Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2024, Номер 34(12), С. 2713 - 2719
Опубликована: Июль 24, 2024
Язык: Английский
Experimental Gerontology, Год журнала: 2023, Номер 179, С. 112253 - 112253
Опубликована: Июль 13, 2023
Frailty is a common geriatric syndrome characterized by increased vulnerability and associated with adverse clinical events such as falls, hospitalization, death. Early diagnosis early intervention can delay or reverse frailty ensure the healthy aging of older individuals. At present, there are no gold standard biomarkers for frailty, which mainly relies on scale to assess has shortcomings lagging assessment, subjectivity, poor consistency. help in frailty. The purpose this review summarize existing inflammatory markers focus novel that be used identify explore potential targets.
Язык: Английский
Процитировано
30
Immunity & Ageing, Год журнала: 2024, Номер 21(1)
Опубликована: Янв. 6, 2024
Abstract Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and considered an important indicator of adverse events in older population. Therefore, there growing interest early diagnosis intervention frailty, but cellular mechanisms responsible for frailty are still not completely understood. Chronic inflammation related to function increased disease risk. Additionally, multiple human animal studies suggest that probably plays largest role contributing frailty. Some inflammatory markers have been proposed predict However, large gaps knowledge clinical application these frail patients. understanding biological processes identifying recognized reliable urgent pivotal tasks geriatricians. In present review, we broadly summarize may potential diagnostic therapeutic use, thereby translating them into people near future.
Язык: Английский
Процитировано
16
Frontiers in Public Health, Год журнала: 2024, Номер 12
Опубликована: Июль 31, 2024
Objective This study aimed to evaluate the association between six complete blood count (CBC)-derived inflammatory markers [neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), systemic immune-inflammatory index (SII), response (SIRI), and pan-immune inflammation value (PIV)] risk of frailty mortality. Methods Data were obtained from National Health Nutrition Examination Survey (NHANES) 1999–2018. Mortality was identified using Death Index until December 31, 2019. Multiple logistic regression analysis conducted CBC-derived frailty. The Cox model assessed mortality in frail populations. Restricted cubic spline (RCS) used visualize with risk. predictive for further a random survival forest (RSF) approach. Results analyzed data total 16,705 middle-aged older participants. Among them, 6,503 participants frail, rate 41.47%. showed that NLR, MLR, PLR, SII, SIRI, PIV positively associated revealed highest quartile had significantly increased death compared those lowest quartile: NLR (HR = 1.73, 95% CI:1.54, 1.94), MLR 1.71, CI:1.51, 1.93), PLR 1.28, 95%CI: 1.15, 1.43), SII 1.50, 95%CI:1.34, 1.68), SIRI 1.88, CI 95%:1.67, 2.12), 1.55, 95%CI:1.38, 1.73). Random analyses demonstrated adult Conclusion results suggest are higher as well middle old-aged population United States.
Язык: Английский
Процитировано
12
npj Biomedical Innovations., Год журнала: 2025, Номер 2(1)
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
1
Molecular Aspects of Medicine, Год журнала: 2024, Номер 97, С. 101271 - 101271
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
9
Aging and Disease, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
In older adults, physical frailty and cognitive impairment contribute to adverse outcomes. However, the research on mechanisms underlying is limited. Low-grade chronic inflammation a characteristic of aging. Particularly, an imbalance in pro- anti-inflammatory may be involved neurodegenerative disorders. Therefore, exploring inflammatory markers crucial fully understanding these establishing substantial link between two Notably, few studies have focused both impairment, posing major challenge elucidating them. efforts are required for better prevention impairment. this review, we explored role as potential
Язык: Английский
Процитировано
3
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Ноя. 11, 2024
Sarcopenia is a significant healthcare challenge in the aging population. Oxidative stress (OS) acknowledged to play pivotal role pathological progression of sarcopenia. Numerous studies have demonstrated that mitigating or eliminating OS can ameliorate manifestations associated with However, current clinical antioxidant therapies often fall short anticipated outcomes. This bibliometric analysis aims delineate prevailing research trends, thematic emphases, focal points, and developmental trajectories within domain sarcopenia, while also endeavoring explore prospective anti-oxidative strategies for future interventions.
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4673 - 4673
Опубликована: Май 14, 2025
Metabolic-Associated Fatty Liver Disease (MAFLD) is a public health concern that constantly expanding, with fast-growing prevalence, and it affects about quarter of the world's population. This condition significant risk factor for cardiovascular, hepatic, oncologic diseases, such as hypertension, hepatoma, atherosclerosis. Sarcopenia was long considered to be an aging-related syndrome, but today, acknowledged secondarily related chronic diseases metabolic cardiovascular conditions, liver among other comorbidities associated insulin resistance inflammation, besides inactivity poor nutrition. The physiopathology involving MAFLD sarcopenia has still not been solved. Inflammation, oxidative stress, mitochondrial dysfunction, seem some keys this relationship since hormone target mainly skeletal muscle. review aimed comprehensively discuss main physiological pathways involved in these conditions. are interconnected by complex network pathophysiological mechanisms, resistance, muscle tissue production capacity, inflammatory state, which contributors relationship. In addition, clinical analysis, patients manifest more severe hepatitis fibrosis when compared only MAFLD. These patients, both disorders, also present improvement their treated sarcopenia, reinforcing association between them. Lifestyle changes accompanied non-pharmacological interventions, dietary therapy increased physical activity, undoubtedly improve scenario.
Язык: Английский
Процитировано
0
Current Developments in Nutrition, Год журнала: 2025, Номер unknown, С. 107479 - 107479
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
BioScience Trends, Год журнала: 2023, Номер 17(4), С. 262 - 270
Опубликована: Авг. 22, 2023
As people age, geriatric syndromes characterized by frailty significantly impact both clinical practice and public health. Aging weakens people's immune functions, leading to chronic low-grade inflammation that ultimately contributes the development of frailty. Effectively managing can help alleviate economic burden an aging population. This review delves into intricate relationship among aging, infection-induced inflammation, In addition, it analyzes various approaches interventions address frailty, such as smart rehabilitation programs stem-cell treatments, offering promising solutions in this new era. Given importance topic, further research mechanisms is crucial. Equally essential devising relevant measures delay its onset formulation comprehensive clinical, research, health strategies enhance quality life for elderly individuals.
Язык: Английский
Процитировано
6