Thermo- and pH responsive core–shell nanogels: Easy method of synthesis, properties and its use for the loading and releasing of organotin(IV) compounds

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113822 - 113822

Опубликована: Фев. 1, 2025

Язык: Английский

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Dual-responsive semi-IPN hydrogels based on poly (N-isopropyl acrylamide-co-acrylic acid)/glycyrrhizin cross-linked chitosan for controlled drug release

Journal of Polymer Research, Год журнала: 2025, Номер 32(4)

Опубликована: Апрель 1, 2025

Язык: Английский

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Intelligent responsive nanogels: New Horizons in cancer therapy

International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125050 - 125050

Опубликована: Дек. 5, 2024

Язык: Английский

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pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(16), С. 18964 - 18978

Опубликована: Авг. 2, 2024

In the realm of colon-based drug delivery, developing a pH-responsive nanocarrier that exhibits significant intrinsic reactive oxygen species (ROS) scavenging activity holds great promise. To address this, nanogel (NG) is synthesized using itaconic acid (IAc) and acrylamide (AAm) monomers in molar ratio 1:4 via free radical polymerization. The spherical NG size 190 ± 15 nm confirmed by field emission scanning electron microscopy (FESEM). Dynamic light scattering (DLS) characterization reveals hydrodynamic diameter zeta potential 271 23 −6.9 2.3 mV, respectively. FTIR, XPS, NMR analyses confirm presence multiple functionalities on NG. Significant improvement swelling (10 times) at colonic pH (pH 7.4) contrast to gastric 1.2) ensures behavior along with five times higher ROS compared control. As model drug, doxorubicin (DOX) employed investigate release properties cellular uptake. exhibited loading capacity efficiency 26 1.2% 90 1.3%, respectively, three DOX 7.4 than 1.2. Rheology data reveal superior structural integrity loaded (DNG) biocompatibility through MTT, hemolysis assay, cell uptake assays HCT-116 colon cancer cells. studies have indicated NG-mediated microenvironment subsequent passive diffusion into These findings underscore capability as vehicle for oral delivery colon.

Язык: Английский

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Comparative Study of pH-Responsive and Aggregation Stability of Bosutinib-Loaded Nanogels Comprising Gelatin Methacryloyl, Carboxymethyl Dextran, and Hyaluronic Acid for Controlled Drug Delivery in Colorectal Cancer: An Extensive In Vitro Investigation

Biomacromolecules, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These achieved high drug entrapment efficiencies (80–90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking sonication. The stable, negative zeta potentials (−20 to −30 mV) particle sizes between 100 200 nm. Fourier-transform infrared analysis confirmed successful methacrylation GelMA nanogels. Sustained BOSU release at pH 5.0 was observed, resembling tumor environments, compared slower normal (7.4). Cytotoxicity tests showed 70–80% cell survival reduction HCT116 cells higher doses, GelMA-BOSU notably reduced migration. Antiangiogenic effects a chick chorioallantoic membrane model, highlighting potential these targeted delivery therapy.

Язык: Английский

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Dual-responsive Semi-IPN Hydrogels Based on Poly (N-isopropyl Acrylamide-co-Acrylic acid)/ Glycyrrhizin Cross-linked Chitosan for Controlled Drug Release

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

The development of novel semi-IPN hydrogels composed a cross-linked chitosan (CC) network and thermo-responsive linear copolymer, i.e. poly(N-isopropyl acrylamide-co-acrylic acid) [P(NIPAM-co-AA)], with drug release capability in response to both temperature pH changes has various potential medical applications. free copolymer chains inside the CC were synthesized via free-radical polymerization prepare thermal dual-responsive P(NIPAM-co-AA)/CC structure. prepared copolymers characterized by FTIR, TGA, ¹H ¹³C NMR apparatus, LCST transition was determined using UV/Vis spectroscopy. stronger C-H stretching sample at 2920 cm^{− 1} than showed that NIPAM AA monomers successfully polymerized TGA analysis exhibited peaks 249, 379, 290°C, corresponding presence composition polymer, respectively. results depending on below above LCST, hydrogel lower (194%) higher swelling percentage (413%) because chain conformation changed form coil globule. implied hydrogen bond between gallic acid molecules (GA, model) structure may be broken, causing change range 4.5 − 39.1%. anti-bacterial test cytotoxicity selected carried out. In an MTT assay, highest cell viability 7.5 mg/ml 37°C 4% more control group. containing GA action against S aureus bacterial strain significantly. This research describes method smart for transdermal

Язык: Английский

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Inhalable multi-stimulus sensitive curcumin-alginate nanogels for scavenging reactive oxygen species and anti-inflammatory co-ordination to alleviate acute lung injury

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 137816 - 137816

Опубликована: Ноя. 1, 2024

Язык: Английский

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