Metallomic and Untargeted Metabolomic Signatures of Human Milk from SARS‐CoV‐2 Positive Mothers

Molecular Nutrition & Food Research, Journal Year: 2022, Volume and Issue: 66(16)

Published: June 10, 2022

Lack of information about the impact maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on elemental and metabolomic profile human milk (HM).An observational study HM from mothers with COVID-19 is conducted including a prepandemic control group. Maternal-infant clinical records symptomatology are recorded. The absolute quantification elements untargeted relative profiles determined by inductively coupled plasma mass spectrometry gas chromatography to spectrometry, respectively. Associations SARS-CoV-2 antibodies studied. has significant composition. reduces concentrations Fe, Cu, Se, Ni, V, Aluminium (Al) increases Zn compared samples. A total 18 individual metabolites amino acids, peptides, fatty acids conjugates, purines derivatives, alcohols, polyols significantly different in positive mothers. Aminoacyl-tRNA biosynthesis, phenylalanine, tyrosine tryptophan linoleic acid pathways altered. Differences obtained depending symptomatic asymptomatic status.This provides unique insights that warrants further research due potential implications for infant health.

Language: Английский

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Association between trace metals exposure and hearing loss

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Aug. 17, 2022

Trace metals have side-effect on human health. The association between trace exposure and hearing loss remains unclear.A total of 8,128 participants were exacted for analysis from the database National Health Nutrition Examination Survey (NHANES) (2013-2018). Multivariable logistic regression restricted cubic spline models used to examine loss.Participants with had a higher level lead, cadmium, molybdenum, tin, thallium, tungsten (all p < 0.05). After adjusting confounders, compared reference lowest quartile, ORs 95%CIs across quartiles 1.14 (0.86, 1.51), 1.49 (1.12, 1.98), 1.32 (0.97, 1.80) cobalt, 1.35 (0.98, 1.87), 1.58 (1.15, 2.16), 1.75 (1.28, 2.40) tin. Individuals cobalt at third quartile 49% risks than those quartile. And highest tin 1.75-folds There increasing trends in raised thallium (p trend <0.05). Restricted indicated that there was nonlinear levels nonlinearity = 0.021). Subgroup showed individuals female, without hypertension diabetes, low-density lipoprotein cholesterol modified effects associations tin.Our study significantly associated loss.

Language: Английский

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The close association of micronutrients with COVID-19

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28629 - e28629

Published: March 27, 2024

ObjectivesThe present study was conducted to explore the performance of micronutrients in prediction and prevention coronavirus disease 2019 (COVID-19).MethodsThis is an observational case-control study. 149 normal controls (NCs) 214 COVID-19 patients were included this Fat-soluble water-soluble vitamins determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, inorganic elements detected inductively coupled plasma-mass (ICP-MS) analysis. A logistic regression model based on six constructed using DxAI platform.ResultsMany dysregulated compared control (NC). 25-Hydroxyvitamin D3 [25(OH)D3], magnesium (Mg), copper (Cu), calcium (Ca) vitamin B6 (pyridoxic acid, PA) significantly independent risk factors for COVID-19. The consisted 25(OH)D3, Mg, Cu, Ca, B5 (VB5) PA developed, displayed a strong discriminative capability differentiate from NC individuals [area under receiver operating characteristic curve (AUROC) = 0.901]. In addition, had great predictive ability discriminating mild/normal (AUROC 0.883).ConclusionsOur showed that associated with COVID-19, our has potential clinical management will be useful screening high-risk population.

Language: Английский

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Rare Earth and Platinum Group Elements In Sub-Saharan Africa and Global Health: The Dark Side of the Burgeoning of Technology

Environmental Health Insights, Journal Year: 2024, Volume and Issue: 18

Published: Jan. 1, 2024

Despite steady progress in the development and promotion of circular economy as a model, an overwhelming proportion technological devices discarded by Global North still finds its way to South, where technology-related environmental health problems start from predation resources continue all recycling disposal. We reviewed literature on TCEs sub-Saharan Africa (SSA), focussing on: sources levels pollution; extent human exposure these substances; their role aetiology diseases; effects environment. Our review shows that even minor often neglected technology-critical elements (TCEs), like rare earth (REEs) platinum group (PGEs), reveal damage detrimental caused massive mining raw materials, exacerbated improper disposal e-waste (from dumping open burning). draw attention local research knowledge gaps such workable safer methods for TCE recovery end-of-life products, secondary materials e-waste, bioremediation detoxification. The technical political shortcomings management SSA is more alarming against background unfavourable determinants resulting higher susceptibility diseases, especially among children who work mines sites or reside sites.This paper demonstrates, first time, unjust North-South dynamics evident trace premise underlying attempts solve problem dumped through technology fact misleading. influx foreign electrical electronic equipments should be controlled limited clearly defining what 'useful' second-hand device e-waste; risks arising components processing by-products managed differently, scientific uncertainty One Health thinking incorporated risk assessment.

Language: Английский

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Metallomic analysis of urine from individuals with and without Covid-19 infection reveals extensive alterations in metal homeostasis

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127557 - 127557

Published: Oct. 30, 2024

Language: Английский

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