Cardiovascular Toxicology, Год журнала: 2024, Номер 24(11), С. 1287 - 1300

Опубликована: Авг. 30, 2024

Cardiovascular diseases are a rampant public health threat. Environmental contaminants, such as Cadmium (Cd), toxic metal, risk factors for cardiovascular diseases. Given that human exposure to Cd is increasing, there need therapies ameliorate toxicity. Selenium (Se), an essential trace element, has been proposed rescue the effects of toxicity, with mixed effects. Se's narrow therapeutic window necessitates precise dosing avoid Here, we assessed various waterborne and Se concentrations sequences on cardiac function using zebrafish (Danio rerio). We showed induced pericardial edemas modified heart rates in larvae concentration-dependent manner. To identify range Cd-induced cardiotoxicity, embryos were treated 0, 10, 50, 100, 150, or 200 μg/L 1-4 days prior 2.5 5 Cd. found 50 µg/L pre-treatment before Cd, but not reduced prevalence ameliorated bradycardia zebrafish. Zebrafish exposed 10 up 4 typical morphology, whereas other Se-exposed control fish presented edemas. Longer durations led fewer incidences Overall, this study highlights importance optimizing periods harness its protective against cardiotoxicity. These findings provide insights into potential strategies reducing Cd-related damage humans.

Язык: Английский