Biogerontology, Год журнала: 2024, Номер 26(1)
Опубликована: Ноя. 15, 2024
Язык: Английский
Research, Год журнала: 2025, Номер 8
Опубликована: Янв. 1, 2025
The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.
Язык: Английский
Процитировано
2
Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2023, Номер 33(8), С. 1490 - 1500
Опубликована: Май 15, 2023
Over the past years, interest in chrono-nutrition has grown enormously as fundamental role of circadian rhythms regulating most physiological and metabolic processes become clearer. Recently, influence on gut microbiota (GM) composition also emerged, more than half total microbial fluctuates rhythmically throughout day. At same time, other studies have observed that GM itself synchronises host's biological clock through signals a different nature. Therefore, it been hypothesised there is two-way communication between host GM, but researchers only just begun to identify some its action mechanisms. The manuscript aim is, therefore, gather combine latest evidence field with recent research order investigate their relationship potential impact human health.Considering current evidence, desynchronization closely associated an alteration abundance functionality consequent deleterious effects health, such increased risk numerous pathologies, including cardiovascular disease, cancer, irritable bowel depression. A key maintaining balance seems be attributed meal-timing diet quality, well certain metabolites, particular short-chain fatty acids.Future are needed decipher link specific patterns relation disease frameworks.
Язык: Английский
Процитировано
34
Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(12), С. 4667 - 4687
Опубликована: Авг. 14, 2023
The blood–brain barrier (BBB) impairment plays a crucial role in the pathological processes of aging-accompanied neurological diseases (AAND). Meanwhile, circadian rhythms disruption and gut microbiota dysbiosis are associated with increased morbidity accelerated aging population. Importantly, also known to induce generation toxic metabolites pro-inflammatory cytokines, resulting BBB integrity. Collectively, this provides new perspective for exploring relationship among rhythms, microbes, diseases. In review, we focus on recent advances interplay between rhythm disturbances dysbiosis, their potential roles that occurs AAND. Based existing literature, discuss propose mechanisms underlying damage induced by dysregulated microbiota, which would serve as basis developing interventions protect population through targeting exploiting its links treating
Язык: Английский
Процитировано
22
AJP Renal Physiology, Год журнала: 2024, Номер 326(3), С. F382 - F393
Опубликована: Янв. 4, 2024
Circadian rhythms are endogenous biological oscillations that regulate various physiological processes in organisms, including kidney function. The plays a vital role maintaining homeostasis by regulating water and electrolyte balance, blood pressure, excretion of metabolic waste products, all which display circadian rhythmicity. For this reason, studying the regulation is important, time day experimental variable must be considered. Over past decade, considerable progress has been made understanding molecular mechanisms underlying within kidney. In review, current knowledge regarding explored, focusing on clock machinery, control renal functions, impact disrupted health. addition, parameters should considered future directions outlined review.
Язык: Английский
Процитировано
6
Cells, Год журнала: 2023, Номер 12(9), С. 1237 - 1237
Опубликована: Апрель 25, 2023
Although previously restricted to a limited number of medical conditions, there is growing appreciation that 'autoimmune' (or immune-mediated) processes are important aspects wide array diverse including cancers, neurodegenerative diseases and psychiatric disorders. All these classes conditions associated with alterations in mitochondrial function across an cell types. Accumulating data indicate the presence melatonergic pathway possibly all body cells, consequences for pathways crucial driving CD8+ T B-cell 'autoimmune'-linked processes. Melatonin suppression coupled upregulation oxidative stress suppress PTEN-induced kinase 1 (PINK1)/parkin-driven mitophagy, raising levels major histocompatibility complex (MHC)-1, which underpins chemoattraction cells activation antibody-producing B-cells. Many factors closely autoimmunity, gut microbiome/permeability, circadian rhythms, aging, aryl hydrocarbon receptor, brain-derived neurotrophic factor (BDNF) its receptor tyrosine B (TrkB) interact pathway. A future research directions novel treatment implications indicated this collection poorly conceptualized treated presentations. It proposed etiology many 'autoimmune'/'immune-mediated' disorders should be as significantly determined by dysregulation, being aspect pathoetiologies.
Язык: Английский
Процитировано
14
Circulation Research, Год журнала: 2024, Номер 134(6), С. 727 - 747
Опубликована: Март 14, 2024
The blood-brain barrier (BBB) is a critical interface separating the central nervous system from peripheral circulation, ensuring brain homeostasis and function. Recent research has unveiled profound connection between BBB circadian rhythms, endogenous oscillations synchronizing biological processes with 24-hour light-dark cycle. This review explores significance of rhythms in context functions, an emphasis on substrate passage through BBB. Our discussion includes efflux transporters molecular timing mechanisms that regulate their activities. A significant focus this potential implications chronotherapy, leveraging our knowledge for improving drug delivery to brain. Understanding temporal changes can lead optimized administration, enhance therapeutic efficacy neurological disorders while reducing side effects. By elucidating interplay transport across BBB, offers insights into innovative interventions.
Язык: Английский
Процитировано
4
Nature Reviews Urology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 14, 2024
Язык: Английский
Процитировано
4
Theoretical and Natural Science, Год журнала: 2025, Номер 75(1), С. 34 - 40
Опубликована: Янв. 8, 2025
Human beings exist in a 24-hour cycle where day and night alternate daily pattern. Circadian rhythms, which connects the body environment successfully, have developed nearly all living organisms. The suprachiasmatic nucleus (SCN), circadian timer situated hypothalamus, aligns our internal biological clocks with Earths day-night cycle. This synchronization is achieved through pathway from retina. These rhythms regulate wide array of physiological processes, such as hunger, sleep patterns, physical activity, hormone. It noteworthy that mood also exhibits pattern, disturbances system are associated mood-related issues. People depression frequently exhibit irregularities their sleep, appetite, activity levels, cortisol release, indicating stability key contributor to onset processes depressive disorders. article reviews recent research findings both humans animal models connect disrupted Understanding this link could lead innovative therapeutic approaches, treatments aimed at restoring rhythm integrity, may open doors for preventive measures targeting those risk Continued area holds promise improving mental health outcomes by addressing underlying mechanisms tied regulation
Язык: Английский
Процитировано
0
European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177290 - 177290
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Biological Rhythm Research, Год журнала: 2025, Номер unknown, С. 1 - 22
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0