Exploring anxiolytic peptides derived from walnut protein by an integrated approach of multivariate analysis, random forest methodology
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106271 - 106271
Опубликована: Фев. 1, 2025
Язык: Английский
Preparation and Encapsulation of DPP-IV Inhibitory Peptides: Challenges and Strategies for Functional Food Development
Rui Zhao,
Ye Zhou,
Huifang Shen
и другие.
Foods,
Год журнала:
2025,
Номер
14(9), С. 1479 - 1479
Опубликована: Апрель 24, 2025
Dipeptidyl
peptidase
IV
(DPP-IV)
inhibitory
peptides
have
emerged
as
promising
functional
ingredients
for
managing
type
2
diabetes
due
to
their
ability
enhance
insulin
secretion
and
improve
glycemic
control.
This
review
provides
a
concise
overview
of
current
strategies
the
preparation
encapsulation
DPP-IV
peptides,
with
focus
on
food
industry
application,
evaluating
bioinformatics
substrate
selection,
methods
like
mild
enzymatic
hydrolysis,
cost-effective
fermentation,
high-purity
chemical
synthesis
peptide
production.
Challenges
associated
incorporating
these
into
products
are
addressed,
including
impacts
sensory
properties,
stability
during
processing
digestion,
need
effective
delivery
systems
bioavailability.
Potential
solutions
targeted
release,
such
emulsions,
liposomes,
nanoparticles,
explored.
Future
research
directions
outlined,
emphasizing
necessity
scalable
production
methods,
co-encapsulation
strategies,
consumer
acceptance
studies
facilitate
commercialization
ingredients.
By
addressing
key
areas,
this
aims
provide
theoretical
foundation
practical
guidance
development
paving
way
broader
application
in
prevention
management
diabetes.
Язык: Английский
New Insights into the Active Structure of Casein-Derived Pentapeptide Ile-Pro-Ile-Gln-Tyr as a Dipeptidyl Peptidase IV Inhibitor In Vivo
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
This
study
investigated
the
metabolic
stability
of
casein-derived
peptide
IPIQY
and
its
active
fragments
in
relation
to
vivo
hypoglycemic
activity.
dose
dependently
inhibited
DPP-IV
activity
Caco-2
cells
(IC50
=
73.48
μM).
When
administered
at
300
μmol/kg,
reduced
intestinal
plasma
by
46.46%
13.75%,
respectively,
enhanced
insulin
levels
43.42%,
blood
glucose
37.77%
OGTT
mice.
Metabolic
results
showed
rapidly
entered
bloodstream
reaching
a
peak
concentration
0.51
μM
2
min
after
oral
administration
(300
μmol/kg).
It
was
stable
gastric
digestion
but
degraded
into
IPIQ
IPI
intestine.
Its
low
permeability
((4.40
±
0.18)
×
10-8
cm/s)
across
mainly
due
degradation
IP
BBM.
identified
as
most
metabolized
fragment.
The
peptides
IPIQY,
IPIQ,
IPI,
all
containing
fragment
exhibited
comparable
effects
vivo,
whereas
significantly
less
active.
Furthermore,
gastrointestinal
releases
contributing
superior
effect
via
compared
intravenous
injection.
These
findings
provide
new
insights
potential
routes
IPIQY.
Язык: Английский
Exploration of the Fasting Hypoglycemic Mechanism of Casein Hydrolysate Enriched with Glu/Gln and Glu/Gln-Containing Peptides in db/db Diabetic-like Mice Using Multiomics Analysis
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
The
fasting
hypoglycemic
effect
of
casein
hydrolysate
(CH)
was
investigated
in
db/db
diabetic-like
mice
using
a
multiomics
integrated
analysis
peptidome,
transcriptome,
and
metabolome.
Results
showed
that
the
oral
administration
CH
at
dose
600
mg/kg/day
for
4
weeks
reduced
blood
glucose
levels
by
14.73
±
9.77%,
alleviated
insulin
resistance
(HOMA-IR
index)
36.91
22.62%,
mitigated
hepatic
damage
mice.
Hepatic
differential
metabolites
after
treatment
were
enriched
Glu-related
metabolites,
which
acted
as
substrates
TCA
cycle,
enhancing
consumption.
transcriptomic
results
revealed
upregulated
(p
<
0.05)
hub
gene
expressions
pparg
pik3cb,
leading
to
an
activation
PPAR
signaling
pathway,
further
improving
insulin/PI3K/AKT
pathway.
highly
correlated
with
analysis.
Glx/Glx-containing
peptides
(Glx
represents
Glu
Gln)
CH,
dietary
supplement
increase
might
be
key
active
component
responsible
its
effect.
Particularly,
Glx
confirmed
effectively
enhance
consumption
hepatocytes.
This
provides
basis
development
CHs
functional
food.
Язык: Английский
Bioactivities, preparation, and bioavailability of food-derived proline-containing peptides
Trends in Food Science & Technology,
Год журнала:
2024,
Номер
155, С. 104776 - 104776
Опубликована: Ноя. 14, 2024
Язык: Английский
Inhibitory Effects of Gliadin Hydrolysates on BACE1 Expression and APP Processing to Prevent Aβ Aggregation
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 13212 - 13212
Опубликована: Дек. 9, 2024
Alzheimer's
disease
(AD),
a
leading
neurodegenerative
disorder,
is
closely
associated
with
the
accumulation
of
amyloid-beta
(Aβ)
peptides
in
brain.
The
enzyme
β-secretase
(BACE1),
pivotal
Aβ
production,
represents
promising
therapeutic
target
for
AD.
While
bioactive
derived
from
food
protein
hydrolysates
have
neuroprotective
properties,
their
inhibitory
effects
on
BACE1
remain
largely
unexplored.
In
this
study,
we
evaluated
potential
gliadin,
whey,
and
casein
proteins
prepared
using
bromelain,
papain,
thermolysin.
Through
vitro
cellular
assays,
bromelain-hydrolyzed
gliadin
(G-Bro)
emerged
as
most
potent
inhibitor,
an
IC
Язык: Английский
Dynamic gastrointestinal digestion of tilapia (Oreochromis mossambicus) skin gelatin: changes of hydrolysate properties and dipeptidyl peptidase IV inhibitory activity
Journal of the Science of Food and Agriculture,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Abstract
BACKGROUND
It
is
important
to
study
the
physicochemical
properties
of
tilapia
(
Oreochromis
mossambicus
)
skin
gelatin
and
changes
in
dipeptidyl
peptidase
IV
(DPP‐IV)
inhibition
activity
during
gastrointestinal
digestion
order
understand
exploit
potential
as
a
source
DPP‐IV
inhibitory
peptides.
RESULTS
The
fish‐skin
increased
from
9.92
±
0.76%
36.75
0.98%,
further
51.06
1.23%,
following
simulated
intestinal
for
period
60
min.
After
gastric
digestion,
degree
hydrolysis
(DH)
was
18.19
0.48%,
average
molecular
weight
(AMW)
219
7.19
kDa,
sum
charged
groups
−5.08
0.32,
surface
hydrophobicity
hydrolysate
24.81
0.25.
these
values
changed
27.72
0.47%,
146.56
8.16
−8.09
13.04
0.53,
respectively.
DH
exhibited
positive
correlations
with
(0.94
0.71,
respectively),
but
AMW
showed
negative
correlation
(−0.96).
MATLAB
fit
functions
were
applied
predict
theoretical
values,
fitted
equation:
=
2.5885
×
‐
0.0983
1.0047
+
3.5118.
test
set
multiple
linear
regression
model
demonstrated
an
R
2
equal
or
greater
than
0.8.
CONCLUSION
DH,
AMW,
correlated
inhibition,
equation
predicted
effectively
gelatin.
©
2024
Society
Chemical
Industry.
Язык: Английский