Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio) DOI Creative Commons
Rachael M. Heuer, Priscila Falagan-Lotsch, Jessica Okutsu

et al.

Cardiovascular Toxicology, Journal Year: 2024, Volume and Issue: 24(11), P. 1287 - 1300

Published: Aug. 30, 2024

Cardiovascular diseases are a rampant public health threat. Environmental contaminants, such as Cadmium (Cd), toxic metal, risk factors for cardiovascular diseases. Given that human exposure to Cd is increasing, there need therapies ameliorate toxicity. Selenium (Se), an essential trace element, has been proposed rescue the effects of toxicity, with mixed effects. Se's narrow therapeutic window necessitates precise dosing avoid Here, we assessed various waterborne and Se concentrations sequences on cardiac function using zebrafish (Danio rerio). We showed induced pericardial edemas modified heart rates in larvae concentration-dependent manner. To identify range Cd-induced cardiotoxicity, embryos were treated 0, 10, 50, 100, 150, or 200 μg/L 1-4 days prior 2.5 5 Cd. found 50 µg/L pre-treatment before Cd, but not reduced prevalence ameliorated bradycardia zebrafish. Zebrafish exposed 10 up 4 typical morphology, whereas other Se-exposed control fish presented edemas. Longer durations led fewer incidences Overall, this study highlights importance optimizing periods harness its protective against cardiotoxicity. These findings provide insights into potential strategies reducing Cd-related damage humans.

Language: Английский

Swimming Into View: Zebrafish Uncover Targets, Mechanisms, and Therapies for Cadmium Toxicity DOI Creative Commons
Jessica Okutsu, Md Imran Noor, Delia S. Shelton

et al.

Current Environmental Health Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: April 22, 2025

Language: Английский

Citations

0
Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio) DOI
Rachael M. Heuer, Priscila Falagan-Lotsch, Jessica Okutsu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Cardiovascular diseases are a rampant public health threat. Environmental contaminants, such as Cadmium (Cd), toxic metal, have been linked to increased risk for cardiovascular diseases. Given that human exposure Cd is increasing overtime, there need develop new therapies ameliorate toxicity. Selenium (Se), an essential trace element, has proposed rescue the effects of toxicity, with mixed effects. Se's narrow therapeutic window necessitates precise dosing avoid Here, we assessed various waterborne and Se concentrations sequences on cardiac function using zebrafish (

Language: Английский

Citations

1
Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio) DOI Creative Commons
Rachael M. Heuer, Priscila Falagan-Lotsch, Jessica Okutsu

et al.

Cardiovascular Toxicology, Journal Year: 2024, Volume and Issue: 24(11), P. 1287 - 1300

Published: Aug. 30, 2024

Cardiovascular diseases are a rampant public health threat. Environmental contaminants, such as Cadmium (Cd), toxic metal, risk factors for cardiovascular diseases. Given that human exposure to Cd is increasing, there need therapies ameliorate toxicity. Selenium (Se), an essential trace element, has been proposed rescue the effects of toxicity, with mixed effects. Se's narrow therapeutic window necessitates precise dosing avoid Here, we assessed various waterborne and Se concentrations sequences on cardiac function using zebrafish (Danio rerio). We showed induced pericardial edemas modified heart rates in larvae concentration-dependent manner. To identify range Cd-induced cardiotoxicity, embryos were treated 0, 10, 50, 100, 150, or 200 μg/L 1-4 days prior 2.5 5 Cd. found 50 µg/L pre-treatment before Cd, but not reduced prevalence ameliorated bradycardia zebrafish. Zebrafish exposed 10 up 4 typical morphology, whereas other Se-exposed control fish presented edemas. Longer durations led fewer incidences Overall, this study highlights importance optimizing periods harness its protective against cardiotoxicity. These findings provide insights into potential strategies reducing Cd-related damage humans.

Language: Английский

Citations

0