spectroscopy. Two samples (experiment C M) exhibited capacities 49.75 ± 1.474 mg g−1 26.53 1.326 acid, respectively. Optimal was observed at 3.00 6.00 acid. Langmuir Dubinin–Radushkevich isotherms best described behavior Kinetic studies indicated that process followed pseudo-second-order model. Infrared absorption spectra confirmed cross-linking in polymer samples. Regeneration tests showed remained consistent over three reuse cycles, while increased. Disinfection Escherichia coli total coliforms demonstrated reduction colony-forming units, supporting suitability material this application.

Language: Английский

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Urinary glyphosate, selenium status, and their impact on mortality: Evidence from NHANES 2013–2018

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117989 - 117989

Published: March 1, 2025

Glyphosate and glyphosate-based herbicides (GBHs), extensively used worldwide, have been associated with various health concerns, including an elevated risk of mortality. Experimental studies suggest that these may disrupt selenium homeostasis by hindering its uptake or promoting oxidative stress. However, the interplay between glyphosate exposure status remains poorly understood in epidemiological studies, particularly regarding selenium's role modulating mortality nationally representative populations. In this study, we analyzed data from 2013-2018 National Health Nutrition Examination Survey (NHANES), which included 6410 participants aged 3 years older. This dataset was linked to information Center for Statistics (NCHS) individuals 18 older, follow-up through 2019. The primary aim investigate relationships urinary levels, whole blood selenium, intake, influence on glyphosate-related all-cause risk. A significant negative correlation observed natural logarithm (ln) levels ln complex multiple linear regression models, a ß coefficient -0.010 (SE = 0.003, P 0.003). no association found intake. Furthermore, prominent among females, non-Hispanic whites, lower When examining relationship exposure, mortality, higher ln-urinary were significantly increased (Hazard Ratio [HR] 1.43; 95 % CI: 1.00-2.09). especially pronounced concentrations at above 50th percentile. Additionally, ln-whole protective effect against (HR 0.01; 0.00-0.18), strongest below comprehensive analysis NHANES data, our study identifies potentially harmful levels. Notably, excessively high not only reduce effects but could also increase suggesting U-shaped These findings highlight need further research into interaction status, emphasizing potential public implications.

Language: Английский

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Associations between urinary glyphosate and arthritis: an US NHANES analysis

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 13, 2025

Objective As the relationship between urine glyphosate and arthritis in adults general is still unclear, study set out to investigate it. Methods A total of 1,689 people volunteered National Health Nutrition Examination Surveys (US NHANES). Utilizing a multivariate logistic regression model explore association concentrations (both continuous with categorical) risks developing arthritis, as well various types arthritis. Non-linear correlations have been investigated using restricted cubic spline smooth curve fitting. We also conducted additional subgroup analyses categorical defining features. Results Patients had levels 0.4 ng/mL, while non-arthritic individuals 0.3 ng/mL ( p &lt; 0.05). After adjusting for confounding variables, models demonstrated significant positive elevated urinary risk [1.2 (1.0, 1.4)]. This was observed osteoarthritis (OA) subgroup, an odds ratio 1.3 (95% CI: 1.1, 1.6), but not found rheumatoid (RA) or other subgroups. Smooth fitting RCS further elucidate that exhibit dose-dependent both OA, adhering linear trend (with -value nonlinearity exceeding Subsequent studies showed certain groups people, remained significant. Conclusion Increased exposure may be associated particularly osteoarthritis.

Language: Английский

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Associations of prenatal glyphosate exposure with child neurodevelopment in a Canadian pregnancy cohort study

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109480 - 109480

Published: April 1, 2025

Language: Английский

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Glyphosate Induces Anxiety‐Like Behaviors in Mice via Activating NLRP3‐Mediated Hippocampal Microglia Pyroptosis

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

ABSTRACT Glyphosate is reported to compromise the central nervous system and induce behavioral disorders in mammals. However, evidence deficient with respect potential mechanisms involved. In this study, C57BL/6 mice were orally exposed glyphosate at doses ranging from 0 200 mg/kg/day for 16 weeks. The results of tests showed that decreased time spent distance traveled within area open field test, retention number entries into arms, increased close arms elevated plus maze test. expressions anxiety‐related genes htr5 , htr6 tmem132d also significantly upregulated by glyphosate. This phenotype was linked permeation brain via disrupting functional tight junctions blood–brain barrier (BBB). As a result, directly compromised morphological structure neurons, IBA‐1 microglia, activated expression NLRP3‐mediated pyroptosis pathway (NLRP3, Caspase‐1, GSDMD, IL‐18) hippocampus mice. Moreover, glyphosate‐induced activation NLRP3 microglia markedly reversed inhibitor MCC950. conditional mediums glyphosate‐treated BV2 cells aggravated cytotoxicity HT‐22 which rescued conclusion, work demonstrated microglia‐mediated plays detrimental role glyphosate‐behavioral neuron damage. These findings provide novel neurotoxicity support growing association between exposure neurobehavioral humans.

Language: Английский

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