International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(21), С. 13528 - 13528
Опубликована: Ноя. 4, 2022
The
invasion
of
microbial
pathogens
and/or
sterile
inflammation
caused
by
physical/chemical
injuries,
increased
ocular
pressure,
oxidative
stress,
and
ischemia
could
lead
to
the
generation
detrimental
immune
responses
in
eyes,
which
result
excessive
tissue
injury
vision
loss.
bioavailability
eye
drops
that
are
enriched
with
immunoregulatory
trophic
factors
may
concurrently
suppress
intraocular
promote
repair
regeneration
is
generally
low.
We
recently
developed
"derived-
Multiple
Allogeneic
Proteins
Paracrine
Signaling
regenerative
biologics
platform
technology
d-MAPPS™",
a
bioengineered
biological
product
immunomodulatory
can
efficiently
injured
corneal
retinal
tissues.
results
obtained
preclinical
clinical
studies
showed
d-MAPPS™
viability
cells,
inhibited
production
inflammatory
cytokines
alleviated
inflammation,
restored
loss
patients
suffering
from
meibomian
gland
dysfunction
dry
disease.
Herewith,
we
emphasized
molecular
mechanisms
responsible
for
therapeutic
efficacy
presented
main
beneficial
effects
settings,
indicating
topical
administration
be
considered
new
approach
treatment
diseases
Translational Vision Science & Technology,
Год журнала:
2024,
Номер
13(12), С. 11 - 11
Опубликована: Дек. 10, 2024
The
corneal
nerves
within
the
sub-basal
nerve
plexus
(SBNP)
display
a
distinctive
whorl-like
pattern,
highly
dynamic
structure
that
could
be
marker
of
diseases.
Previous
studies
have
reported
decrease
in
whorl
density
patients
with
diabetes,
indicating
an
avenue
for
noninvasive
monitoring
diabetic
neuropathy.
However,
conflicting
results
since
been
reported,
highlighting
need
improved
quantitative
analysis
whorl.
We
present
automated
algorithm
to
characterize
shape
and
test
hypothesis
organization
is
affected
by
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 5, 2023
Introduction
Diabetic
ocular
complications
include
sight-threatening
consequences
and
decreased
corneal
sensitivity,
characterized
by
tear
production,
sensitivity
delayed
epithelial
wound
healing.
The
pathogenesis
of
diabetic
disorders
remains
largely
unknown.
Growing
evidence
implies
the
participation
immune
cells
in
development
diseases.
Nonetheless,
immunological
changes
that
result
problems
are
Methods
Mass
cytometry
time
flight
(CyTOF)
was
used
to
investigate
cell
cluster
alterations
associated
with
disorders.
CyTOF
test
performed
on
at
a
single
level
from
21-week-old
(db/db)
non-diabetic
(db/m)
mice.
A
panel
41
immune-related
markers
monitored
different
types
corneas.
To
proportion
each
subpopulation,
an
unsupervised
clustering
method
employed,
T-distributed
stochastic
neighbor
embedding
visualize
distinctions
between
subsets.
Results
Through
test,
we
identified
10
subsets
tissues.
In
novel
way,
discovered
significant
corneas,
including
pronounced
T
myeloid
subgroups
corneas
linked
potential
biomarkers,
CD103,
CCR2,
SiglecF,
Ly6G,
CD172a.
Comprehensive
profiling
indicated
remarkable
microenvironment
notable
decrease
CD103+CD8+
tissue-resident
memory
(T
RM
)
Tregs,
as
well
dramatic
increase
γδT
CD11b+Ly6G+
myeloid-derived
suppressor
(MDSCs).
Conclusion
analysis
revealed
during
complications.
This
study
mapped
landscape
type
2
providing
fundamental
understanding
immune-driven
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(21), С. 13528 - 13528
Опубликована: Ноя. 4, 2022
The
invasion
of
microbial
pathogens
and/or
sterile
inflammation
caused
by
physical/chemical
injuries,
increased
ocular
pressure,
oxidative
stress,
and
ischemia
could
lead
to
the
generation
detrimental
immune
responses
in
eyes,
which
result
excessive
tissue
injury
vision
loss.
bioavailability
eye
drops
that
are
enriched
with
immunoregulatory
trophic
factors
may
concurrently
suppress
intraocular
promote
repair
regeneration
is
generally
low.
We
recently
developed
"derived-
Multiple
Allogeneic
Proteins
Paracrine
Signaling
regenerative
biologics
platform
technology
d-MAPPS™",
a
bioengineered
biological
product
immunomodulatory
can
efficiently
injured
corneal
retinal
tissues.
results
obtained
preclinical
clinical
studies
showed
d-MAPPS™
viability
cells,
inhibited
production
inflammatory
cytokines
alleviated
inflammation,
restored
loss
patients
suffering
from
meibomian
gland
dysfunction
dry
disease.
Herewith,
we
emphasized
molecular
mechanisms
responsible
for
therapeutic
efficacy
presented
main
beneficial
effects
settings,
indicating
topical
administration
be
considered
new
approach
treatment
diseases
