BMC Bioinformatics,
Год журнала:
2024,
Номер
25(1)
Опубликована: Апрель 29, 2024
Abstract
Many
important
biological
facts
have
been
found
as
single-cell
RNA
sequencing
(scRNA-seq)
technology
has
advanced.
With
the
use
of
this
technology,
it
is
now
possible
to
investigate
connections
among
individual
cells,
genes,
and
illnesses.
For
analysis
data,
clustering
frequently
used.
Nevertheless,
data
usually
contain
a
large
amount
noise
traditional
methods
are
sensitive
noise.
However,
acquiring
higher-order
spatial
information
from
alone
insufficient.
As
result,
getting
trustworthy
findings
challenging.
We
propose
Cauchy
hyper-graph
Laplacian
non-negative
matrix
factorization
(CHLNMF)
unique
approach
address
these
issues.
In
CHLNMF,
we
replace
measurement
based
on
Euclidean
distance
in
conventional
(NMF),
which
can
lessen
influence
noise,
with
loss
function
(CLF).
The
model
also
incorporates
constraint,
takes
into
account
high-order
link
samples.
CHLNMF
model's
best
solution
then
discovered
using
half-quadratic
optimization
approach.
Finally,
seven
scRNA-seq
datasets,
contrast
technique
other
nine
top
methods.
validity
our
was
established
by
experimental
outcomes.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 1001 - 1001
Опубликована: Янв. 13, 2024
Globally,
cardiovascular
diseases
(CVDs)
are
the
leading
cause
of
death
and
disability.
While
there
many
therapeutic
alternatives
available
for
management
CVDs,
majority
classic
strategies
were
found
to
be
ineffective
at
stopping
or
significantly/additionally
slowing
progression
these
diseases,
they
had
unfavorable
side
effects.
Numerous
metal-based
nanoparticles
(NPs)
have
been
created
overcome
limitations,
demonstrating
encouraging
possibilities
in
treatment
CVDs
due
advancements
nanotechnology.
Metallic
nanomaterials,
including
gold,
silver,
iron,
come
various
shapes,
sizes,
geometries.
NPs
generally
smaller
more
specialized
physical,
chemical,
biological
properties.
Metal-based
may
forms,
such
as
nanoshells,
nanorods,
nanospheres,
studied
most.
Massive
potential
applications
metal
nanomaterial
structures
include
supporting
molecular
imaging,
serving
drug
delivery
systems,
enhancing
radiation-based
anticancer
therapy,
supplying
photothermal
transforming
effects
thermal
being
compounds
with
bactericidal,
fungicidal,
antiviral
qualities
that
helpful
diseases.
In
this
context,
present
paper
aims
review
relevant
oxide
creating
an
up-to-date
framework
aids
researchers
developing
efficient
strategies.
Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
208, С. 115302 - 115302
Опубликована: Апрель 3, 2024
Cardiovascular
diseases
(CVDs)
stand
as
the
leading
cause
of
death
worldwide,
posing
a
significant
global
health
challenge.
Consequently,
development
innovative
therapeutic
strategies
to
enhance
CVDs
treatment
is
imperative.
RNA-based
therapies,
encompassing
non-coding
RNAs,
mRNA,
aptamers,
and
CRISPR/Cas9
technology,
have
emerged
promising
tools
for
addressing
CVDs.
However,
inherent
challenges
associated
with
RNA,
such
poor
cellular
uptake,
susceptibility
RNase
degradation,
capture
by
reticuloendothelial
system,
underscore
necessity
combining
these
therapies
effective
drug
delivery
systems.
Various
non-viral
systems,
including
extracellular
vesicles,
lipid-based
carriers,
polymeric
inorganic
nanoparticles,
well
hydrogels,
shown
promise
in
enhancing
efficacy
RNA
therapeutics.
In
this
review,
we
offer
an
overview
most
relevant
explored
emphasize
pivotal
role
systems
augmenting
their
effectiveness.
Additionally,
discuss
current
status
that
hinder
clinical
translation.
Deleted Journal,
Год журнала:
2024,
Номер
unknown, С. 01 - 10
Опубликована: Июль 19, 2024
The
growing
interest
in
nanoparticles
modern
research
is
due
to
their
potential
uses
different
fields
of
study.
Throughout
human
history,
individuals
have
been
exposed
environmental
nanosized
particles,
and
over
the
past
century,
these
exposures
significantly
risen.
Through
injection,
ingestion,
inhalation,
can
change
material's
physicochemical
characteristics
improve
its
ability
absorb
interact
with
biological
tissues.
Nanoparticles
penetrate
cell
membrane
reach
up
mitochondria
nucleus,
causing
gene
mutation
inhibiting
mitochondrial
process
involved
metabolism.
toxicity
associated
size,
shape,
charge,
surface
area,
chemical
composition,
other
linked
factors.
vivo
behavior
still
a
major
question
that
needs
be
resolved.
tests
are
performed
against
new
during
developmental
eliminate
or
ameliorate
identified
toxic
characteristics.
Royal Society of Chemistry eBooks,
Год журнала:
2025,
Номер
unknown, С. 30 - 82
Опубликована: Май 7, 2025
Magnetic
nanoparticles
(MNPs)
can
have
their
surfaces
modified
to
customize
functions
and
properties
for
a
range
of
uses.
In
order
achieve
multifunctionality,
this
chapter
thoroughly
analyzes
the
methods
tactics
used
alter
functionalize
MNPs.
Surface
modification
is
examined
in
context
fundamental
elements
MNPs,
such
as
synthesis
techniques
magnetic
behavior.
The
benefits
drawbacks
several
surface
methods,
including
coating,
ligand
exchange,
silanization,
polymer
grafting,
are
explained.
Furthermore,
functionalization
strategies
environmental
biological
applications,
emphasizing
attachment
medicinal
agents,
adsorbents,
imaging
probes,
targeting
ligands.
For
scholars
practitioners
who
intrigued
by
design
optimization
MNPs
various
provides
thorough
reference.
The Journal of Cardiovascular Aging,
Год журнала:
2025,
Номер
5(2)
Опубликована: Май 8, 2025
This
review
aims
to
summarize
the
current
landscape
of
cardiac
arrhythmia
therapeutics
and
highlight
recent
advances
in
nanoparticle-based
strategies
for
treatment
various
human
arrhythmias.
A
comprehensive
literature
was
conducted
curate
synthesize
preclinical
developments
nanoparticle-mediated
therapies
targeting
Cardiac
arrhythmias
represent
one
most
prevalent
challenging
forms
cardiovascular
disease
worldwide.
Conventional
treatments,
including
antiarrhythmic
drugs,
are
often
limited
by
suboptimal
efficacy,
high
recurrence
rates,
significant
off-target
toxicities.
While
catheter-based
ablation
techniques
have
emerged
as
alternative
interventions,
their
long-term
success
remains
inconsistent,
highlighted
outcomes
from
large
trials
such
CABANA
trial.
In
response
these
limitations,
interventions
a
promising
class
therapeutics.
These
offer
potential
advantages,
site-specific
drug
delivery,
reduced
systemic
toxicity,
novel
approaches
both
pharmacologic
ablative
therapy.
presents
an
overview
emerging
atrial
fibrillation
other
It
also
discusses
proof-of-concept
studies,
evaluates
benefits
limitations
nanoparticle
formulations,
outlines
key
challenges
future
directions
translating
technologies
into
clinical
practice.
