Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Июнь 8, 2023
Abstract
Aging
is
characterized
by
systemic
chronic
inflammation,
which
accompanied
cellular
senescence,
immunosenescence,
organ
dysfunction,
and
age-related
diseases.
Given
the
multidimensional
complexity
of
aging,
there
an
urgent
need
for
a
systematic
organization
inflammaging
through
dimensionality
reduction.
Factors
secreted
senescent
cells,
known
as
senescence-associated
secretory
phenotype
(SASP),
promote
inflammation
can
induce
senescence
in
normal
cells.
At
same
time,
accelerates
immune
resulting
weakened
function
inability
to
clear
cells
inflammatory
factors,
creates
vicious
cycle
senescence.
Persistently
elevated
levels
organs
such
bone
marrow,
liver,
lungs
cannot
be
eliminated
leading
damage
aging-related
Therefore,
has
been
recognized
endogenous
factor
elimination
could
potential
strategy
anti-aging.
Here
we
discuss
at
molecular,
cellular,
organ,
disease
levels,
review
current
aging
models,
implications
cutting-edge
single
cell
technologies,
well
anti-aging
strategies.
Since
preventing
alleviating
diseases
improving
overall
quality
life
are
ultimate
goals
research,
our
highlights
critical
features
mechanisms
along
with
latest
developments
future
directions
providing
theoretical
foundation
novel
practical
Journal of Cachexia Sarcopenia and Muscle,
Год журнала:
2021,
Номер
12(3), С. 538 - 554
Опубликована: Май 5, 2021
Sarcopenia
is
a
progressive
and
widespread
skeletal
muscle
disease
that
related
to
an
increased
possibility
of
adverse
consequences
such
as
falls,
fractures,
physical
disabilities
death,
its
risk
increases
with
age.
With
the
deepening
understanding
sarcopenia,
has
become
major
clinical
elderly
key
challenge
healthy
ageing.
However,
exact
molecular
mechanism
this
still
unclear,
selection
treatment
strategies
evaluation
effect
are
not
same.
Most
importantly,
early
symptoms
obvious
easy
ignore.
In
addition,
manifestations
each
patient
exactly
same,
which
makes
it
difficult
effectively
study
progression
sarcopenia.
Therefore,
necessary
develop
use
animal
models
understand
pathophysiology
sarcopenia
therapeutic
strategies.
This
paper
reviews
mouse
can
be
used
in
including
ageing
models,
genetically
engineered
hindlimb
suspension
chemical
induction
denervation
immobilization
models;
analyses
their
advantages
disadvantages
application
scope;
finally
summarizes
models.
Pharmacological Research,
Год журнала:
2023,
Номер
189, С. 106687 - 106687
Опубликована: Фев. 4, 2023
Accumulating
evidence
indicates
gut
microbiota
contributes
to
aging-related
disorders.
However,
the
exact
mechanism
underlying
dysbiosis-related
pathophysiological
changes
during
aging
remains
largely
unclear.
In
current
study,
we
first
performed
remodeling
on
old
mice
by
fecal
transplantation
(FMT)
from
young
mice,
and
then
characterized
bacteria
signature
that
was
specifically
altered
FMT.
Our
results
revealed
FMT
significantly
improved
natural
systemic
disorders,
particularly
exerted
hepatoprotective
effects,
glucose
sensitivity,
hepatosplenomegaly,
inflammaging,
antioxidative
capacity
intestinal
barrier.
Moreover,
increased
abundance
of
A.muciniphila,
which
almost
nondetectable
in
mice.
Interestingly,
A.muciniphila
supplementation
also
similar
benefits
with
Notably,
targeted
metabolomics
short
chain
fatty
acids
(SCFAs)
only
acetic
acid
consistently
reversed
Then,
intervention
beneficial
actions
both
Caenorhabditis
elegans
conclusion,
our
study
demonstrated
disorders
through
its
derived
acid,
suggesting
interventions
potent
stimulative
A.
muciniphila
growth
production
alternative
effective
way
maintain
healthy
aging.
The
data
RNAseq
16
S
rRNA
gene
sequencing
can
be
accessed
NCBI
accession
number
PRJNA848996
PRJNA849355.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2020,
Номер
2020, С. 1 - 15
Опубликована: Июнь 17, 2020
Skin
aging
has
been
associated
with
a
higher
dietary
intake
of
carbohydrates,
particularly
glucose
and
galactose.
In
fact,
the
carbohydrates
are
capable
damaging
skin's
vital
components
through
nonenzymatic
glycation,
covalent
attachment
sugar
to
protein,
subsequent
production
advanced
glycation
end
products
(AGEs).
This
review
is
focused
on
role
D-galactose
in
development
skin
its
relation
oxidative
stress.
The
interest
this
problem
was
dictated
by
recent
findings
that
used
vitro
vivo
models.
highlights
advances
underlying
molecular
mechanisms
D-galactose-mediated
cell
senescence
cytotoxicity.
We
have
also
proposed
possible
impact
galactosemia
clinical
relevance.
understanding
mediated
can
help
dermatologists
optimize
methods
for
prevention
treatment
aging-related
diseases.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(22), С. 8653 - 8653
Опубликована: Ноя. 17, 2020
Anthocyanins
are
naturally
occurring
polyphenols
commonly
found
in
fruits
and
vegetables.
Numerous
studies
have
described
that
anthocyanin-rich
foods
may
play
a
crucial
role
the
prevention
treatment
of
different
pathological
conditions,
which
encouraged
their
consumption
around
world.
exhibit
significant
neuroprotective
role,
mainly
due
to
well-recognized
antioxidant
anti-inflammatory
properties.
Neuroinflammation
is
an
intricate
process
relevant
both
homeostatic
circumstances.
Since
progression
several
neurological
disorders
relies
on
neuroinflammatory
process,
targeting
brain
inflammation
has
been
considered
promising
strategy
those
conditions.
Recent
data
shown
anti-neuroinflammatory
abilities
many
anthocyanins
metabolites
onset
development
disorders.
In
this
review,
it
will
be
discussed
importance
applicability
these
polyphenolic
compounds
as
agents
also
scrutinized
molecular
mechanisms
underlying
modulation
neuroinflammation
by
natural
context
diseases.
Biomedicine & Pharmacotherapy,
Год журнала:
2021,
Номер
137, С. 111374 - 111374
Опубликована: Фев. 18, 2021
Astaxanthin
(ATX)
is
a
red
pigment
carotenoid
present
in
shrimp,
salmon,
crab,
and
asteroidean.
Several
studies
have
corroborated
the
anti-oxidant
efficacy
of
ATX.
In
addition,
ATX
has
anti-inflammatory,
anti-apoptotic
anti-proliferative
properties.
review,
we
discuss
role
Nrf2
mediating
anti-cancer,
anti-aging,
neuroprotective,
lung-protective,
skin-protective,
cardioprotective,
hepatoprotective,
anti-diabetic
muscloprotective
effects
Experimental Gerontology,
Год журнала:
2022,
Номер
163, С. 111769 - 111769
Опубликована: Март 22, 2022
Aging
is
an
inevitable
and
complicated
process
involving
many
physiological
changes.
Screening
of
natural
biologically
active
anti-aging
substances
a
current
research
hotspot.
Phlorizin
(PZ),
important
dihydrochalcone
phytoconstituent,
has
been
demonstrated
to
have
antioxidant
anti-tumor
effects.
In
this
paper,
different
doses
PZ
(20
40
mg/kg)
were
used
the
protective
effect
on
D-galactose
(D-gal)-induced
aging
mice.
Following
hematoxylin
eosin
staining
by
observing
hippocampus,
we
found
that
alleviated
damage
caused
D-gal
in
neuronal
cells,
while
enhanced
learning
memory
abilities
mice
radical
eight-arm
maze.
order
explain
reasons
for
these
effects,
tested
enzyme
activity
malonic
dialdehyde
concentration
mouse
serum,
liver,
brain
tissue.
The
contents
proteins
related
anti-inflammation
apoptosis
tissue
analyzed,
gut
microbiota
was
also
analyzed.
results
indicated
improved
significantly
reducing
content.
Western
blotting
analysis
suggested
effectively
neuro-apoptosis
via
regulating
expressions
Bax,
Bcl-2,
caspase-3.
exerted
effects
interleukin-1β/inhibitor
nuclear
factor
kappa
B
alpha/nuclear
kappa-light-chain-enhancer
activated
B-cells
signaling
pathways
tissues.
Importantly,
structure
diversity
microbiota,
microbiota-gut-brain
axis
may
hold
key
role
PZ-induced
conclusion,
can
be
as
potential
drug
candidate
combat
aging.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(14), С. 7781 - 7781
Опубликована: Июль 14, 2022
Aging
is
a
multi-factorial
process
developing
through
complex
net
of
interactions
between
biological
and
cellular
mechanisms
it
involves
oxidative
stress
(OS)
as
well
protein
glycation.
The
aim
the
present
work
was
to
verify
protective
role
Quercetin
(Q),
polyphenolic
flavonoid
compound,
in
d-Galactose
(d-Gal)-induced
model
aging
human
erythrocytes.
anion-exchange
capability
Band
3
(B3p)
measured
by
rate
constant
SO42−
uptake,
thiobarbituric
acid
reactive
substances
(TBARS)
levels—a
marker
lipid
peroxidation—total
sulfhydryl
(-SH)
groups,
glycated
hemoglobin
(A1c),
reduced
glutathione/oxidized
glutathione
(GSH-GSSG)
ratio
were
determined
following
exposure
erythrocytes
100
mM
d-Gal
for
24
h,
with
or
without
pre-incubation
10
µM
Q.
results
confirmed
that
activated
OS
pathways
erythrocytes,
affecting
both
membrane
lipids
proteins,
denoted
increased
TBARS
levels
decreased
total
respectively.
In
addition,
led
an
acceleration
uptake
B3p.
Both
alteration
B3p
function
damage
have
been
improved
pre-treatment
Q,
which
preferentially
ameliorated
peroxidation
rather
than
oxidation.
Moreover,
Q
prevented
A1c
formation,
while
no
effect
on
endogenous
antioxidant
system
observed.
These
findings
suggest
could
be
novel
potential
target
treatments
counteract
aging-related
disturbances.
Further
studies
are
needed
confirm
possible
pharmacological
strategies
against
aging.
Theranostics,
Год журнала:
2022,
Номер
12(17), С. 7550 - 7566
Опубликована: Янв. 1, 2022
Rational:
Senescence
is
a
major
aging
process
that
contributes
to
the
development
of
cardiovascular
diseases,
but
underlying
molecular
mechanisms
remain
largely
unknown.One
reason
due
lack
suitable
animal
models.We
aimed
generate
cardiomyocyte
(CM)-specific
senescent
model,
uncover
mechanisms,
and
develop
new
therapies
for
associated
cardiac
dysfunction.
Methods:The
gain/loss
circHIPK3
approach
was
used
explore
role
in
(CM)
senescence.To
investigate
function
senescence,
we
generated
CM-specific
tamoxifen-induced
knockout
(CKO)
mice.We
also
applied
various
analyses
including
PCR,
Western
blot,
nuclear
cytoplasmic
protein
extraction,
immunofluorescence,
echocardiography,
RNA
immunoprecipitation
assay,
RNA-pulldown
co-immunoprecipitation.Results:
Our
novel
CKO
mice
exhibited
worse
function,
decreased
expression
telomere
length
shortening
heart.The
level
senescence-inducer
p21
hearts
significantly
increased
survival
poor
compared
with
control
mice.In
vitro,
CMs
by
overexpression,
silencing.We
showed
scaffold
mRNA-binding
HuR
E3
ubiquitin
ligase
β-TrCP.circHIPK3
silencing
weakened
interaction
between
β-TrCP,
reduced
ubiquitination,
enhanced
mRNA.Moreover,
found
injected
human
umbilical
cord
mesenchymal
stem
cell-derived
exosomes
(UMSC-Exos)
levels,
levels
p21,
longer
length,
good
function.However,
these
beneficial
effects
exerted
UMSC-Exos
were
inhibited
circHIPK3.Conclusions:
We
successfully
research.Our
results
deletion
led
exaggerated
CM
senescence
function.As
scaffold,
binding
β-TrCP
cytoplasm,
leading
ubiquitination
degradation
activity.In
addition,
an
anti-senescence
cardio-protective
effect
delivering
circHIPK3.These
findings
pave
way
