2′-FL in Dairy Matrices Attenuates Allergic Symptoms in Mice by Reducing BLG Hypersensitivity and Modulating Gut Microecology DOI

Xintong Chen,

Fan Yang,

Tianliang Bai

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

2'-Fucosyllactose (2'-FL), an industrial breast milk oligosaccharide, is approved for use in infant formula and may reduce cow's protein allergenicity. To investigate whether glycosylation products of 2'-FL dairy (2'-FL-β-LG) increase its sensitization, we cross-linked β-LG with used it to sensitize Balb/c mice, comparing nonglycosylated β-LG. Both 2'-FL-β-LG sensitization oral intervention reduced allergic symptoms, specific antibodies (IgE, IgG, IgG2a), inflammatory cytokine levels, intestinal damage. also shifted T-cell differentiation, cell surface expression DC receptors, enhanced gut microbial diversity. Oral showed the greatest efficacy, suggesting potential lowering allergenicity formula.

Язык: Английский

Pea protein sensitization: insights from allergy model experiment in BALB/c mice DOI
Peipei Li, Yongli Ye, Jian Ji

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106357 - 106357

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
2′-FL in Dairy Matrices Attenuates Allergic Symptoms in Mice by Reducing BLG Hypersensitivity and Modulating Gut Microecology DOI

Xintong Chen,

Fan Yang,

Tianliang Bai

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

2'-Fucosyllactose (2'-FL), an industrial breast milk oligosaccharide, is approved for use in infant formula and may reduce cow's protein allergenicity. To investigate whether glycosylation products of 2'-FL dairy (2'-FL-β-LG) increase its sensitization, we cross-linked β-LG with used it to sensitize Balb/c mice, comparing nonglycosylated β-LG. Both 2'-FL-β-LG sensitization oral intervention reduced allergic symptoms, specific antibodies (IgE, IgG, IgG2a), inflammatory cytokine levels, intestinal damage. also shifted T-cell differentiation, cell surface expression DC receptors, enhanced gut microbial diversity. Oral showed the greatest efficacy, suggesting potential lowering allergenicity formula.

Язык: Английский

Процитировано

0