Natural Resources for Human Health,
Год журнала:
2023,
Номер
4(1), С. 89 - 97
Опубликована: Дек. 14, 2023
<i>Melaleuca
cajuputi</i>
plant
has
piqued
the
interest
of
researchers
due
to
its
pharmacological
properties.
However,
there
is
scarce
information
regarding
enzyme
inhibitory
effects
and
possible
mechanism
action.
Thus,
this
study
aimed
investigate
antioxidant,
inhibitory,
potential
binding
interactions
bioactive
components
in
<i>M.
extract
fractions
with
target
enzymes.
The
1,1-diphenyl-2-picrylhydrazyl
radical
scavenging
(DPPH)
assay
was
used
for
antioxidant
activity.
inhibition
assessed
using
tyrosinase
acetylcholinesterase
(AChE)
methanolic
(MCME)
demonstrated
most
potent
activity
comparison
<i>Melaleuca</i>
fraction
(MF1)
(MF2),
as
evidenced
by
IC<sub>50</sub>
values
28.14
±
0.96,
35.26
0.64,
80.90
0.17
μg/mL,
respectively.
Similarly,
results
showed
that
MCME
(IC<sub>50</sub>
65.81±
0.39
μg/mL)
had
highest
potency
on
compared
MF1
131.3±
0.43
MF2
215.3
0.48
μg/mL).
3.35
0.37
a
remarkable
AChE
than
MF1.
On
other
hand,
possessed
low
toxicity
effect
an
LC<sub>50</sub>
781
0.07
whereas
were
non-toxic.
10-methylanthracene-9-carboxaldehyde,
2-isopropyl-10-methylphenanthrene,
2-tert
butylanthracene,
β-eudesmol,
α-eudesmol
strong
propensity
ranging
from
-5.1
-6.2
-6.4
-7.6
kcal/mol
towards
leaf
could
be
considered
novel
source
naturally
occurring
antioxidants
promising
inhibitors.
Arabian Journal of Chemistry,
Год журнала:
2023,
Номер
16(5), С. 104669 - 104669
Опубликована: Фев. 15, 2023
This
study
investigated
the
in
vitro
antioxidant
and
anticancer
properties
of
Fomitopsis
pinicola
extract
(EMFP).
The
activity
EFMP
was
analysed
via
free
radical
scavenging
(DPPH,
ABTS
Hydroxyl
radicals)
assay
a
protein
oxidation
assay.
effectively
scavenged
radicals
exhibited
remarkable
protection
against
oxidation.
proliferation
EMFP-treated
HepG2
cells
remarkably
decreased.
EMFP
increased
reactive
oxygen
species
(ROS)
production,
depleted
mitochondrial
membrane
potential
(MMP)
promoted
apoptosis
cells.
In
addition,
malondialdehyde
(MDA)
content
reduced
activities
SOD,
CAT
GPx
Using
UPLC-Triple-TOF-MS,
2
phenolic
compounds
14
triterpenes
were
identified.
These
may
be
primary
contributors
to
capacities
EMFP.
Together,
these
findings
highlight
possibility
exploiting
for
its
desired
pharmaceutical
ingredients.
Molecules,
Год журнала:
2024,
Номер
29(10), С. 2199 - 2199
Опубликована: Май 8, 2024
Schisandra
sphenanthera
Rehd.
et
Wils.,
as
a
traditional
Chinese
medicine,
has
important
medicinal
value.
In
the
market,
availability
of
fruit
S.
mainly
relies
on
wild
picking,
but
many
canes
and
leaves
are
discarded
during
collection,
resulting
in
waste
resources.
The
contain
various
bioactive
ingredients
can
be
used
spice,
tea,
medicine
so
present
great
utilization
opportunities.
Therefore,
it
is
helpful
to
explore
effective
components
biological
activities
utilize
fully.
this
study,
response
surface
method
with
ultrasound
was
extract
total
triterpenoids
from
at
different
stages.
content
stages
higher
than
that
canes.
had
strong
antioxidant
antibacterial
abilities.
At
same
time,
activity
against
Bacillus
subtilis
Pseudomonas
aeruginosa
stronger
Staphylococcus
aureus
Escherichia
coli.
This
study
provides
foundation
for
development
would
relieve
shortage
resources
sphenanthera.
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1526 - 1526
Опубликована: Дек. 13, 2024
This
study
provides
the
first
comprehensive
evaluation
of
bioactive
potential
acorn
flour
extracts
(Quercus
robur,
Fagaceae)
prepared
at
different
temperatures
(20,
60,
80
and
100
°C),
focusing
on
polyphenolic
content,
antioxidant
properties
enzyme
inhibitory
activities.
Through
HPLC-ESI-MS/MS
analysis,
36
compounds
were
identified,
with
extract
60
°C
showing
highest
concentrations
key
polyphenols,
notably
gallic
acid
(210,008.9
mg·kg−1)
ellagic
(45,469.6
mg·kg−1).
also
exhibited
a
high
activity
significant
inhibition
glucosidase
acetylcholinesterase,
suggesting
benefits
for
diabetes
management
neuroprotection.
The
results
indicate
that
extraction
temperature
affects
bioactivity,
standing
out
as
promising
candidate
nutraceutical,
pharmaceutical,
cosmeceutical
applications
due
to
its
rich
polyphenol
profile
potent
biological
properties.
Natural Resources for Human Health,
Год журнала:
2023,
Номер
4(1), С. 89 - 97
Опубликована: Дек. 14, 2023
<i>Melaleuca
cajuputi</i>
plant
has
piqued
the
interest
of
researchers
due
to
its
pharmacological
properties.
However,
there
is
scarce
information
regarding
enzyme
inhibitory
effects
and
possible
mechanism
action.
Thus,
this
study
aimed
investigate
antioxidant,
inhibitory,
potential
binding
interactions
bioactive
components
in
<i>M.
extract
fractions
with
target
enzymes.
The
1,1-diphenyl-2-picrylhydrazyl
radical
scavenging
(DPPH)
assay
was
used
for
antioxidant
activity.
inhibition
assessed
using
tyrosinase
acetylcholinesterase
(AChE)
methanolic
(MCME)
demonstrated
most
potent
activity
comparison
<i>Melaleuca</i>
fraction
(MF1)
(MF2),
as
evidenced
by
IC<sub>50</sub>
values
28.14
±
0.96,
35.26
0.64,
80.90
0.17
μg/mL,
respectively.
Similarly,
results
showed
that
MCME
(IC<sub>50</sub>
65.81±
0.39
μg/mL)
had
highest
potency
on
compared
MF1
131.3±
0.43
MF2
215.3
0.48
μg/mL).
3.35
0.37
a
remarkable
AChE
than
MF1.
On
other
hand,
possessed
low
toxicity
effect
an
LC<sub>50</sub>
781
0.07
whereas
were
non-toxic.
10-methylanthracene-9-carboxaldehyde,
2-isopropyl-10-methylphenanthrene,
2-tert
butylanthracene,
β-eudesmol,
α-eudesmol
strong
propensity
ranging
from
-5.1
-6.2
-6.4
-7.6
kcal/mol
towards
leaf
could
be
considered
novel
source
naturally
occurring
antioxidants
promising
inhibitors.
