Toxicology, Год журнала: 2023, Номер 492, С. 153553 - 153553
Опубликована: Май 22, 2023
Язык: Английский
Biogerontology, Год журнала: 2019, Номер 20(6), С. 763 - 782
Опубликована: Сен. 20, 2019
Язык: Английский
Процитировано
358
Advances in Nutrition, Год журнала: 2021, Номер 12(4), С. 1211 - 1238
Опубликована: Янв. 19, 2021
Язык: Английский
Процитировано
114
Oxidative Medicine and Cellular Longevity, Год журнала: 2018, Номер 2018(1)
Опубликована: Янв. 1, 2018
The present study was designed to evaluate the effects of matrine (MAT) on D‐galactose‐ (D‐gal‐) induced aging and relative mechanism. Vitamin E at dose 100 mg/kg used as a standard positive control. MAT significantly improved D‐gal‐induced recognition spatial memory impairment in novel object Y maze tests, exercise endurance decreased weight‐loaded swimming test 2 10 mg/kg. We found that D‐gal treatment noticeably aging‐related changes such reducing thymus coefficients, increasing pathological injury cellular senescence liver, spleen, hippocampus, well an increase cyclin‐dependent kinase inhibitor p16 , p19 p21 gene expression interleukin -1β liver hippocampus. showed effective protection changes. Furthermore, oxidative stress plasma, brain, evidenced by increased total antioxidant capacity, superoxide dismutase, catalase activities malondialdehyde level. Additionally, there significant correlation between time index. ameliorated disorder caused through inhibition both stress. provides further evidence for drug development prevention or aging‐associated disorder.
Язык: Английский
Процитировано
105
Journal of Agricultural and Food Chemistry, Год журнала: 2019, Номер 67(11), С. 3140 - 3149
Опубликована: Фев. 28, 2019
Lycium ruthenicum Murr. (LR) is a perennial shrub commonly used as nutritional food and medicine. Herein, we identified 12 anthocyanins from LR, with petunidin derivatives constituting approximately 97% of the total anthocyanin content. Furthermore, potential mechanism exerting neuroprotective effects in d-galactose (d-gal)-treated rats was explored. Behavioral results showed that relieved d-gal-induced memory disorder. Additionally, reduced receptor for advanced glycation end products (RAGE) suppressed oxidative stress caused by d-gal. Anthocyanins microgliosis astrocytosis overexpression nuclear factor kappa B (NF-κB), interleukin-1-β (IL-1β), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α). Moreover, lowered C-jun N-terminal kinase (p-JNK), caspase-3 levels, B-cell lymphoma 2-associated X protein/B-cell 2 (Bax/Bcl-2) ratio. Thus, LR attenuated disfunction, neuroinflammation, neurodegeneration d-gal, possibly through RAGE/NF-κB/JNK pathway, representing promising, safe candidate prevention therapy neurodegenerative diseases.
Язык: Английский
Процитировано
95
Oxidative Medicine and Cellular Longevity, Год журнала: 2020, Номер 2020, С. 1 - 15
Опубликована: Июнь 17, 2020
Skin aging has been associated with a higher dietary intake of carbohydrates, particularly glucose and galactose. In fact, the carbohydrates are capable damaging skin's vital components through nonenzymatic glycation, covalent attachment sugar to protein, subsequent production advanced glycation end products (AGEs). This review is focused on role D-galactose in development skin its relation oxidative stress. The interest this problem was dictated by recent findings that used vitro vivo models. highlights advances underlying molecular mechanisms D-galactose-mediated cell senescence cytotoxicity. We have also proposed possible impact galactosemia clinical relevance. understanding mediated can help dermatologists optimize methods for prevention treatment aging-related diseases.
Язык: Английский
Процитировано
80
Molecules, Год журнала: 2021, Номер 26(16), С. 4794 - 4794
Опубликована: Авг. 7, 2021
The nutrients and their potential benefits are a new field of study in modern medicine for positive impact on health. Curcumin, the yellow polyphenolic compound extracted from Curcuma longa species, is widely used traditional Ayurvedic to prevent contrast many diseases, considering its antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephron-protective, hepato-protective, anti-neoplastic, anti-rheumatic proprieties. In recent years, investigations curcumin have been focused application aging age-associated diseases. Aging physiological process which there decreasing cellular function due internal or external stimuli. Oxidative stress one most important causes age-related Moreover, disorders such as cancer, neuroinflammation, infections low-grade chronic systemic inflammation. Curcumin acting different proteins able both oxidative than brain, modulate inflammation induced by microglia. Finally brain tumors reduce tumor growth inhibition telomerase activity. This review emphasizes anti-aging role focusing mechanism counteract brain. formulations increase bioavailability discussed.
Язык: Английский
Процитировано
73
Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 137, С. 111374 - 111374
Опубликована: Фев. 18, 2021
Astaxanthin (ATX) is a red pigment carotenoid present in shrimp, salmon, crab, and asteroidean. Several studies have corroborated the anti-oxidant efficacy of ATX. In addition, ATX has anti-inflammatory, anti-apoptotic anti-proliferative properties. review, we discuss role Nrf2 mediating anti-cancer, anti-aging, neuroprotective, lung-protective, skin-protective, cardioprotective, hepatoprotective, anti-diabetic muscloprotective effects
Язык: Английский
Процитировано
68
Phytotherapy Research, Год журнала: 2021, Номер 35(8), С. 4411 - 4424
Опубликована: Май 24, 2021
Successive evidence has established that maltol, a flavor‐enhancing agent, could provide resistance to oxidative stress‐induced tissue injury in various animal models though its benefits for aging‐induced liver and kidney injuries are still undetermined. In the present work, demonstrating maltol's ameliorative effect probable mechanism against injuries, D‐galactose (D‐Gal)‐induced vivo HEK293 cells vitro were results demonstrated long‐term D‐Gal treatment increases accumulation of advanced glycation end products (AGEs) tissues, mitigates cell viability, arrests cycle. Interestingly, 4‐weeks maltol at 50 100 mg/kg activated aging‐associated proteins including p53, p21, p16 followed by inhibiting malondialdehyde (MDA)'s over‐production increasing levels antioxidant enzymes. Therefore, decreases cytochrome P450 E1 (CYP2E1) 4‐hydroxydecene (4‐HNE)'s immunofluorescence expression confirmed. Furthermore, improved stress activating phosphatidylinositol‐3‐kinase (PI3K)/protein kinase B (Akt) signaling pathway. conclusion, purpose study was estimate mechanistic insights into role as an senescence injury, which will reflect potential therapeutic strategy antiaging aging‐related disease treatment.
Язык: Английский
Процитировано
57
Cells, Год журнала: 2022, Номер 11(9), С. 1418 - 1418
Опубликована: Апрель 22, 2022
With the global increase of elderly population, improvement treatment for various aging-related diseases and extension a healthy lifespan have become some most important current medical issues. In order to understand developmental mechanisms aging disorders, animal models are essential conduct relevant studies. Among them, mice one prevalently used model animals studies due their high similarity humans in terms genetic background physiological structure, as well short ease reproduction. This review will discuss common emerging mouse accelerated related chronic recent years, with aim serving reference future application fundamental translational research.
Язык: Английский
Процитировано
42
Nutrients, Год журнала: 2025, Номер 17(2), С. 325 - 325
Опубликована: Янв. 17, 2025
Background/Objectives: A fucoidan oligosaccharide (FOS), a potent compound derived from algae, is known for its diverse biological activities, including prebiotic activity, anticancer and antioxidative properties, has demonstrated supportive therapeutic effects in treating kidney ailments. This study was conducted to explore the protective influence of FOS on damage due aging induced by D-galactose Sprague Dawley (SD) rats. Methods: The low-dose group administered (100 mg/kg) gavage, high-FOS received (200 gavage. Results: findings showed that could effectively mitigate improve pathological condition tissues caused D-gal enhance function. Intervention with significantly reduced serum creatinine, uric acid, urea nitrogen levels, compared model group. mechanism D-gal-induced injury may be inhibit oxidative stress impaired mitochondrial function downregulating AMPK/ULK1 signaling pathway. also modulate expression autophagy-related proteins (Beclin-1, P62, LC3II/LC3I), thereby excessive mitophagy kidney. Furthermore, protect against preserving intestinal homeostasis. decreased lipopolysaccharide levels enhanced mucosal barrier upregulated abundances Bacteroidota, Muribaculaceae, Lactobacillus, while it Firmicutes, NK4A136_group, Lachnospiraceae_NK4A136_group. supplementation modulated gut microbiota composition, increasing beneficial bacteria reducing detrimental ones, potentially contributing improved Conclusions: safeguard renal D-gal-exposed rats inhibiting mitophagy, function, regulating
Язык: Английский
Процитировано
1