European journal of medical research,
Год журнала:
2023,
Номер
28(1)
Опубликована: Ноя. 24, 2023
Abstract
This
paper
gives
a
detailed
analysis
of
nanotechnology's
rising
involvement
in
numerous
surgical
fields.
We
investigate
the
use
nanotechnology
orthopedic
surgery,
neurosurgery,
plastic
oncology,
heart
vascular
ophthalmic
thoracic
and
minimally
invasive
surgery.
The
details
how
helps
with
arthroplasty,
chondrogenesis,
tissue
regeneration,
wound
healing,
more.
It
also
discusses
employment
nanomaterials
implant
surfaces,
bone
grafting,
breast
implants,
among
other
things.
article
explores
various
uses,
including
stem
cell-incorporated
nano
scaffolds,
nano-surgery,
hemostasis,
nerve
nanorobots,
diagnostic
applications.
ethical
safety
implications
using
surgery
are
addressed.
future
possibilities
investigated,
pointing
to
possible
route
for
improved
patient
outcomes.
essay
finishes
comment
on
transformational
influence
applications
its
promise
breakthroughs.
Graphical
Indian Journal of Ophthalmology,
Год журнала:
2023,
Номер
71(4), С. 1292 - 1303
Опубликована: Апрель 1, 2023
Definitive
treatment
of
dry
eye
disease
(DED),
one
the
commonest
ocular
surface
disorders,
has
remained
elusive
despite
several
recent
advances
in
better
diagnostics
and
introduction
newer
therapeutic
molecules.
The
current
paradigms
rely
heavily
on
lubricating
drops
anti-inflammatory
agents
that
may
need
to
be
used
long-term
are
mainly
palliative.
Research
is
ongoing
not
only
for
a
curative
option
but
also
improve
potency
efficacy
existing
drug
molecules
through
formulations
delivery
platforms.
In
past
two
decades,
significant
advancement
been
made
terms
preservative-free
formulations,
biomaterials
such
as
nanosystems
hydrogels,
stem
cell
therapy,
creation
bioengineered
lacrimal
gland.
This
review
comprehensively
summarizes
approaches
DED
treatment,
which
nanosystems,
contact
lenses
delivery,
tissue-based
regenerative
therapy
damaged
gland
surface,
tissue
engineering
developing
artificial
Also,
their
potential
efficacies
animal
models
or
vitro
studies
possible
limitations
discussed.
research
looks
promising
needs
supported
with
clinical
safety
human
use.
Pharmaceutics,
Год журнала:
2023,
Номер
15(6), С. 1746 - 1746
Опубликована: Июнь 15, 2023
Chronic
ocular
diseases
can
seriously
impact
the
eyes
and
could
potentially
result
in
blindness
or
serious
vision
loss.
According
to
most
recent
data
from
WHO,
there
are
more
than
2
billion
visually
impaired
people
world.
Therefore,
it
is
pivotal
develop
sophisticated,
long-acting
drug
delivery
systems/devices
treat
chronic
eye
conditions.
This
review
covers
several
nanocarriers
that
control
disorders
non-invasively.
However,
of
developed
still
preclinical
clinical
stages.
Long-acting
systems,
such
as
inserts
implants,
constitute
majority
clinically
used
methods
for
treatment
due
their
steady
state
release,
persistent
therapeutic
activity,
ability
bypass
barriers.
implants
considered
invasive
technologies,
especially
those
nonbiodegradable.
Furthermore,
vitro
characterization
approaches,
although
useful,
limited
mimicking
truly
representing
vivo
environment.
focuses
on
systems
(LADDS),
particularly
implantable
(IDDS),
formulation,
characterization,
application
diseases.
Nanomaterials,
Год журнала:
2024,
Номер
14(8), С. 669 - 669
Опубликована: Апрель 12, 2024
Dry
eye
disease
(DED)
incidence
is
continuously
growing,
positioning
it
to
become
an
emergent
health
issue
over
the
next
few
years.
Several
topical
treatments
are
commonly
used
treat
DED;
however,
reports
indicate
that
only
a
minor
proportion
of
drug
bioavailability
achieved
by
majority
drops
available
on
market.
In
this
context,
enhancing
ability
overcome
ocular
barriers
and
prolonging
its
residence
time
surface
represent
new
challenge
in
field
carrier
systems.
Therefore,
research
has
focused
development
multi-functional
nanosystems,
such
as
nanoemulsions,
liposomes,
dendrimers,
hydrogels,
other
nanosized
carriers.
These
systems
designed
improve
efficacy
and,
at
same
time,
require
fewer
daily
administrations,
with
potentially
reduced
side
effects.
This
review
summarizes
different
nanotechnologies
developed,
their
role
DED,
nanotechnology-based
eyedrops
currently
approved
for
DED
treatment.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(3), С. 445 - 445
Опубликована: Март 16, 2023
Eyes
are
one
of
the
main
critical
organs
body
that
provide
our
brain
with
most
information
about
surrounding
environment.
Disturbance
in
activity
this
informational
organ,
resulting
from
different
ocular
diseases,
could
affect
quality
life,
so
finding
appropriate
methods
for
treating
disease
has
attracted
lots
attention.
This
is
especially
due
to
ineffectiveness
conventional
therapeutic
method
deliver
drugs
into
interior
parts
eye,
and
also
presence
barriers
such
as
tear
film,
blood-ocular,
blood-retina
barriers.
Recently,
some
novel
techniques,
types
contact
lenses,
micro
nanoneedles
situ
gels,
have
been
introduced
which
can
overcome
previously
mentioned
These
techniques
enhance
bioavailability
components
inside
eyes,
them
posterior
side
release
a
controlled
manner,
reduce
effects
previous
(such
eye
drops).
Accordingly,
review
paper
aims
summarize
evidence
on
effectiveness
these
new
disease,
their
preclinical
clinical
progression,
current
limitations,
future
perspectives.
Theranostics,
Год журнала:
2024,
Номер
15(3), С. 915 - 942
Опубликована: Дек. 2, 2024
Adhesive
hydrogels,
composed
of
hydrophilic
polymers
arranged
in
a
three-dimensional
network,
have
emerged
as
pivotal
innovation
ophthalmology
due
to
their
ability
securely
adhere
ocular
tissues
while
providing
sustained
therapeutic
effects.
The
eye,
with
its
delicate
structure
and
specific
needs,
presents
unique
challenges
for
drug
delivery
tissue
regeneration.
This
review
explores
the
transformative
potential
adhesive
hydrogels
addressing
these
across
range
conditions,
including
corneal
injuries,
cataracts,
glaucoma,
vitreoretinal
disorders,
trauma.
By
detailing
mechanisms
polymerization
adhesion,
this
paper
highlights
how
materials
can
be
customized
ophthalmic
applications,
offering
insights
into
current
use
future
possibilities.
emphasis
is
placed
on
clinical
significance
directions
advancing
therapy,
potentially
revolutionizing
treatment
complex
eye
diseases.
