Redox Report, Год журнала: 2024, Номер 29(1)
Опубликована: Дек. 5, 2024
Background Diabetic cataract (DC) is a major cause of blindness, with its pathogenesis involving oxidative stress and ferroptosis, according to recent studies.
Язык: Английский
Poultry Science, Год журнала: 2024, Номер 103(9), С. 104011 - 104011
Опубликована: Июнь 22, 2024
Exposure to copper (Cu) has been associated with metabolic disorders in animals and humans, but the underlying mechanism remains unclear. One-day-old broiler chickens, numbering a total of 192, were nourished dietary intakes that contained varying concentrations Cu, specifically 11, 110, 220, 330 mg/kg for period extending over duration 7 wk. As result study, Cu exposure resulted vacuolization, fragmentation mitochondria cristae, increase autophagosomes hepatocytes. Metabolomics analysis illustrated caused 59 different metabolites liver, predominantly glycerophospholipid pathway, leading disruption. Moreover, high-Cu diet markedly reduced levels AMPKα1, p-AMPKα1, mTOR, p-mTOR enhanced expression autophagy-related factors (Atg5, Dynein, Beclin1, LC3-II). Overall, chicken liver injury disturbed processes mediated autophagy primarily through AMPK-mTOR axis.
Язык: Английский
Процитировано
20
Metabolites, Год журнала: 2024, Номер 14(1), С. 71 - 71
Опубликована: Янв. 22, 2024
Ecological theories suggest that environmental factors significantly influence obesity risk and related syndemic morbidities, including metabolically abnormal associated with nonalcoholic fatty liver disease (MASLD). These encompass anthropogenic influences endocrine-disrupting chemicals (EDCs), synergistically interacting to induce metabolic discrepancies, notably in early life, disrupt processes adulthood. This review focuses on endocrine disruptors affecting a child’s MASLD risk, independent of their role as obesogens thus regardless impact adipogenesis. The plays pivotal detoxification processes, where various lipophilic molecules accumulate parenchyma, exacerbating inflammation functioning new anthropogenics perpetuate chronic low-grade inflammation, especially insulin resistance, crucial the pathogenesis MASLD.
Язык: Английский
Процитировано
14
The Science of The Total Environment, Год журнала: 2024, Номер 926, С. 172018 - 172018
Опубликована: Март 27, 2024
Язык: Английский
Процитировано
12
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142696 - 142696
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Archives of Public Health, Год журнала: 2024, Номер 82(1)
Опубликована: Март 27, 2024
Abstract Heavy metals’ presence as environmental pollutants has a close link to adverse health effects. Frailty, clinical syndrome hallmarked by elevated vulnerability stressors, presents substantial challenge in healthcare. However, the association between exposure heavy metals and frailty largely remains unexplored. Utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 2003–2018 correlated with U.S. Death Index (NDI) 2019, we investigated mortality outcomes. Logistic regression, Cox Kaplan-Meier survival curves, weighted quantile-sum (WQS) Bayesian kernel machine regression (BKMR) were employed assess metal incidence frail population. Eight measured urine using inductively coupled plasma mass spectrometry values adjusted for urinary creatinine, which was used reflect exposure. The cohort incorporated 5370 female participants aged 45 above, 1518 diagnosed frailty. findings indicated correlation specific metals, namely tungsten (odds ratio [OR]: 1.94, 95% confidence interval [CI]: 1.31–2.89), cobalt (OR: 1.64, CI: 1.40–1.93), cadmium 1.93, 1.52–2.43), uranium 7.36, 1.53–35.28), an risk of WQS BKMR models identified cadmium, cobalt, main contributors analysis, after adjustment covariates, suggested that higher levels lead, death patients, associated hazard ratios (HR) 1.96 (1.53, 2.52) 1.30 (1.13, 1.49), respectively. Our study revealed significant positive mixtures onset middle-aged older adults, along increased patients. Cobalt, emerged prominent frailty, directly impacting long-term life expectancy
Язык: Английский
Процитировано
6
Pharmacological Research, Год журнала: 2024, Номер 205, С. 107251 - 107251
Опубликована: Июнь 12, 2024
Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes chronic worldwide. Epidemiological studies have reported that exposure population to environmental endocrine-disrupting chemicals (EDCs) associated with NAFLD. However, EDCs are different types, and there inconsistencies in relevant evidence descriptions, which not been systematically summarized so far. Therefore, this study aimed determine association between Three databases, including PubMed, Web science, Embase were searched, 27 articles included study. Methodological quality, heterogeneity, publication bias assessed using Newcastle-Ottawa scale, I
Язык: Английский
Процитировано
6
Environmental Research, Год журнала: 2024, Номер unknown, С. 120092 - 120092
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
6
Environmental Science & Technology, Год журнала: 2025, Номер 59(1), С. 268 - 278
Опубликована: Янв. 2, 2025
Arsenic (As) is a toxic metalloid widespread in the environment, and its exposure has been associated with variety of adverse health outcomes. As demonstrated to cause nonalcoholic fatty liver disease (NAFLD), underlying epigenetic mechanisms remain largely unknown. This study aimed investigate roles histone modifications low-level exposure-induced NAFLD rats. The results showed that caused lipid accumulation upregulated expression metabolism-related genes Fabp1, Srebf1, Apoc3, while downregulated Acox1 Cpt1a rat liver. In addition, it was found inorganic arsenite (iAsIII) methylated DMA, S-adenosylmethionine (SAM) level decreased, which would contribute repression H3K9me1/2 after exposure. vitro studies revealed SAM supplementation attenuated by restoring HepG2 cells, further confirmed our animal results. Therefore, suggested methylation depleted SAM, inhibited activated Apoc3 expressions, leading upon Overall, these data shed new light on role SAM-mediated As-triggered NAFLD, could be useful for prevention intervention hepatotoxicity induced environmental
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 30, 2025
Abstract Liver disease poses a significant threat to global public health, with arsenic (As) recognized as major environmental toxin contributing liver injury. However, the specific mechanisms and protective effects of α‐lipoic acid (LA) remain unclear. Therefore, this study employs network toxicology pharmacology comprehensively analyze hepatotoxic mechanism As hepatoprotective LA, further verifies peroxisomal β‐oxidation lipophagy in process. The analysis results show that induces damage mainly through autophagy, apoptosis, lipid metabolism, oxidative stress, whereas LA exerts its properties by regulating metabolism. Further verifications find inhibits SIRT1 expression, activates P53 Notch pathways, damages mitochondria, β‐oxidation, increases accumulation, enhances liver, while intervention alleviates As‐induced accumulation targeting SIRT1, ameliorating mitochondrial damage, enhancing thereby alleviating damage. This clarifies hepatotoxicity provides theoretical basis for potential agent.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141035 - 141035
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0