An emerging role of SNAREs in ischemic stroke: From pre-to post-diseases DOI Creative Commons
Yaxin Liu, Jung Hwa Hong, Guozuo Wang

и другие.

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116907 - 116907

Опубликована: Март 1, 2025

Ischemic stroke is a debilitating condition characterized by high morbidity, disability, recurrence, and mortality rates on global scale, posing significant threat to public health economic stability. Extensive research has thoroughly explored the molecular mechanisms underlying ischemic stroke, elucidating strong association between soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor proteins (SNAREs) pathogenesis of this condition. SNAREs, class highly conserved involved in membrane fusion, play crucial role modulating neuronal information transmission promoting myelin formation central nervous system (CNS). Preventing SNARE complex formation, malfunctions SNARE-dependent exocytosis, altered regulation SNARE-mediated vesicle fusion are linked excitotoxicity, endoplasmic reticulum (ER) stress, programmed cell death (PCD) stroke. However, its remain unclear. This study conducts comprehensive review existing literature proteins, encompassing structure, classification, expression family, as well assembly - disassembly cycle complexes their physiological roles CNS. We examine which SNAREs contribute pathological progression associated risk factors (hypertension, hyperglycemia, dyslipidemia, atherosclerosis). Furthermore, our findings highlight promise viable target for pharmacological interventions treatment

Язык: Английский

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects DOI Creative Commons

Qin Ru,

Yusheng Li,

Lin Chen

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Язык: Английский

Процитировано

50
Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials DOI Creative Commons
Xiaohang Guo, Weikang Luo,

Lingyu Wu

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Язык: Английский

Процитировано

34
MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1/NRF2 interaction DOI Creative Commons
Xing Luo, Yuehong Wang, Xinxin Zhu

и другие.

Redox Biology, Год журнала: 2023, Номер 69, С. 102987 - 102987

Опубликована: Дек. 7, 2023

Micheliolide (MCL), which is the active metabolite of parthenolide, has demonstrated promising clinical application potential. However, effects and underlying mechanisms MCL on atherosclerosis are still unclear.

Язык: Английский

Процитировано

37
Novel Multi-Antioxidant Approach for Ischemic Stroke Therapy Targeting the Role of Oxidative Stress DOI Creative Commons
Camilo Briones-Valdivieso,

Felipe Briones,

Sofía Orellana-Urzúa

и другие.

Biomedicines, Год журнала: 2024, Номер 12(3), С. 501 - 501

Опубликована: Фев. 23, 2024

Stroke is a major contributor to global mortality and disability. While reperfusion essential for preventing neuronal death in the penumbra, it also triggers cerebral ischemia-reperfusion injury, paradoxical injury primarily caused by oxidative stress, inflammation, blood–brain barrier disruption. An burst inflicts marked cellular damage, ranging from alterations mitochondrial function lipid peroxidation activation of intricate signalling pathways that can even lead cell death. Thus, given pivotal role stress mechanisms reinforcement antioxidant defence system has been proposed as protective approach. Although this strategy proven be successful experimental models, its translation into clinical practice yielded inconsistent results. However, should considered availability numerous molecules with wide range chemical properties affect extent injury; several groups molecules, including polyphenols, carotenoids, vitamins, among other compounds, mitigate damage intervening multiple at various stages. Multiple trials have previously conducted evaluate these using melatonin, acetyl-L-carnitine, chrysanthemum extract, edaravone dexborneol, saffron, coenzyme Q10, oleoylethanolamide, treatments. Therefore, multi-antioxidant therapy emerges promising novel therapeutic option due potential synergistic effect provided simultaneous roles individual compounds.

Язык: Английский

Процитировано

13
Ferritinophagy and Ferroptosis in Cerebral Ischemia Reperfusion Injury DOI Creative Commons
Xiaoyue Liu,

Can-Ming Xie,

Yao Wang

и другие.

Neurochemical Research, Год журнала: 2024, Номер 49(8), С. 1965 - 1979

Опубликована: Июнь 4, 2024

Abstract Cerebral ischemia–reperfusion injury (CIRI) is the second leading cause of death worldwide, posing a huge risk to human life and health. Therefore, investigating pathogenesis underlying CIRI developing effective treatments are essential. Ferroptosis an iron-dependent mode cell death, which caused by disorders in iron metabolism lipid peroxidation. Previous studies demonstrated that ferroptosis also form autophagic nuclear receptor coactivator 4(NCOA4) mediated ferritinophagy was found regulate interfering with metabolism. Ferritinophagy important pathogenic mechanisms CIRI. This review mainly summarizes link regulation between further discusses their In addition, potential treatment methods targeting for presented, providing new ideas prevention clinical future.

Язык: Английский

Процитировано

10
Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies DOI Creative Commons
Xiangjun Wang, Xiaowen Xia,

Xianliang Song

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 14, 2025

Premenstrual dysphoric disorder (PMDD) is a cyclical mood that severely affects the daily life of women reproductive age. Most medications being used clinically have limitations such as low efficacy, side effects, and high cost, so there an urgent need to discover safer more effective medications. Rutin natural flavonol glycoside with various pharmacological properties including antidepressant. The study efficacy mechanism action rutin in PMDD-depressed subtype model rats plays important role discovery new drugs for treatment PMDD. Binding gamma-aminobutyric acid type A receptors (GABAA receptors) was probed using molecular docking, microscale thermophoresis, radioactive receptor ligand binding assay cell membrane clamp experiment. Behavioral tests mice were performed screen optimal dose rutin. evaluate effects on depressed mood, memory impairment, social impairment rats. HE staining Golgi observe neuronal damage rat hippocampus. UHPLC-MS/MS targeted metabolomics detect changes neurotransmitter content PCR array effect mRNA expression GABAA partial subunits docking score benzodiazepine site -11.442 gliding -11.470. Kd (α1β2γ2) 1.17 ± 0.89 μM. competed [H3]-flunitrazepam inhibited inward flow chloride ions (P < 0.05). In rats, alleviated ameliorated hippocampal reduces (GABA) acetylcholine (ACh) levels Moreover, we found did not affect relative Overall, which may be related sites, inhibiting flow, ameliorating reducing GABA ACh levels. results this provide experimental basis scientific evidence development

Язык: Английский

Процитировано

1
Ginkgolide B binds to GPX4 and FSP1 to alleviate cerebral ischemia/reperfusion injury in rats DOI

Rong Zou,

Zhaoxia Liu, Peng Wang

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117237 - 117237

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Edaravone dextranol alleviates ferroptosis, Cuproptosis, and blood-brain barrier damage after acute cerebral infarction DOI
Guishan Jin, Wenfeng Han, Tingting Duan

и другие.

Metabolic Brain Disease, Год журнала: 2025, Номер 40(3)

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

1
Acteoside alleviates lipid peroxidation by enhancing Nrf2-mediated mitophagy to inhibit ferroptosis for neuroprotection in Parkinson's disease DOI
Han Zheng, Bao Wang, Yuqi Wen

и другие.

Free Radical Biology and Medicine, Год журнала: 2024, Номер 223, С. 493 - 505

Опубликована: Июль 24, 2024

Язык: Английский

Процитировано

7
Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review DOI Creative Commons
Nemanja Živanović, Marija Lesjak, Nataša Simin

и другие.

Antioxidants, Год журнала: 2024, Номер 13(3), С. 334 - 334

Опубликована: Март 10, 2024

Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.

Язык: Английский

Процитировано

5