Dynamic gastrointestinal digestion of tilapia (Oreochromis mossambicus) skin gelatin: changes of hydrolysate properties and dipeptidyl peptidase IV inhibitory activity DOI Open Access
Ritian Jin, Chang Liu, Jing Song

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Abstract BACKGROUND It is important to study the physicochemical properties of tilapia ( Oreochromis mossambicus ) skin gelatin and changes in dipeptidyl peptidase IV (DPP‐IV) inhibition activity during gastrointestinal digestion order understand exploit potential as a source DPP‐IV inhibitory peptides. RESULTS The fish‐skin increased from 9.92 ± 0.76% 36.75 0.98%, further 51.06 1.23%, following simulated intestinal for period 60 min. After gastric digestion, degree hydrolysis (DH) was 18.19 0.48%, average molecular weight (AMW) 219 7.19 kDa, sum charged groups −5.08 0.32, surface hydrophobicity hydrolysate 24.81 0.25. these values changed 27.72 0.47%, 146.56 8.16 −8.09 13.04 0.53, respectively. DH exhibited positive correlations with (0.94 0.71, respectively), but AMW showed negative correlation (−0.96). MATLAB fit functions were applied predict theoretical values, fitted equation: = 2.5885 × ‐ 0.0983 1.0047 + 3.5118. test set multiple linear regression model demonstrated an R 2 equal or greater than 0.8. CONCLUSION DH, AMW, correlated inhibition, equation predicted effectively gelatin. © 2024 Society Chemical Industry.

Language: Английский

Exploration of the Fasting Hypoglycemic Mechanism of Casein Hydrolysate Enriched with Glu/Gln and Glu/Gln-Containing Peptides in db/db Diabetic-like Mice Using Multiomics Analysis DOI

Chenyang Wang,

Rong Xu, Chibuike C. Udenigwe

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

The fasting hypoglycemic effect of casein hydrolysate (CH) was investigated in db/db diabetic-like mice using a multiomics integrated analysis peptidome, transcriptome, and metabolome. Results showed that the oral administration CH at dose 600 mg/kg/day for 4 weeks reduced blood glucose levels by 14.73 ± 9.77%, alleviated insulin resistance (HOMA-IR index) 36.91 22.62%, mitigated hepatic damage mice. Hepatic differential metabolites after treatment were enriched Glu-related metabolites, which acted as substrates TCA cycle, enhancing consumption. transcriptomic results revealed upregulated (p < 0.05) hub gene expressions pparg pik3cb, leading to an activation PPAR signaling pathway, further improving insulin/PI3K/AKT pathway. highly correlated with analysis. Glx/Glx-containing peptides (Glx represents Glu Gln) CH, dietary supplement increase might be key active component responsible its effect. Particularly, Glx confirmed effectively enhance consumption hepatocytes. This provides basis development CHs functional food.

Language: Английский

Citations

0
Exploring anxiolytic peptides derived from walnut protein by an integrated approach of multivariate analysis, random forest methodology DOI
Zishan Hong,

Ying Cheng,

Mingjie Zhou

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106271 - 106271

Published: Feb. 1, 2025

Language: Английский

Citations

0
Preparation and Encapsulation of DPP-IV Inhibitory Peptides: Challenges and Strategies for Functional Food Development DOI Creative Commons

Rui Zhao,

Ye Zhou,

Huifang Shen

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1479 - 1479

Published: April 24, 2025

Dipeptidyl peptidase IV (DPP-IV) inhibitory peptides have emerged as promising functional ingredients for managing type 2 diabetes due to their ability enhance insulin secretion and improve glycemic control. This review provides a concise overview of current strategies the preparation encapsulation DPP-IV peptides, with focus on food industry application, evaluating bioinformatics substrate selection, methods like mild enzymatic hydrolysis, cost-effective fermentation, high-purity chemical synthesis peptide production. Challenges associated incorporating these into products are addressed, including impacts sensory properties, stability during processing digestion, need effective delivery systems bioavailability. Potential solutions targeted release, such emulsions, liposomes, nanoparticles, explored. Future research directions outlined, emphasizing necessity scalable production methods, co-encapsulation strategies, consumer acceptance studies facilitate commercialization ingredients. By addressing key areas, this aims provide theoretical foundation practical guidance development paving way broader application in prevention management diabetes.

Language: Английский

Citations

0
Bioactivities, preparation, and bioavailability of food-derived proline-containing peptides DOI
Chenyang Wang, Chibuike C. Udenigwe, Lin Zheng

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 155, P. 104776 - 104776

Published: Nov. 14, 2024

Language: Английский

Citations

2
Inhibitory Effects of Gliadin Hydrolysates on BACE1 Expression and APP Processing to Prevent Aβ Aggregation DOI Open Access
Chin‐Yu Lin,

Cheng-Hong Hsieh,

Paul B.S. Lai

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13212 - 13212

Published: Dec. 9, 2024

Alzheimer's disease (AD), a leading neurodegenerative disorder, is closely associated with the accumulation of amyloid-beta (Aβ) peptides in brain. The enzyme β-secretase (BACE1), pivotal Aβ production, represents promising therapeutic target for AD. While bioactive derived from food protein hydrolysates have neuroprotective properties, their inhibitory effects on BACE1 remain largely unexplored. In this study, we evaluated potential gliadin, whey, and casein proteins prepared using bromelain, papain, thermolysin. Through vitro cellular assays, bromelain-hydrolyzed gliadin (G-Bro) emerged as most potent inhibitor, an IC

Language: Английский

Citations

1
Dynamic gastrointestinal digestion of tilapia (Oreochromis mossambicus) skin gelatin: changes of hydrolysate properties and dipeptidyl peptidase IV inhibitory activity DOI Open Access
Ritian Jin, Chang Liu, Jing Song

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Abstract BACKGROUND It is important to study the physicochemical properties of tilapia ( Oreochromis mossambicus ) skin gelatin and changes in dipeptidyl peptidase IV (DPP‐IV) inhibition activity during gastrointestinal digestion order understand exploit potential as a source DPP‐IV inhibitory peptides. RESULTS The fish‐skin increased from 9.92 ± 0.76% 36.75 0.98%, further 51.06 1.23%, following simulated intestinal for period 60 min. After gastric digestion, degree hydrolysis (DH) was 18.19 0.48%, average molecular weight (AMW) 219 7.19 kDa, sum charged groups −5.08 0.32, surface hydrophobicity hydrolysate 24.81 0.25. these values changed 27.72 0.47%, 146.56 8.16 −8.09 13.04 0.53, respectively. DH exhibited positive correlations with (0.94 0.71, respectively), but AMW showed negative correlation (−0.96). MATLAB fit functions were applied predict theoretical values, fitted equation: = 2.5885 × ‐ 0.0983 1.0047 + 3.5118. test set multiple linear regression model demonstrated an R 2 equal or greater than 0.8. CONCLUSION DH, AMW, correlated inhibition, equation predicted effectively gelatin. © 2024 Society Chemical Industry.

Language: Английский

Citations

0