International Journal of Biological Macromolecules, Год журнала: 2024, Номер 289, С. 138676 - 138676
Опубликована: Дек. 11, 2024
Язык: Английский
Frontiers in Nutrition, Год журнала: 2025, Номер 11
Опубликована: Янв. 6, 2025
In this study, Chinese yam polysaccharides (CYPs) were fermented using Lactobacillus plantarum M616, and changes in the chemical composition, structure, anti-inflammatory activity of CYPs before after fermentation investigated. The carbohydrate content L. M616-fermented CYP (CYP-LP) increased from 71.03% ± 2.75 to 76.28% 2.37%, whereas protein polyphenol almost unaffected compared with those unfermented (CYP-NF). monosaccharide composition CYP-NF included rhamnose, arabinose, galactose, glucose, mannose a molar ratio 0.493:0.6695:0.9738:0.7655:12.4365. CYP-LP had same monosaccharides as CYP-NF, but was 0.3237:0.3457:0.8278:2.5541:10.4995. Meanwhile, molecular weight polydispersity CYP-LP, respectively, 124.774 kDa 6.58 (CYP-NF) 376.628 17.928, indicating low homogeneity. vitro antioxidant analysis showed that M616 varying effects on against DPPH, ABTS, hydroxyl, superoxide radicals. However, superior is more effective regulating dismutase, catalase, glutathione peroxidase, malondialdehyde, nitric oxide, tumor necrosis factor-α, interleukin-1β, interleukin-6 release lipopolysaccharide-induced RAW 264.7 macrophages. This study suggested potential ingredient drugs functional food.
Язык: Английский
Процитировано
2
Biology, Год журнала: 2025, Номер 14(1), С. 87 - 87
Опубликована: Янв. 17, 2025
Oxidative stress, a critical factor affecting the health and productivity of aquatic organisms, arises from imbalance between reactive oxygen species (ROS) production antioxidant defenses. In aquaculture, natural antioxidants have gained increasing attention as sustainable feed additives to mitigate oxidative damage, enhance immune responses, improve overall growth performance. This review provides comprehensive synthesis antioxidative mechanisms key antioxidants, including carotenoids, polysaccharides, vitamins, polyphenols, flavonoids. By neutralizing ROS modulating cellular signaling pathways such Nrf2/ARE, these compounds offer significant protective effects against damage in species. The manuscript consolidates recent advancements research, highlighting their practical applications formulation role promoting sustainability aquaculture. aims provide an integrative framework for understanding antioxidants’ potential, guiding future research implementation aquaculture systems.
Язык: Английский
Процитировано
2
Innovative Food Science & Emerging Technologies, Год журнала: 2024, Номер 98, С. 103863 - 103863
Опубликована: Ноя. 4, 2024
Язык: Английский
Процитировано
11
Foods, Год журнала: 2025, Номер 14(4), С. 564 - 564
Опубликована: Фев. 8, 2025
In this study, Chinese yam polysaccharide (CYP) was fermented by Saccharomyces cerevisiae CICC 32883, and its structural features antioxidant activities before after fermentation were analyzed. S. 32883-fermented CYP (CYP-SC) had higher carbohydrate content lower protein than the nonfermented (CYP-NF). The monosaccharide composition of CYP-SC unaffected, but proportion changed. Compared with CYP-NF's molecular weight polydispersity 124.774 kDa 6.58, respectively, those reduced to 20.384 3.379. Antioxidant results showed that better effects CYP-NF in scavenging DPPH, ABTS, hydroxyl, superoxide radicals. Moreover, enhancing oxidation capacity protecting HepG2 cells CYP-NF. Furthermore, on alleviating repairing H2O2-damaged are superior This work offers a green efficient method for activity dietary plant polysaccharides.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142134 - 142134
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Marine Drugs, Год журнала: 2024, Номер 22(8), С. 356 - 356
Опубликована: Авг. 2, 2024
Chlamydomonas reinhardtii polysaccharides (CRPs) are bioactive compounds derived from C. reinhardtii, yet their potential in cancer therapy remains largely unexplored. This study optimized the ultrasound-assisted extraction conditions using response surface methodology and proceeded with isolation purification of these polysaccharides. The optimal were identified as a sodium hydroxide concentration 1.5%, ultrasonic power 200 W, solid-to-liquid ratio 1:25 g/mL, an treatment time 10 min, water bath duration 2.5 h, yielding actual rate 5.71 ± 0.001%, which closely aligns predicted value 5.639%. Infrared analysis revealed that CRP-1 CRP-2 α-pyranose structures containing furoic acid, while CRP-3 CRP-4 β-pyranose acid. Experimental results demonstrated all four purified inhibited proliferation cervical (HeLa) hepatoma (HepG-2) colon (HCT-116) cells, showing most significant inhibitory effect on cancer, achieving inhibition rates 60.58 0.88% 40.44 1.44%, respectively, significantly reducing migration HeLa cells. DAPI staining confirmed inhibit cell by inducing apoptosis has liver not only elucidates application but also provides scientific basis for further development utilization.
Язык: Английский
Процитировано
4
Preparative Biochemistry & Biotechnology, Год журнала: 2025, Номер unknown, С. 1 - 10
Опубликована: Фев. 18, 2025
Due to the restricts of treatment methods and high costs, waste tobacco materials are usually discarded, which leads resources environmental pollution. Present work used leaves as carbon source produce polysaccharide (CGP-TL) by Chaetomium globosum CGMCC 6882 via submerged fermentation. CGP-TL yield was 1.62 ± 0.35 g/L, contents carbohydrate protein in were 91.73% 6.49% 5.51% 0.84%. Structural characterization showed composed rhamnose, arabinose, galactose, glucose, mannose xylose a molar ratio 9.9688: 6.8482: 19.6045: 29.4448: 0.8033: 0.5874. Meanwhile, its weight-average molecular weight, number-average weight polydispersity 286.035 kDa, 118.146 kDa 2.421, respectively. In vitro antioxidant analysis scavenged DPPH, ABTS, hydroxyl superoxide radicals positively correlated concentration, corresponding scavenging effects at 2.5 mg/mL 75.53% 1.89%, 96.24% 2.32%, 52.91% 2.28% 65.26% 2.47%. Furthermore, not only improved antioxidative status RAW 264.7 cells, but also exerted oxidative repairing on H2O2-damaged cells increasing levels SOD, CAT GSH-Px, reducing MDA level. Overall, this will provide references for green efficient utilization cellulose resources.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142177 - 142177
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 27, 2025
Liver diseases are a serious health problem worldwide, especially with sustained increase in the burden of it every year. However, drugs commonly used patients have limited efficacy and adverse reactions associated long-term use. Therefore, is urgent to find effective safe alternatives. Polysaccharides currently considered promising alternatives traditional because their extensive activity low toxicity. This review investigated studies on hepatoprotective polysaccharides over past 6 years, detailing effects, potential mechanisms, drug carrier applications. These findings suggest that prominent preventive therapeutic effects various liver such as drug-induced injury, alcoholic disease, hepatitis B, non-alcoholic fatty fibrosis, hepatocellular carcinoma. Its mechanism includes multiple aspects metabolic regulation, reduction oxidative stress inflammation, regulation gut microbiota. Furthermore, owing good physicochemical properties, been applied delivery systems for chemotherapy small molecule drugs. further research essential bioavailability, structure-activity relationship, more clinical evidence polysaccharides. Continued exploration will provide tremendous treatment diseases.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 137007 - 137007
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
3