Molecular Biology Reports, Год журнала: 2024, Номер 51(1)
Опубликована: Апрель 4, 2024
Язык: Английский
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Апрель 25, 2023
In the working-age population worldwide, diabetic retinopathy (DR), a prevalent complication of diabetes, is main cause vision impairment. Chronic low-grade inflammation plays an essential role in DR development. Recently, concerning pathogenesis DR, Nod-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome retinal cells has been determined as causal factor. eye, NLRP3 activated by several pathways (such ROS and ATP). The activation NPRP3 leads to secretion inflammatory cytokines interleukin-1β (IL-1β) interleukin-18 (IL-18), pyroptosis, rapid form lytic programmed cell death (PCD). Cells that undergo pyroptosis swell rapture, releasing more factors accelerating progression. This review focuses on mechanisms activate leading DR. present research highlighted some inhibitors NLRP3/pyroptosis novel therapeutic measures treatment.
Язык: Английский
Процитировано
63
EMBO Molecular Medicine, Год журнала: 2024, Номер 16(2), С. 294 - 318
Опубликована: Янв. 31, 2024
Abstract Diabetic retinopathy (DR) is a leading cause of irreversible vision loss in working-age populations. Fat mass and obesity-associated protein (FTO) an N 6 -methyladenosine (m A) demethylase that demethylates RNAs involved energy homeostasis, though its influence on DR not well studied. Herein, we detected elevated FTO expression vitreous fibrovascular membranes patients with proliferative DR. promoted cell cycle progression tip formation endothelial cells (ECs) to facilitate angiogenesis vitro, mice, zebrafish. also regulated EC-pericyte crosstalk trigger diabetic microvascular leakage, mediated EC–microglia interactions induce retinal inflammation neurodegeneration vivo vitro. Mechanistically, affected EC features via modulating CDK2 mRNA stability m A-YTHDF2-dependent manner. up-regulation under conditions was driven by lactate-mediated histone lactylation. FB23-2, inhibitor FTO’s A activity, suppressed angiogenic phenotypes To allow for systemic administration, developed nanoplatform encapsulating FB23-2 confirmed targeting therapeutic efficiency mice. Collectively, our study demonstrates important function homeostasis DR, warrants further investigation as target patients.
Язык: Английский
Процитировано
37
Antioxidants, Год журнала: 2023, Номер 12(2), С. 510 - 510
Опубликована: Фев. 17, 2023
Oxidative stress (OS) refers to a state of imbalance between oxidation and antioxidation. OS is considered be an important factor leading aging range diseases. The eyes are highly oxygen-consuming organs. Due its continuous exposure ultraviolet light, the eye particularly vulnerable impact OS, diseases such as corneal disease, cataracts, glaucoma, etc. N6-methyladenosine (m6A) modification most investigated RNA post-transcriptional participates in variety cellular biological processes. In this study, we review role m6A oxidative stress-induced some therapeutic methods provide relatively overall understanding stress-related
Язык: Английский
Процитировано
17
Journal of Diabetes, Год журнала: 2023, Номер 15(5), С. 382 - 396
Опубликована: Март 2, 2023
Abstract Diabetic retinopathy (DR) is one of the most prevalent retinal disorders worldwide, and it a major cause vision impairment in individuals productive age. Research has demonstrated significance autophagy DR, which critical intracellular homeostasis mechanism required for destruction recovery cytoplasmic components. Autophagy maintains physiological function senescent impaired organelles under stress situations, thereby regulating cell fate via various signals. As retina's functional fundamental unit, neurovascular unit (NVU) keeping environment's stability supporting needs metabolism. However, essential normal NVU structure function. We discuss strong association between DR this review, as well many kinds its crucial activities retina. By evaluating pathological changes latest advancements molecular mechanisms that may be involved pathophysiology NVU, we seek to propose new ideas methods prevention treatment DR.
Язык: Английский
Процитировано
17
Experimental Eye Research, Год журнала: 2023, Номер 231, С. 109489 - 109489
Опубликована: Апрель 20, 2023
Язык: Английский
Процитировано
17
International Journal of Biological Sciences, Год журнала: 2023, Номер 19(6), С. 1748 - 1763
Опубликована: Янв. 1, 2023
N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA modification in eukaryotes, has recently become a hot research topic.Several studies have indicated that m6A is dysregulated during progression of multiple diseases, especially cancer development.Programmed cell death (PCD) an active orderly method development organisms, including apoptosis, autophagy, pyroptosis, ferroptosis, necroptosis.As study PCD increasingly profound, accumulating evidence revealed mutual regulation PCD, their interaction can further influence sensitivity treatment.In this review, we summarize recent advances terms interplay potential mechanisms, as well therapeutic resistance.Our provides promising insights future directions for examination treatment cancers.
Язык: Английский
Процитировано
16
Pharmacological Research, Год журнала: 2023, Номер 197, С. 106946 - 106946
Опубликована: Окт. 4, 2023
Ocular neovascular disease (OND), characterized by the aberrant formation of immature blood vessels, is leading cause vision impairment and blindness. It important to find effective ways diagnose treat these diseases. Circular RNA (circRNA) a group endogenous non-coding that play crucial role in regulating different biological processes. Due their close association with ocular angiogenesis, circRNAs have become hotspot OND research. In this review, we intensively investigate possibility using management ONDs. general, angiogenesis divided into five phases. On basis steps, describe potential introducing how they regulate angiogenesis. Subsequently, interactions between ONDs, including pterygium, corneal neovascularization, age-related macular degeneration, diabetic retinopathy, retinopathy prematurity, are analyzed detail. We also introduce use as diagnostic biomarkers. Finally, summarize prospects strategy management. The gaps recent research pointed out purpose promoting introduction clinical applications.
Язык: Английский
Процитировано
16
Molecular Medicine Reports, Год журнала: 2023, Номер 28(4)
Опубликована: Авг. 17, 2023
Diabetic retinopathy (DR) is a microvascular complication of diabetes. The retinal pigment epithelium (RPE) forms the outer layer blood‑retinal barrier and serves role in maintaining function. RPE cell injury has been revealed diabetic animal models, high glucose (HG) levels may cause damage to cells by increasing oxidative stress, promoting pro‑inflammatory gene expression, disrupting proliferation, inducing endothelial‑mesenchymal transition, weakening tight conjunctions elevating death mechanisms, such as apoptosis, ferroptosis pyroptosis. Non‑coding RNAs including microRNAs, long non‑coding circular participate caused HG levels, which provide targeted therapeutic strategies for treatment DR. Plant extracts citrusin hesperidin, number hypoglycemic drugs, sodium‑glucose co‑transporter 2 inhibitors, metformin glucagon‑like peptide‑1 receptor agonists, exhibit potential protective effects; however, detailed mechanisms behind these effects remain be fully elucidated. An in‑depth understanding contribution DR novel perspectives targets
Язык: Английский
Процитировано
12
Journal of Molecular Medicine, Год журнала: 2024, Номер 102(4), С. 495 - 505
Опубликована: Фев. 23, 2024
Язык: Английский
Процитировано
5
Journal of Cancer Research and Clinical Oncology, Год журнала: 2022, Номер 149(7), С. 3977 - 3988
Опубликована: Авг. 28, 2022
Язык: Английский
Процитировано
19