Clinics and Practice,
Год журнала:
2025,
Номер
15(3), С. 54 - 54
Опубликована: Март 7, 2025
Background/Objectives:
During
the
last
decade,
there
has
been
an
increased
interest
in
phenolic
compound-rich
natural
products
as
therapies
for
regulating
molecular
pathways
behind
central
obesity
and
associated
metabolic
disorders.
The
present
scoping
review
presents
outcomes
of
clinical
preclinical
studies
examining
anti-obesity
effects
high
extra
virgin
olive
oil
(HP-EVOO)
its
possible
underlying
mechanisms.
Methods:
Studies
published
between
2014
2024
were
searched
via
MEDLINE,
Scopus,
Cochrane,
Web
Science,
Semantic
Scholar,
Google
Science.gov,
Clinicaltrials.gov
databases.
A
combination
keywords
Boolean
logic
was
used
to
search
throughout
decade
all
databases,
including
“hyperglycemia”
or
“hypertension”
“metabolic
syndrome”
“dyslipidemia”
“hyperlipidemia”
“hypoglycemia”
“obesity”
“macrovascular
diabetic
complications”
“microvascular
“cardiovascular
disease”
“overweight”
“insulin
sensitivity”
resistance”
“extra
oil”
“high
“human”
“animal
model”.
Results:
10-year
literature
survey
identified
21
both
animal
models
humans,
indicating
that
HP-EVOO
improves
inflammation,
glycemic
control,
oxidative
stress
endothelial
function,
potentially
protecting
against
syndrome,
hypertension
type
2
diabetes,
even
compared
EVOO.
Moreover,
HP-EVOO’s
antiplatelet
effect
improvement
HDL
functionality
reduce
cardiovascular
risk.
Conclusions:
evidence
presented
this
study
demonstrates
represents
effective
preventive
therapeutic
dietary
approach
cardiometabolic
diseases.
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 7, 2024
Background
Although
Spain
has
traditionally
followed
the
Mediterranean
diet,
in
recent
years,
changes
have
become
noticeable
food
preferences
of
population.
These
include
adopting
new
diets
and
dietary
trends,
such
as
plant-based
diets,
intermittent
fasting
raw
diets.
choices
are
influenced
by
cultural,
social
socio-demographic
factors,
their
impact
on
health
should
be
studied
detail.
Aim
The
objectives
this
research
are:
(1)
to
study
prevalence
different
patterns
among
Spanish
population,
(2)
explore
dependence
choice
(3)
investigate
relationship
between
habits
lifestyle
population
how
it
affects
health.
Methods
A
descriptive
cross-sectional
was
carried
out
Using
a
questionnaire
constructed
validated
team,
data
were
collected
nutritional,
targeted
explored.
Results
valid
sample
22,181
people
which
17,573
(79.2%)
claimed
follow
pattern,
1,425
(6.4%)
365
(1.6%)
vegans,
1,018
(4.6%)
practiced
fasting,
252
(1.1%)
diet
1,548
(7%)
other
types
show
that
younger
(18–25
years
old)
tend
adopt
more
often
than
older
women
type
men.
On
hand,
men
seem
practice
frequently.
higher
tendency
found
living
villages
those
cities.
Moreover,
some
trends
regions
Spain,
with
greater
adherence
Catalonia,
while
is
common
Region
Murcia.
Finally,
results
indicate
individuals
who
pay
attention
experiment
various
generally
health-conscious.
This
reflected
adoption
healthier
behaviors,
exercising
reducing
intake
alcohol
sugary
drinks.
Journal of Food Composition and Analysis,
Год журнала:
2023,
Номер
123, С. 105541 - 105541
Опубликована: Июль 20, 2023
The
aim
of
the
study
was
to
estimate
dietary
exposure
main
macro
and
micro
elements
from
meals
typically
consumed
by
Mediterranean
population,
in
particular
Sicilian
samples
prepared
cooked
prior
analysis.
A
total
57
typical
were
analysed
for
4
elements:
Calcium
(Ca),
Potassium
(K),
Magnesium
(Mg)
Sodium
(Na)
13
Aluminium
(Al),
Arsenic
(As),
Cadmium
(Cd),
Cobalt
(Co),
Chromium
(Cr),
Copper
(Cu),
Iron
(Fe),
Mercury
(Hg),
Manganese
(Mn),
Nickel
(Ni),
Lead
(Pb),
Zinc
(Zn)
Vanadium
(V)
inductively
coupled
plasma
-
mass
spectrometry
atomic
absorption
spectrometry.
concentration
quantified
directly
on
food
using
DMA-80
(Direct
Analysis).
Daily
Estimated
Element
Intake
calculated
essential
element
assessment
health
risk
associated
with
intake
investigated
performed.
In
particular,
supply
3.7
62%
sodium,
0.05–19%
potassium,
0.1-3.2%
calcium,
1.6-16%
magnesium,
2.1-37%
iron,
0.7-48%
zinc
0.98-339%
chromium.
some
foods
are
lacking
all
macroelements
(Na,
K,
Ca,
Mg).
quantity
taken
a
single
portion
100
grams
several
food,
compared
recommended
quantities,
is
low,
but
it
should
be
considered
that
average
one
day
(breakfast,
lunch
dinner),
undoubtedly,
inhabitants
area
consume
much
higher
quantities
500-1000
grams,
therefore,
this
confirmation
populations
concerned,
low
probability
nutritional
or
risks
due
consumption
foods,
indeed,
has
not
shown
assessments
heavy
metals.
Biomedicines,
Год журнала:
2023,
Номер
11(11), С. 2993 - 2993
Опубликована: Ноя. 7, 2023
Dopamine
regulates
several
functions,
such
as
voluntary
movements,
spatial
memory,
motivation,
sleep,
arousal,
feeding,
immune
function,
maternal
behaviors,
and
lactation.
Less
clear
is
the
role
of
dopamine
in
pathophysiology
type
2
diabetes
mellitus
(T2D)
chronic
complications
conditions
frequently
associated
with
it.
This
review
summarizes
recent
evidence
on
regulating
insular
metabolism
activity,
traditional
T2D,
pathophysiological
interconnection
between
T2D
neurological
psychiatric
disorders
characterized
by
impaired
activity/metabolism,
therapeutic
implications.
Reinforcing
signaling
especially
patients
dopamine-related
disorders,
Parkinson’s
Huntington’s
diseases,
addictions,
attention-deficit/hyperactivity
disorder.
On
other
hand,
although
specific
trials
are
probably
needed,
certain
medications
approved
for
(e.g.,
metformin,
pioglitazone,
incretin-based
therapy,
gliflozins)
may
have
a
due
to
anti-inflammatory
anti-oxidative
effects,
improvement
insulin
signaling,
neuroinflammation,
mitochondrial
dysfunction,
autophagy,
apoptosis,
restoration
striatal
synthesis,
modulation
reward
hedonic
eating.
Last,
targeting
could
potential
diagnostic
purposes
diabetes-related
complications,
diabetic
retinopathy.
Biomolecules,
Год журнала:
2024,
Номер
14(4), С. 478 - 478
Опубликована: Апрель 14, 2024
Metabolic
syndrome
(MS)
is
defined
by
the
outcome
of
interconnected
metabolic
factors
that
directly
increase
prevalence
obesity
and
other
diseases.
Currently,
considered
one
most
relevant
topics
discussion
because
an
epidemic
heave
incidence
in
both
developing
underdeveloped
countries
has
been
reached.
According
to
World
Obesity
Atlas
2023
report,
38%
world
population
are
presently
either
obese
or
overweight.
One
causes
imbalance
energy
intake
expenditure,
where
nutritional
due
consumption
high-calorie
fast
foods
play
a
pivotal
role.
The
dynamic
interactions
among
different
risk
highly
complex;
however,
underpinnings
hyperglycemia
dyslipidemia
for
recognized.
Fast
foods,
primarily
composed
soluble
carbohydrates,
non-nutritive
artificial
sweeteners,
saturated
fats,
complexes
macronutrients
(protein-carbohydrate,
starch-lipid,
starch-lipid-protein)
provide
high
calories.
Several
experimental
studies
have
pointed
out
dairy
proteins
peptides
may
modulate
activities
obesity.
To
justify
results
precisely,
from
milk
were
synthesized
under
vitro
conditions
their
contributions
biomarkers
assessed.
Comprehensive
information
about
impact
milks
on
food-induced
presented
this
narrative
review
article.
Frontiers in Bioscience-Landmark,
Год журнала:
2024,
Номер
29(10)
Опубликована: Сен. 26, 2024
Since
2000s,
we
have
outlined
the
multifaceted
role
of
inflammation
in
several
aspects
cancer,
via
specific
inflammatory
mediators,
including
platelet
activating
factor
(PAF)
and
PAF-receptor
(PAFR)
related
signaling,
which
affect
important
junctions
cellular
interactions
that
are
associated
with
tumor-related
manifestations.
It
is
now
well
established
disease-related
unresolved
chronic
responses
can
promote
carcinogenesis.
At
same
time,
tumors
themselves
able
to
their
progression
metastasis,
by
triggering
an
inflammation-related
vicious
cycle,
PAF
its
signaling
play
crucial
role(s),
usually
conclude
tumor
growth
angiogenesis.
In
parallel,
new
evidence
suggests
also
interact
cancer
treatments
inducing
antitumor
immune
response
or,
conversely,
promoting
recurrence.
Within
this
review
article,
current
knowledge
future
perspectives
implication
all
these
thoroughly
re-assessed.
The
potential
beneficial
PAF-inhibitors
natural
or
synthetic
modulators
PAF-metabolism
against
tumors,
metastasis
evaluated.
Emphasis
given
molecules
dual
anti-PAF
anti-cancer
activities
(Bio-DAPAC-tives),
proven
potency
through
clinical
trials,
as
on
metal-based
anti-inflammatory
mediators
constitute
a
class
potent
inhibitors.
way
compounds
may
anti-tumor
effects
modulate
actions
discussed.
Limitations
targeting
PAF,
metabolism
receptor,
PAF-related
part(s)
strategies
involve
response(s)
for
improved
outcome,
Nutrients,
Год журнала:
2024,
Номер
16(22), С. 3886 - 3886
Опубликована: Ноя. 14, 2024
Background/Objectives:
The
goal
of
this
pilot
study
is
to
evaluate
adherence
the
Mediterranean
Food
Pattern
(MFP)
in
a
self-selected
sample
university
students,
addressing
perspective
food
sustainability.
In
addition,
it
seeks
relate
MFP
with
sociodemographic
characteristics
and
nutritional
status.
Methods:
This
cross-sectional
whose
data
collection
was
carried
out
by
an
online
questionnaire
between
January
April
2023.
Results:
Two
hundred
forty-eight
students
participated—most
them
were
female
(78.2%),
had
median
22
(20;
30)
years,
resided
central
region
Portugal
(42.3%),
pursuing
degree
(73.4%)
public
higher
education
institution
(66.5%).
prevalence
overweight
(overweight
obesity)
found
33.1%.
Females
predominantly
used
olive
oil
as
their
main
source
fat
(95.9%,
p
=
0.009)
consumption
sugary
drinks
(81.4%,
0.004)
compared
males,
who
reported
usage
rates
85.2%
63.0%,
score
Diet
Adherence
Screener
7
points,
presented
interquartile
range
(Q1:
6,
Q3:
8),
indicating
moderate
adherence.
analysis
showed
no
differences
sexes
(p
0.087).
There
also
negative
correlation
body
mass
index
0.007;
r
−0.171).
associated
area
course
attended,
health-related
fields
showing
Conclusions:
These
findings
underscore
necessity
for
targeted
interventions
aimed
at
promoting
among
which
could
contribute
improved
health
outcomes
enhanced
environmental
Abstract
Portugal
is
influenced
by
the
Atlantic
Ocean
to
west
and
Mediterranean
Sea
south.
Thus,
dietary
patterns
in
include
both
diet
(MD)
(AD).
This
review
examines
characteristics
of
diets,
highlighting
their
commonalities
unique
features.
descriptive
literature
analyses
scientific
articles
on
MD
AD.
It
addresses
health
effects
diets
based
published
evidence.
includes
a
15
studies
specifically
focused
Portuguese
population.
Most
were
conducted
with
younger
people
(children
or
adolescents)
older
people,
some
made
patients
suffering
from
specific
pathology,
like
heart
disease,
AIDS,
macular
degeneration.
Both
emphasize
natural,
local,
seasonal
foods
prepared
using
traditional
methods.
They
consist
rich
macronutrients,
micronutrients,
bioactive
compounds
that
offer
benefits.
AD
are
recommended
as
healthy
associated
physical
activity
fundamental
elements
lifestyle
promoting
general
well-being.
While
have
been
extensively
studied,
remains
under-researched.
Nutrients,
Год журнала:
2025,
Номер
17(2), С. 256 - 256
Опубликована: Янв. 11, 2025
Background:
Metabolic
syndrome
(MS)
is
a
combination
of
comorbidities
that
increase
pro-inflammatory
cytokines
(PIC)
production,
with
subsequent
body
composition
(BC)
abnormalities
and
high
cardiovascular
risk.
Treatment
diet
exercise
has
been
suggested
as
possible
non-pharmacological
adjuvant
treatment.
Objective:
To
determine
changes
in
BC
PIC
patients
MS
after
Mediterranean-type
(MedDiet)
and/or
isokinetic
(IE).
Methods:
A
controlled
randomized
clinical
trial
was
conducted
at
third-level
hospital
Mexico
City.
Intervention
groups:
G1:
MedDiet
+
IE;
G2:
G3:
MedDiet;
G4:
control.
Anthropometry,
BC,
were
collected
from
the
baseline
12
weeks
post-intervention.
estimated
24-h
recall
record.
IE
consisted
standard
high-intensity
anaerobic
program.
Results:
Forty-two
aged
18–65
years
old
included.
The
most
frequent
obesity,
insulin
resistance,
dyslipidemia.
After
6
months
intervention,
significant
reduction
resistin
observed
within
group
IE,
whereas
former
also
showed
an
adiponectin.
Interventions
decrease
IL-10.
Regarding
all
groups
increased
resistance
values
relation
to
but
lower
than
control
group.
Conclusions:
results
suggest
have
selective
impact
on
mediators,
while
may
induce
only
minor
BC.
European Journal of Investigation in Health Psychology and Education,
Год журнала:
2025,
Номер
15(2), С. 11 - 11
Опубликована: Янв. 24, 2025
This
study
used
Explainable
Artificial
Intelligence
(XAI)
with
SHapley
Additive
exPlanations
(SHAP)
to
examine
dietary
and
lifestyle
habits
in
the
Spanish
population
identify
key
diet
predictors.
A
cross-sectional
design
was
used,
employing
validated
NutSo-HH
scale
gather
data
on
nutrition,
lifestyle,
socio-demographic
factors.
The
CatBoost
method
combined
SHAP
applied.
sample
included
22,181
adults:
17,573
followed
Mediterranean
diet,
1425
were
vegetarians,
365
vegans,
1018
practiced
intermittent
fasting.
Fish
consumption
strongest
indicator,
vegans
abstaining
some
vegetarians
consuming
it
occasionally.
Age
influenced
diet:
younger
individuals
preferred
vegan/vegetarian
diets,
while
older
adults
adhered
diet.
Vegans
consumed
less
junk
food,
fasters
more
physically
active.
model
effectively
predicts
but
struggles
others
due
imbalance,
highlighting
need
for
larger
studies
plant-based
fasting
diets.