Molecular nature of ocular surface barrier function, diseases that affect it, and its relevance for ocular drug delivery

The Ocular Surface, Год журнала: 2023, Номер 30, С. 3 - 13

Опубликована: Авг. 3, 2023

Язык: Английский

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Ectoine protects corneal epithelial survival and barrier from hyperosmotic stress by promoting anti-inflammatory cytokine IL-37

The Ocular Surface, Год журнала: 2024, Номер 32, С. 182 - 191

Опубликована: Март 13, 2024

Язык: Английский

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Ectopic lymphoid structures in the aged lacrimal glands

Clinical Immunology, Год журнала: 2023, Номер 248, С. 109251 - 109251

Опубликована: Фев. 3, 2023

Aging is a complex biological process in which many organs are pathologically affected. We previously reported that aged C57BL/6J had increased lacrimal gland (LG) lymphoid infiltrates suggest ectopic structures. However, these structures have not been fully investigated. Using mice of different ages, we analyzed the transcriptome murine LGs and characterized B T cell populations. Age-related changes LG include differentially expressed genes associated with activation, germinal center formation, infiltration by marginal zone-like cells. also identified an age-related increase B1

Язык: Английский

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TNF is a critical cytokine in age-related dry eye disease

The Ocular Surface, Год журнала: 2023, Номер 30, С. 119 - 128

Опубликована: Авг. 26, 2023

Язык: Английский

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Destructive and Protective Effects and Therapeutic Targets of IL-36 Family Cytokines in Dry Eye Disease

The Ocular Surface, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Cathepsin S: A key drug target and signalling hub in immune system diseases

International Immunopharmacology, Год журнала: 2025, Номер 155, С. 114622 - 114622

Опубликована: Апрель 14, 2025

Язык: Английский

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Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Сен. 16, 2024

Язык: Английский

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Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 25, 2024

The female reproductive system is one of the first to age in humans, resulting infertility and endocrine disruptions. aging ovary assumes a fibro-inflammatory milieu which negatively impacts gamete quantity quality as well ovulation. Here we tested whether systemic delivery anti-inflammatory (Etanercept) or anti-fibrotic (Pirfenidone) drugs attenuates ovarian mice. We evaluated ability these decrease expression genes primary stromal cells. Whereas Etanercept did not block

Язык: Английский

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Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function

Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)

Опубликована: Май 9, 2024

Abstract Background Cathepsin S (CTSS) is a cysteine protease that played diverse roles in immunity, tumor metastasis, aging and other pathological alterations. At the cellular level, increased CTSS levels have been associated with secretion of pro-inflammatory cytokines disrupted homeostasis Ca 2+ flux. Once was suppressed, elevated anti-inflammatory changes influx were observed. These findings inspired us to explore potential role on cognitive functions. Methods We conducted classic Y-maze Barnes Maze tests assess spatial working memory Ctss −/− mice, + / mice injected inhibitor (RJW-58). Ex vivo analyses including long-term potentiation (LTP), Golgi staining, immunofluorescence staining sectioned whole brain tissues obtained from experimental animals conducted. Furthermore, molecular studies carried out using cultured HT-22 cell line primary cortical neurons treated RJW-58 comprehensively gene protein expressions. Results Our reported targeting cathepsin yields improvements function, enhancing both behavior models. showed synaptic complexity. Microarray analysis demonstrated brain-derived neurotrophic factor (BDNF) upregulated when knocked down by siRNA. Moreover, pharmacological blockade enzymatic activity promoted BDNF expression dose- time-dependent manner. Notably, inhibition neurogenesis murine dentate gyrus. results suggested promising modulation enhancement neurogenesis. Conclusion suggest critical regulation function modulating influx, leading enhanced activation BDNF/TrkB axis. study may provide novel strategy for improving CTSS.

Язык: Английский

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Age-Related Differences in the Mouse Corneal Epithelial Transcriptome and Their Impact on Corneal Wound Healing

Investigative Ophthalmology & Visual Science, Год журнала: 2024, Номер 65(5), С. 21 - 21

Опубликована: Май 13, 2024

Aging is a risk factor for dry eye. We sought to identify changes in the aged mouse corneal epithelial transcriptome and determine how age affects sensitivity, re-epithelialization, barrier reformation after debridement.

Язык: Английский

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