Association of blood cadmium, lead, and mercury with anxiety: a cross-sectional study from NHANES 2007–2012

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Авг. 12, 2024

Objectives The purpose of this paper is to explore the relationship between blood levels cadmium, lead, and mercury anxiety in American adults. Methods Blood metals self-reported days were extracted from laboratory data questionnaire data, respectively, using NHANES 2007–2012. Weighted logistic regression was used assess lead with anxiety. Restricted cubic spline visualize non-linear metal concentrations quantile sum (WQS) investigate effect combined exposure three on Results prevalence adults 26.0%. After adjusting for potential confounding variables, cadmium highest quartile (Q4) associated a higher risk compared lowest (Q1) (OR = 1.279, 95% CI: 1.113–1.471, p < 0.01). analysis indicated positive association Furthermore, co-exposure multiple heavy positively (WQS positive: OR 1.068, 1.016–1.160, 0.05), contributing most overall mixture effect. Compared Light RPA, Vigorous/Moderate RPA group had relatively low after exposure. Conclusion High are development disorders, which needs be further verified future studies.

Язык: Английский

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Effects of alkaline mineral complex water supplementation on growth performance, inflammatory response, and intestinal barrier function in weaned piglets

Journal of Animal Science, Год журнала: 2022, Номер 100(10)

Опубликована: Авг. 1, 2022

The purpose of the present study was to investigate effects drinking water alkaline mineral complex (AMC) supplementation on growth performance, intestinal morphology, inflammatory response, immunity, antioxidant defense system, and barrier functions in weaned piglets. In a 15-d trial, 240 piglets (9.35 ± 0.86 kg) at 28 d age (large white × landrace Duroc) were randomly divided into two groups: control (Con) group AMC group. Drinking improved (P < 0.01) final body weight (BW) average daily gain (ADG) compared Con Importantly, reduced feed-to-gain (F:G) ratio. physical health conditions under weaning stress, as reflected by decreased 0.05) hair score conjunctival score. Moreover, there no significant > difference relatively small length, organ (liver, spleen, kidney) indices, or gastrointestinal pH value between groups. Of note, significantly promoted microvilli numbers intestine effectively ameliorated gut morphology damage induced evidenced increased villous height (VH) ratio VH crypt depth. Additionally, lessened levels lipopolysaccharide (LPS, P contents IL1β (P<0.05), TNF-α (P<0.05) piglet intestine. Conversely, immune marker, secretory immunoglobulin A (sIgA) serum mucosa elevated after treatment 0.01). Furthermore, mRNA SOD 1-2, CAT, GPX 1-2 Likewise, tight junction factors Occludin 0.01), ZO-1 0.05), Claudin 2 5 (P<0.01) notably higher than those conclusion, has an accelerative effect performance elevating improving function piglets.The suffers vital physiological, environmental, social challenges when it is from sow that can predispose subsequent diseases other production losses, these are responsible for serious economic losses swine industry. Weaning stress induces injury, digestive system dysfunction, which then reduces feed intake inhibits It well known alternatives antibiotics preventing farm animals sorely needed. biologically beneficial widely reported. Alkaline (AMC), immunomodulator, considered have antistress addition, through be efficient low-cost feasible disease strategy. expected exert benefits pigs; however, responses supplemented with not been fully explored. Thus, this explored Our results showed conspicuously enhanced health.

Язык: Английский

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Metallomic and Untargeted Metabolomic Signatures of Human Milk from SARS‐CoV‐2 Positive Mothers

Molecular Nutrition & Food Research, Год журнала: 2022, Номер 66(16)

Опубликована: Июнь 10, 2022

Lack of information about the impact maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on elemental and metabolomic profile human milk (HM).An observational study HM from mothers with COVID-19 is conducted including a prepandemic control group. Maternal-infant clinical records symptomatology are recorded. The absolute quantification elements untargeted relative profiles determined by inductively coupled plasma mass spectrometry gas chromatography to spectrometry, respectively. Associations SARS-CoV-2 antibodies studied. has significant composition. reduces concentrations Fe, Cu, Se, Ni, V, Aluminium (Al) increases Zn compared samples. A total 18 individual metabolites amino acids, peptides, fatty acids conjugates, purines derivatives, alcohols, polyols significantly different in positive mothers. Aminoacyl-tRNA biosynthesis, phenylalanine, tyrosine tryptophan linoleic acid pathways altered. Differences obtained depending symptomatic asymptomatic status.This provides unique insights that warrants further research due potential implications for infant health.

Язык: Английский

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Association between trace metals exposure and hearing loss

Frontiers in Public Health, Год журнала: 2022, Номер 10

Опубликована: Авг. 17, 2022

Trace metals have side-effect on human health. The association between trace exposure and hearing loss remains unclear.A total of 8,128 participants were exacted for analysis from the database National Health Nutrition Examination Survey (NHANES) (2013-2018). Multivariable logistic regression restricted cubic spline models used to examine loss.Participants with had a higher level lead, cadmium, molybdenum, tin, thallium, tungsten (all p < 0.05). After adjusting confounders, compared reference lowest quartile, ORs 95%CIs across quartiles 1.14 (0.86, 1.51), 1.49 (1.12, 1.98), 1.32 (0.97, 1.80) cobalt, 1.35 (0.98, 1.87), 1.58 (1.15, 2.16), 1.75 (1.28, 2.40) tin. Individuals cobalt at third quartile 49% risks than those quartile. And highest tin 1.75-folds There increasing trends in raised thallium (p trend <0.05). Restricted indicated that there was nonlinear levels nonlinearity = 0.021). Subgroup showed individuals female, without hypertension diabetes, low-density lipoprotein cholesterol modified effects associations tin.Our study significantly associated loss.

Язык: Английский

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The close association of micronutrients with COVID-19

Heliyon, Год журнала: 2024, Номер 10(7), С. e28629 - e28629

Опубликована: Март 27, 2024

ObjectivesThe present study was conducted to explore the performance of micronutrients in prediction and prevention coronavirus disease 2019 (COVID-19).MethodsThis is an observational case-control study. 149 normal controls (NCs) 214 COVID-19 patients were included this Fat-soluble water-soluble vitamins determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, inorganic elements detected inductively coupled plasma-mass (ICP-MS) analysis. A logistic regression model based on six constructed using DxAI platform.ResultsMany dysregulated compared control (NC). 25-Hydroxyvitamin D3 [25(OH)D3], magnesium (Mg), copper (Cu), calcium (Ca) vitamin B6 (pyridoxic acid, PA) significantly independent risk factors for COVID-19. The consisted 25(OH)D3, Mg, Cu, Ca, B5 (VB5) PA developed, displayed a strong discriminative capability differentiate from NC individuals [area under receiver operating characteristic curve (AUROC) = 0.901]. In addition, had great predictive ability discriminating mild/normal (AUROC 0.883).ConclusionsOur showed that associated with COVID-19, our has potential clinical management will be useful screening high-risk population.

Язык: Английский

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