Cellulose
nanocrystals
(CNCs)
were
synthesized
from
jute
fiber
by
acid
hydrolysis
method.
Our
research
aims
to
fabricate
cellulose
reinforced
methyl
(MC)
and
chitosan
(CH)
bio-nanocomposites
(BNCs)
loaded
with
ketorolac
tromethamine
(KT)
drug.
The
BNC
films
fabricated
solvent
evaporation
technique.
We
have
investigated
the
chemical
structure,
morphology
mechanical
properties
of
formulations
using
Fourier
transform
infrared
(FTIR)
spectroscopy,
X-ray
diffraction
(XRD),
Universal
testing
machine
(UTM),
dynamic
light
scattering
(DLS),
contact
angle
(CA)
scanning
electron
microscopy
(SEM).
CNCs
BNCs
showed
excellent
material
property
which
may
a
broad
vista
in
realistic
biomedical
application.
Journal of Biomedical Materials Research Part B Applied Biomaterials,
Год журнала:
2025,
Номер
113(1)
Опубликована: Янв. 1, 2025
A
new
method
is
developed
using
elastic
lipid
nanovesicles
(ELNs)
loaded
with
ethanolic
extract
of
Lantana
camara
(LC)
to
enhance
skin
permeation
plant
actives.
The
ELNs
contained
cholesterol,
1,
2-distearoyl-sn-glycero-3-phosphocholine,
span
80,
and
tween
80.
Firstly,
15
formulations
were
produced
examine
critical
factors
likely
affecting
formulation
characteristics.
In
addition,
surface
characteristics,
vesicle
size,
polydispersity
index,
zeta
potential,
degree
deformability,
%
entrapment
efficiency
(%
EE)
ELN
examined.
As
a
significant
parameter,
was
measured
(using
Start-M;
it
highly
resembles
human
skin).
influence
hydrophilic-lipophilic
balance
(HLB),
ratio
vital
through
Start-M.
particular,
the
LC
decreased
at
more
extensive
size
ranges,
400,
350-450
nm.
contrast,
increased
significantly
smaller
such
as
200
100
More
than
75%
permeated
within
8
h
when
surfactant
(span
80:tween
80;
25%:75%).
Permeation
studies
conducted
based
on
HLB
values
revealed
that
78%
in
12.2,
an
increase
HLB.
Cell
viability
assay
SK-MEL-37
cells
(skin
cancer)
reduced
by
~80%
24
h,
further
validating
formulation.
Future
research
could
investigate
long-term
safety
therapeutic
potential
these
clinical
settings
their
effectiveness
delivering
other
plant-based
extracts
for
transdermal
applications
via
ELNs.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 209 - 209
Опубликована: Фев. 4, 2025
This
study
conducted
a
literature
review
by
searching
for
articles
related
to
the
treatment
of
skin
infections/wrinkles
using
nano-delivery
systems
containing
natural
compounds.
The
search
was
in
various
databases
published
last
10
years,
with
strict
inclusion
and
exclusion
criteria.
Of
490
found,
40
were
considered
relevant.
Acne
vulgaris
is
common
dermatological
disorder
characterised
inflammation
sebaceous
glands,
often
resulting
development
pimples,
cysts,
scarring.
Conventional
treatments,
including
antibiotics
topical
retinoids,
frequently
demonstrate
limitations
such
as
side
effects,
resistance,
insufficient
absorption.
Recent
advancements
nanotechnology
have
enabled
creation
innovative
drug-delivery
that
enhance
effectiveness
reduce
adverse
effects
anti-acne
medications.
Polyphenols
flavonoids,
bioactive
compounds
notable
anti-inflammatory,
antioxidant,
antibacterial
properties,
are
recognised
their
therapeutic
acne
treatment.
However,
practical
application
hindered
solubility,
stability,
bioavailability.
incorporation
these
into
nanoparticle-based
delivery
has
shown
promise
resolving
challenges.
Various
nanoparticle
platforms,
lipid-based
nanoparticles,
polymeric
solid
lipid
evaluated
ability
improve
controlled
release,
targeted
polyphenols
flavonoids
skin.
advent
polyphenol
flavonoid-loaded
nanoparticles
marks
new
therapy
era.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 4321 - 4337
Опубликована: Май 1, 2024
Cannabidiol
(CBD)
is
a
promising
therapeutic
drug
with
low
addictive
potential
and
favorable
safety
profile.
However,
CBD
did
face
certain
challenges,
including
poor
solubility
in
water
oral
bioavailability.
To
harness
the
of
by
combining
it
transdermal
delivery
system
(TDDS).
This
innovative
approach
sought
to
develop
patch
dosage
form
micellar
vesicular
nanocarriers
enhance
bioavailability
CBD,
leading
improved
outcomes.
Journal of Bio-X Research,
Год журнала:
2024,
Номер
7
Опубликована: Янв. 1, 2024
Artificial
intelligence
(AI)
and
machine
learning
(ML)
are
revolutionizing
the
pharmaceutical
industry,
particularly
in
drug
development
delivery.
These
technologies
enable
precision
medicine
by
analyzing
extensive
datasets
to
optimize
formulations
predict
patient
responses.
AI-driven
models
enhance
nanoparticle-based
carriers,
improving
their
stability,
bioavailability,
targeting
accuracy.
ML
also
facilitates
real-time
monitoring
adaptive
control
of
release,
ensuring
better
therapeutic
outcomes.
This
review
explores
integration
AI
delivery,
highlighting
potential
accelerate
development,
reduce
costs,
advance
personalized
medicine.
Journal of Manufacturing and Materials Processing,
Год журнала:
2025,
Номер
9(4), С. 129 - 129
Опубликована: Апрель 14, 2025
Three-dimensional
(3D)
bioprinting
using
biocompatible
polymers
has
emerged
as
a
revolutionary
technique
in
tissue
engineering
and
regenerative
medicine.
These
biopolymers
mimic
the
extracellular
matrix
(ECM)
enhance
cellular
behavior.
The
current
review
presents
recent
advancements
additive
manufacturing
processes
including
Stereolithography
(SLA),
Fused
Filament
Fabrication
(FFF),
Selective
Laser
Sintering
(SLS),
inkjet
printing.
It
also
explores
fundamentals
of
3D
printing
properties
for
bioprinting.
By
mixing
biopolymers,
enhancing
rheological
characteristics,
adding
bioactive
components,
further
have
been
made
organ
transplantation,
drug
development,
engineering.
As
research
progresses,
potential
to
fundamentally
transform
healthcare
system
is
becoming
obvious
clear.
However,
therapeutic
printed
structures
hindered
by
issues
such
material
anisotropy,
poor
mechanical
properties,
need
more
biodegradable
architectures.
Future
should
concentrate
on
optimizing
process
sophisticated
computational
techniques,
systematically
examining
characteristics
customizing
bioinks
different
cell
types,
exploring
sustainable
materials.
Deleted Journal,
Год журнала:
2024,
Номер
unknown, С. 01 - 10
Опубликована: Июль 19, 2024
The
growing
interest
in
nanoparticles
modern
research
is
due
to
their
potential
uses
different
fields
of
study.
Throughout
human
history,
individuals
have
been
exposed
environmental
nanosized
particles,
and
over
the
past
century,
these
exposures
significantly
risen.
Through
injection,
ingestion,
inhalation,
can
change
material's
physicochemical
characteristics
improve
its
ability
absorb
interact
with
biological
tissues.
Nanoparticles
penetrate
cell
membrane
reach
up
mitochondria
nucleus,
causing
gene
mutation
inhibiting
mitochondrial
process
involved
metabolism.
toxicity
associated
size,
shape,
charge,
surface
area,
chemical
composition,
other
linked
factors.
vivo
behavior
still
a
major
question
that
needs
be
resolved.
tests
are
performed
against
new
during
developmental
eliminate
or
ameliorate
identified
toxic
characteristics.
