EDITORIAL: Special issue on the Tear Film and the Ocular Surface DOI
Tatiana Maria Suarez-Cortes, Mary Ann Stepp

Experimental Eye Research, Journal Year: 2023, Volume and Issue: 238, P. 109705 - 109705

Published: Nov. 7, 2023

Language: Английский

Molecular nature of ocular surface barrier function, diseases that affect it, and its relevance for ocular drug delivery DOI Creative Commons
K. Paul Satinder,

Peri Sohnen,

Sudha Swamynathan

et al.

The Ocular Surface, Journal Year: 2023, Volume and Issue: 30, P. 3 - 13

Published: Aug. 3, 2023

Language: Английский

Citations

18
Ectoine protects corneal epithelial survival and barrier from hyperosmotic stress by promoting anti-inflammatory cytokine IL-37 DOI
Jinmiao Li,

Na Lin,

Yun Zhang

et al.

The Ocular Surface, Journal Year: 2024, Volume and Issue: 32, P. 182 - 191

Published: March 13, 2024

Language: Английский

Citations

7
Ectopic lymphoid structures in the aged lacrimal glands DOI Creative Commons
Jeremías G. Galletti, Kaitlin K. Scholand, Claudia M. Trujillo‐Vargas

et al.

Clinical Immunology, Journal Year: 2023, Volume and Issue: 248, P. 109251 - 109251

Published: Feb. 3, 2023

Aging is a complex biological process in which many organs are pathologically affected. We previously reported that aged C57BL/6J had increased lacrimal gland (LG) lymphoid infiltrates suggest ectopic structures. However, these structures have not been fully investigated. Using mice of different ages, we analyzed the transcriptome murine LGs and characterized B T cell populations. Age-related changes LG include differentially expressed genes associated with activation, germinal center formation, infiltration by marginal zone-like cells. also identified an age-related increase B1

Language: Английский

Citations

13
TNF is a critical cytokine in age-related dry eye disease DOI Creative Commons
Yashaswini Kelagere, Kaitlin K. Scholand, Erica N. DeJong

et al.

The Ocular Surface, Journal Year: 2023, Volume and Issue: 30, P. 119 - 128

Published: Aug. 26, 2023

Language: Английский

Citations

13
Destructive and Protective Effects and Therapeutic Targets of IL-36 Family Cytokines in Dry Eye Disease DOI
Xin Chen, Na Lin, Haixia Liu

et al.

The Ocular Surface, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cathepsin S: A key drug target and signalling hub in immune system diseases DOI

D. Evangelin Geetha,

Tom Skaria

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114622 - 114622

Published: April 14, 2025

Language: Английский

Citations

0
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse DOI
Farners Amargant,

Carol Magalhaes,

Michele T. Pritchard

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Language: Английский

Citations

3
Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse DOI Creative Commons
Farners Amargant,

Carol Vieira,

Michele T. Pritchard

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

The female reproductive system is one of the first to age in humans, resulting infertility and endocrine disruptions. aging ovary assumes a fibro-inflammatory milieu which negatively impacts gamete quantity quality as well ovulation. Here we tested whether systemic delivery anti-inflammatory (Etanercept) or anti-fibrotic (Pirfenidone) drugs attenuates ovarian mice. We evaluated ability these decrease expression genes primary stromal cells. Whereas Etanercept did not block

Language: Английский

Citations

2
Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function DOI Creative Commons
Hao-Wei Lee,

Szu-Jung Chen,

Kuen‐Jer Tsai

et al.

Journal of Biomedical Science, Journal Year: 2024, Volume and Issue: 31(1)

Published: May 9, 2024

Abstract Background Cathepsin S (CTSS) is a cysteine protease that played diverse roles in immunity, tumor metastasis, aging and other pathological alterations. At the cellular level, increased CTSS levels have been associated with secretion of pro-inflammatory cytokines disrupted homeostasis Ca 2+ flux. Once was suppressed, elevated anti-inflammatory changes influx were observed. These findings inspired us to explore potential role on cognitive functions. Methods We conducted classic Y-maze Barnes Maze tests assess spatial working memory Ctss −/− mice, + / mice injected inhibitor (RJW-58). Ex vivo analyses including long-term potentiation (LTP), Golgi staining, immunofluorescence staining sectioned whole brain tissues obtained from experimental animals conducted. Furthermore, molecular studies carried out using cultured HT-22 cell line primary cortical neurons treated RJW-58 comprehensively gene protein expressions. Results Our reported targeting cathepsin yields improvements function, enhancing both behavior models. showed synaptic complexity. Microarray analysis demonstrated brain-derived neurotrophic factor (BDNF) upregulated when knocked down by siRNA. Moreover, pharmacological blockade enzymatic activity promoted BDNF expression dose- time-dependent manner. Notably, inhibition neurogenesis murine dentate gyrus. results suggested promising modulation enhancement neurogenesis. Conclusion suggest critical regulation function modulating influx, leading enhanced activation BDNF/TrkB axis. study may provide novel strategy for improving CTSS.

Language: Английский

Citations

2
Age-Related Differences in the Mouse Corneal Epithelial Transcriptome and Their Impact on Corneal Wound Healing DOI Creative Commons
Anmar Abu-Romman, Kaitlin K. Scholand, Gowthaman Govindarajan

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(5), P. 21 - 21

Published: May 13, 2024

Aging is a risk factor for dry eye. We sought to identify changes in the aged mouse corneal epithelial transcriptome and determine how age affects sensitivity, re-epithelialization, barrier reformation after debridement.

Language: Английский

Citations

2