GeroScience,
Год журнала:
2024,
Номер
46(6), С. 5629 - 5641
Опубликована: Июль 9, 2024
Abstract
Frailty
has
been
linked
to
inflammation
and
changes
in
body
composition,
but
the
findings
are
inconsistent.
To
explore
this,
we
used
Index
(FI)
definition
(1)
investigate
association
between
levels
of
inflammatory
markers
(baseline)
change
FI
score
after
8
years
follow-up
(2)
longitudinal
associations
markers,
frailty.
Home-dwelling
elderly
(≥
70
years)
were
invited
participate
study
re-invited
a
visit
later.
This
includes
total
133
participants.
The
included
high-sensitive
C-reactive
protein
(hs-CRP),
interleukin
6
(IL-6),
tumor
necrosis
factor
alpha
(TNF-α),
glycoprotein
acetyls
(Gp-acetyls).
We
composition
fat
mass,
fat-free
waist
circumference.
consisted
38
variables.
Additional
clinical
assessments
such
as
blood
pressure
mass
index
(BMI),
well
information
about
daily
medications,
collected
at
both
visits.
Linear
regression
model
Spearman’s
rank
correlation
associations.
showed
that
increased
years,
participants
with
higher
hs-CRP
baseline
had
largest
score.
Changes
significantly
correlated
IL-6,
circumference
TNF-α.
use
drugs
during
follow-up,
which
may
have
attenuated
However,
elevated
concentrations
be
associated
an
risk
frailty
subsequent
years.
Abstract
Global
population
aging
poses
a
tremendous
burden
on
the
health
care
system
worldwide.
Frailty
is
associated
with
decreased
physical
reserve
and
considered
an
important
indicator
of
adverse
events
in
older
population.
Therefore,
there
growing
interest
early
diagnosis
intervention
frailty,
but
cellular
mechanisms
responsible
for
frailty
are
still
not
completely
understood.
Chronic
inflammation
related
to
function
increased
disease
risk.
Additionally,
multiple
human
animal
studies
suggest
that
probably
plays
largest
role
contributing
frailty.
Some
inflammatory
markers
have
been
proposed
predict
However,
large
gaps
knowledge
clinical
application
these
frail
patients.
understanding
biological
processes
identifying
recognized
reliable
urgent
pivotal
tasks
geriatricians.
In
present
review,
we
broadly
summarize
may
potential
diagnostic
therapeutic
use,
thereby
translating
them
into
people
near
future.
Nutrients,
Год журнала:
2025,
Номер
17(2), С. 221 - 221
Опубликована: Янв. 8, 2025
Background/Objectives:
Malnutrition
and
frailty
are
independent
risk
factors
of
prolonged
hospitalization
mortality,
respectively.
However,
the
combined
association
these
conditions
with
mortality
in
hospitalized
elderly
patients
remains
unclear.
Our
object
was
to
investigate
malnutrition
on
patients.
Methods:
The
current
study
a
retrospective
analysis
470
admitted
geriatric
care
unit
tertiary
hospital
Taiwan
between
01
August
2019
31
March
2023.
Mini
Nutritional
Assessment-short
form
Clinical
Frailty
Scale
were
used
as
evaluation
tools
for
nutritional
status,
Patients
divided
into
four
groups
based
status.
investigated
using
multivariate
logistic
Cox
proportional
hazard
models
adjusting
potential
confounders.
Results:
Among
patients,
144
(31%)
exhibited
no
or
frailty,
146
but
46
(10%)
risk,
134
(28%)
both
frailty.
Compared
neither
condition,
those
had
higher
risks
(odds
ratio
3.23,
95%
confidence
interval
[CI]
1.68-6.12)
(hazard
4.33;
CI
2.01-9.34).
Conclusion::
co-occurrence
has
significant
detrimental
impacts
older
adults.
findings
this
emphasize
importance
early
screening
intervention
among
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Апрель 8, 2024
Background
Frailty
is
a
significant
concern
in
the
field
of
public
health.
However,
currently,
there
lack
widely
recognized
and
reliable
biological
markers
for
frailty.
This
study
aims
to
investigate
association
between
systemic
inflammatory
biomarkers
frailty
older
adult
population
United
States.
Methods
employed
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2007
2018
conducted
rigorous
cross-sectional
analysis.
We
constructed
weighted
logistic
regression
models
explore
correlation
Systemic
Immune-Inflammation
Index
(SII),
Inflammatory
Response
(SIRI),
aged
40
80
years.
Using
restricted
cubic
spline
(RCS),
we
successfully
visualized
relationship
SII,
SIRI,
Finally,
presented
stratified
analyses
interaction
tests
covariates
forest
plot.
Results
involved
11,234
participants,
45.95%
male
54.05%
female,
with
an
average
age
64.75
±
0.13
After
adjusting
relevant
covariates,
model
indicated
odds
ratio
(OR)
95%
confidence
interval(CI)
natural
logarithm
(ln)
transformed
lnSII
lnSIRI
as
1.38
(1.24–1.54)
1.69
(1.53–1.88),
respectively.
Subsequently,
assessed
different
levels
lnSIRI,
finding
consistent
results.
In
group
model,
likelihood
significantly
increased
fourth
quartile
(OR
=
1.82,
CI:
1.55–2.12)
compared
second
quartile.
third
1.30,
1.10–1.53)
2.29,
1.95–2.70)
The
results
indicate
that
income-to-poverty
influence
RCS
demonstrated
nonlinear
lnSII,
Conclusion
this
positive
(SII,
SIRI)
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(9), С. 2686 - 2686
Опубликована: Май 2, 2024
Background:
Frailty
is
increasingly
recognized
as
a
significant
health
concern,
particularly
due
to
its
association
with
cardiovascular
pathologies.
This
study
aims
examine
how
vascular
endothelial
dysfunction,
known
premorbid
stage
in
the
pathophysiology
of
diseases,
contributes
link
between
illness
and
frailty.
Methods:
The
inclusion
criteria
allowed
us
focus
on
original
clinical
research
articles
published
English
January
2014
2024,
which
reported
quantitative
assessments
relationship
frailty
dysfunction.
Excluded
from
were
systematic
literature
reviews,
meta-analyses,
editorials,
conference
articles,
theses,
methodological
studies
using
animal
or
cell
culture
models.
Searches
conducted
electronic
databases,
including
Scopus,
ScienceDirect,
Medline,
up
22
2024.
risk
bias
was
assessed
Joanna
Briggs
Institute’s
critical
appraisal
tools.
methods
used
present
synthesize
results
involved
data
extraction
categorization
based
biomolecular
findings
Results:
Following
application
exclusion
criteria,
total
29
identified.
Vascular
dysfunction
associated
increased
phenotypes,
we
also
identified
SGLT-2
inhibitors’
potential
role
an
anti-fragility
treatment
that
affects
found
physical
markers
are
measures
have
predictive
value
for
incident
Furthermore,
some
shown
inflammation
impact
frailty,
innovative
age-related
chronic
measure
has
been
proven
predict
scores.
Conclusions:
current
evidence
suggests
highlighting
need
further
elucidate
underlying
mechanisms.
Journal of Ageing and Longevity,
Год журнала:
2025,
Номер
5(1), С. 4 - 4
Опубликована: Фев. 3, 2025
Age-related
declines
in
muscle
mass,
neuromuscular,
and
physical
function
can
be
mitigated
by
resistance
training
(RT).
Omega-3
polyunsaturated
fatty
acids
(Ω-3
PUFAs)
supplementation
has
shown
benefits
older
adults.
However,
it
remains
unclear
if
combining
Ω-3
PUFAs
with
RT
is
more
effective
than
alone
or
placebo.
This
systematic
review
meta-analysis
examined
the
effects
randomized
controlled
trials
(RCTs)
of
combined
compared
to
placebo
on
mass
healthy
adults
(≥65
y).
Databases
such
as
PubMed,
Embase,
SPORTDiscus,
Web
Science
were
searched
11
April
2024.
No
restriction
language
publication
date
was
implemented.
Mean
differences
(MDs)
standardized
mean
(SMDs)
95%
confidence
intervals
pooled
calculated.
Nine
studies
(n
=
286,
54%
men)
met
inclusion
criteria.
The
found
no
significant
effect
neuromuscular
but
a
large
chair-rise
performance.
Potential
impact
dose,
duration,
sex
not
observed.
Most
had
varying
levels
bias,
none
recommended
quality
standards
for
investigating
PUFAs,
findings
suggest
clear
advantage
RT.
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 385 - 385
Опубликована: Фев. 6, 2025
Background:
Vitamin
D
insufficiency/deficiency
is
a
highly
prevalent
condition
worldwide.
At
the
same
time,
chronic
inflammation
versatile
pathophysiological
feature
and
common
correlate
of
various
disorders,
including
vitamin
deficiency.
Methods:
We
investigated
possible
association
with
25-hydroxyvitamin
D3
(25OHD3)
levels
its
down-stream
pathway
by
exploring
D-binding
protein
(DBP)
receptor
(VDR)
genes
for
single-nucleotide
polymorphisms
(SNPs),
in
healthy
non-elderly
Bahraini
adults.
Plasma
25OHD3
were
measured
chemiluminescence,
six
SNPs,
four
GC
gene
(rs2282679AC,
rs4588CA,
rs7041GT,
rs2298849TC)
two
VDR
(rs731236TC
rs12721377AG)
genotyped
real-time
PCR.
The
concentrations
five
inflammatory
biomarkers,
IL6,
IL8,
procalcitonin
(PCT),
TREM1,
uPAR,
ELISA.
Results:
results
showed
no
between
level
any
markers’
levels.
However,
three
tested
SNPs
significantly
associated
biomarkers
except
IL6.
TT
mutant
genotype
rs2298849TC
was
lower
IL8
higher
PCT
AA
rs2282679AC
decreased
(p
≤
0.001)
increased
TREM1
=
0.005),
GG
wild
rs12721377AG
0.026).
Conclusions:
Although
not
system
blood,
it
downstream,
as
revealed
DBP
genotyping.
Alternatively,
pursue
other
functions
beyond
pathway.
