Journal of Biomaterials Science Polymer Edition,
Год журнала:
2023,
Номер
34(15), С. 2124 - 2143
Опубликована: Июнь 27, 2023
Collagen
plays
an
important
role
in
hemostasis
and
tissue
repair
processes.
Traditional
passive
wound
dressings
like
gauze,
bandage,
cotton
wool
could
hardly
fit
the
open
wounds
exerted
no
active
effect
on
healing.
Even
worse,
they
would
adhere
to
skin
tissue,
causing
dehydration
second
injury
upon
replacement.
Polyester
is
commonly
used
medical
field
a
safe
inexpensive
polymer.
Due
hydrophobic
surface,
polyester
does
not
tissue;
however,
have
hemostatic
properties.
We
designed
material
composed
of
collagen
polyester,
encapsulated
hydrolyzed
particles,
made
collagen-polyester
non-woven
fabric
by
melt
blowing
method,
The
content
was
1%
dressing
exhibited
nature,
preventing
moisture
from
sticking
its
surface.
purpose
this
study
compare
nonwovens
with
conventional
pads,
observe
adhesion
pads
wound.
healing
shrinkage
rates
were
compared
rat
test.
test
showed
that
containing
significantly
shortened
bleeding
time
traditional
retained
hydrophobicity
non-adhesion
had
better
angiogenesis
granulation
degree
than
control
group
14th
day,
reduced
rate.
excellent
hemostasis,
regeneration,
reduction
non-adhering
for
wounds.
Overall,
novel
collagen-containing
ideal
choice
dressings.
Aloe
vera-based
hydrogels
have
emerged
as
promising
platforms
for
the
delivery
of
therapeutic
agents
in
wound
dressings
due
to
their
biocompatibility
and
unique
wound-healing
properties.
The
present
study
provides
a
comprehensive
overview
recent
advances
application
healing.
synthesis
methods,
structural
characteristics,
properties
are
discussed.
Mechanisms
released
from
hydrogels,
including
diffusion,
swelling,
degradation,
also
analyzed.
In
addition,
effects
on
healing,
well
reduction
inflammation,
antimicrobial
activity,
tissue
regeneration,
highlighted.
incorporation
various
agents,
such
anti-inflammatory
ones,
into
is
reviewed
detail.
Furthermore,
challenges
future
prospects
dressing
applications
considered.
This
review
valuable
information
current
status
highlights
potential
improve
healing
outcomes.
Pharmaceutics,
Год журнала:
2024,
Номер
16(1), С. 93 - 93
Опубликована: Янв. 10, 2024
Wounds
and
chronic
wounds
can
be
caused
by
bacterial
infections
lead
to
discomfort
in
patients.
To
solve
this
problem,
scientists
are
working
create
modern
wound
dressings
with
antibacterial
additives,
mainly
because
traditional
materials
cannot
meet
the
general
requirements
for
complex
promote
healing.
This
demand
is
met
material
engineering,
through
which
we
electrospun
dressings.
Electrospun
dressings,
as
well
those
based
on
hydrogels
incorporated
compounds,
these
requirements.
manuscript
reviews
recent
used
discussing
their
formation,
application,
functionalization.
The
focus
presenting
hydrogels.
In
contrast,
advancements
care
have
highlighted
potential
of
thermoresponsive
dynamic
These
contain
adaptable
polymers
that
offer
targeted
drug
delivery
show
promise
managing
various
types
while
addressing
infections.
way,
article
intended
serve
a
compendium
knowledge
researchers,
medical
practitioners,
biomaterials
engineers,
providing
up-to-date
information
state
art,
possibilities
innovative
solutions,
challenges
area
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
657, С. 124136 - 124136
Опубликована: Апрель 19, 2024
Increasing
prevalence
of
infected
and
chronic
wounds
demands
improved
therapy
options.
In
this
work
an
electrospun
nanofiber
dressing
with
liposomes
is
suggested,
focusing
on
the
dressing's
ability
to
support
tissue
regeneration
infection
control.
Chloramphenicol
(CAM)
was
chosen
antibiotic,
added
nanofibers
after
first
embedded
in
maintain
a
sustained
drug
release.
Nanofibers
spun
from
five
different
polymer
blends
were
tested,
where
pectin
polyethylene
oxide
(PEO)
identified
as
most
promising
blend,
showing
superior
fiber
formation
tensile
strength.
The
wire-electrospinning
setup
(WES)
selected
for
its
pilot-scale
features,
water
applied
only
solvent
green
electrospinning
allow
direct
liposome
incorporation.
CAM-liposomes
Pectin-PEO
next
step.
Confocal
imaging
rhodamine-labelled
indicated
intact
fibers
electrospinning.
This
supported
by
observed
vitroCAM-release,
that
Pectin-PEO-nanofibers
had
delayed
release
compared
controls.
Biological
testing
confirmed
antimicrobial
efficacy
CAM
good
biocompatibility
all
CAM-nanofibers.
successful
production
process
WES
gives
outlook
industrial
upscaling.
