Synthesis of cellulose nanocrystals from jute fibers for reinforcement in bio-nanocomposite films: fabrication and characterization DOI
Mir Sahidul Ali, Mir Sahanur Ali, Shubhranshu Bhandari

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 246(1)

Published: Dec. 11, 2024

Cellulose nanocrystals (CNCs) were synthesized from jute fiber by acid hydrolysis method. Our research aims to fabricate cellulose reinforced methyl (MC) and chitosan (CH) bio-nanocomposites (BNCs) loaded with ketorolac tromethamine (KT) drug. The BNC films fabricated solvent evaporation technique. We have investigated the chemical structure, morphology mechanical properties of formulations using Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Universal testing machine (UTM), dynamic light scattering (DLS), contact angle (CA) scanning electron microscopy (SEM). CNCs BNCs showed excellent material property which may a broad vista in realistic biomedical application.

Language: Английский

Essential oils as antibacterials against multidrug-resistant foodborne pathogens: Mechanisms, recent advances, and legal considerations DOI
Mabrouk Sobhy, Esraa A. Abdelkarim, Mohamed A. Hussein

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: 64, P. 105937 - 105937

Published: Jan. 18, 2025

Language: Английский

Citations

6
3D printing technology and its revolutionary role in stent implementation in cardiovascular disease DOI
Muhammad Amir Khan,

Niyamat Khan,

Muneeb Ullah

et al.

Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: 49(6), P. 102568 - 102568

Published: April 8, 2024

Language: Английский

Citations

12
Exploring Elastic Lipid Nanovesicles for Enhanced Skin Permeation of Whole Plant Extract: A Comprehensive Investigation DOI Open Access
Rahul Maheshwari, Mayank Sharma, Sankha Bhattacharya

et al.

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2025, Volume and Issue: 113(1)

Published: Jan. 1, 2025

A new method is developed using elastic lipid nanovesicles (ELNs) loaded with ethanolic extract of Lantana camara (LC) to enhance skin permeation plant actives. The ELNs contained cholesterol, 1, 2-distearoyl-sn-glycero-3-phosphocholine, span 80, and tween 80. Firstly, 15 formulations were produced examine critical factors likely affecting formulation characteristics. In addition, surface characteristics, vesicle size, polydispersity index, zeta potential, degree deformability, % entrapment efficiency (% EE) ELN examined. As a significant parameter, was measured (using Start-M; it highly resembles human skin). influence hydrophilic-lipophilic balance (HLB), ratio vital through Start-M. particular, the LC decreased at more extensive size ranges, 400, 350-450 nm. contrast, increased significantly smaller such as 200 100 More than 75% permeated within 8 h when surfactant (span 80:tween 80; 25%:75%). Permeation studies conducted based on HLB values revealed that 78% in 12.2, an increase HLB. Cell viability assay SK-MEL-37 cells (skin cancer) reduced by ~80% 24 h, further validating formulation. Future research could investigate long-term safety therapeutic potential these clinical settings their effectiveness delivering other plant-based extracts for transdermal applications via ELNs.

Language: Английский

Citations

1
Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy DOI Creative Commons
Ririn Puspadewi, Tiana Milanda, Muhaimin Muhaimin

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 209 - 209

Published: Feb. 4, 2025

This study conducted a literature review by searching for articles related to the treatment of skin infections/wrinkles using nano-delivery systems containing natural compounds. The search was in various databases published last 10 years, with strict inclusion and exclusion criteria. Of 490 found, 40 were considered relevant. Acne vulgaris is common dermatological disorder characterised inflammation sebaceous glands, often resulting development pimples, cysts, scarring. Conventional treatments, including antibiotics topical retinoids, frequently demonstrate limitations such as side effects, resistance, insufficient absorption. Recent advancements nanotechnology have enabled creation innovative drug-delivery that enhance effectiveness reduce adverse effects anti-acne medications. Polyphenols flavonoids, bioactive compounds notable anti-inflammatory, antioxidant, antibacterial properties, are recognised their therapeutic acne treatment. However, practical application hindered solubility, stability, bioavailability. incorporation these into nanoparticle-based delivery has shown promise resolving challenges. Various nanoparticle platforms, lipid-based nanoparticles, polymeric solid lipid evaluated ability improve controlled release, targeted polyphenols flavonoids skin. advent polyphenol flavonoid-loaded nanoparticles marks new therapy era.

Language: Английский

Citations

1
Key Transdermal Patch Using Cannabidiol-Loaded Nanocarriers with Better Pharmacokinetics in vivo DOI Creative Commons
Po-Cheng Chu,

Man-Hua Liao,

Mao-Gu Liu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4321 - 4337

Published: May 1, 2024

Cannabidiol (CBD) is a promising therapeutic drug with low addictive potential and favorable safety profile. However, CBD did face certain challenges, including poor solubility in water oral bioavailability. To harness the of by combining it transdermal delivery system (TDDS). This innovative approach sought to develop patch dosage form micellar vesicular nanocarriers enhance bioavailability CBD, leading improved outcomes.

Language: Английский

Citations

5
Artificial Intelligence (AI) and Machine Learning (ML) Implemented Drug Delivery Systems: A paradigm shift in the Pharmaceutical industry DOI Creative Commons
Goutam Kumar Jena, Chinam Niranjan Patra, Sruti Jammula

et al.

Journal of Bio-X Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Artificial intelligence (AI) and machine learning (ML) are revolutionizing the pharmaceutical industry, particularly in drug development delivery. These technologies enable precision medicine by analyzing extensive datasets to optimize formulations predict patient responses. AI-driven models enhance nanoparticle-based carriers, improving their stability, bioavailability, targeting accuracy. ML also facilitates real-time monitoring adaptive control of release, ensuring better therapeutic outcomes. This review explores integration AI delivery, highlighting potential accelerate development, reduce costs, advance personalized medicine.

Language: Английский

Citations

4
Nanocarriers and their Integrated Microneedle Systems-Mediated Drug Delivery for the Treatment of Moderate-Severe Dermatological Diseases: Recent Progress, Applications and Future Perspectives DOI
Mridusmita Das, Rabinarayan Parhi

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106748 - 106748

Published: Feb. 22, 2025

Language: Английский

Citations

0
Thermal Spraying of MPEA Coatings: Techniques, Properties, and Biomedical Applications DOI
Ajay Sharma, Rajeev Verma, Varun Sharma

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112482 - 112482

Published: April 1, 2025

Language: Английский

Citations

0
Recent Trends and Future Directions in 3D Printing of Biocompatible Polymers DOI Creative Commons
Maryam Aftab, S. Ikram, Muneeb Ullah

et al.

Journal of Manufacturing and Materials Processing, Journal Year: 2025, Volume and Issue: 9(4), P. 129 - 129

Published: April 14, 2025

Three-dimensional (3D) bioprinting using biocompatible polymers has emerged as a revolutionary technique in tissue engineering and regenerative medicine. These biopolymers mimic the extracellular matrix (ECM) enhance cellular behavior. The current review presents recent advancements additive manufacturing processes including Stereolithography (SLA), Fused Filament Fabrication (FFF), Selective Laser Sintering (SLS), inkjet printing. It also explores fundamentals of 3D printing properties for bioprinting. By mixing biopolymers, enhancing rheological characteristics, adding bioactive components, further have been made organ transplantation, drug development, engineering. As research progresses, potential to fundamentally transform healthcare system is becoming obvious clear. However, therapeutic printed structures hindered by issues such material anisotropy, poor mechanical properties, need more biodegradable architectures. Future should concentrate on optimizing process sophisticated computational techniques, systematically examining characteristics customizing bioinks different cell types, exploring sustainable materials.

Language: Английский

Citations

0
Cytotoxicity and genotoxicity induced by metal-based nanoparticles in humans and animals DOI Creative Commons

Lala Rukh,

Saif Ullah,

Muhammad Ameer Qarib Naqvi

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown, P. 01 - 10

Published: July 19, 2024

The growing interest in nanoparticles modern research is due to their potential uses different fields of study. Throughout human history, individuals have been exposed environmental nanosized particles, and over the past century, these exposures significantly risen. Through injection, ingestion, inhalation, can change material's physicochemical characteristics improve its ability absorb interact with biological tissues. Nanoparticles penetrate cell membrane reach up mitochondria nucleus, causing gene mutation inhibiting mitochondrial process involved metabolism. toxicity associated size, shape, charge, surface area, chemical composition, other linked factors. vivo behavior still a major question that needs be resolved. tests are performed against new during developmental eliminate or ameliorate identified toxic characteristics.

Language: Английский

Citations

3