Effects of T-2 toxin on growth performance, feather quality, tibia development and blood parameters in Yangzhou goslings DOI Creative Commons
Wang Gu, Qiang Bao, Kaiqi Weng

и другие.

Poultry Science, Год журнала: 2022, Номер 102(2), С. 102382 - 102382

Опубликована: Дек. 6, 2022

T-2 toxin is a dangerous natural pollutant and widely exists in animal feed, often causing toxic damage to poultry, such as slow growth development, immunosuppression, death. Although geese are considered the most sensitive poultry toxin, exact caused by elusive. In present study, total of forty two 1-day-old healthy Yangzhou male goslings were randomly allotted seven diets contaminated with 0, 0.2, 0.4, 0.6, 0.8, 1.0, or 2.0 mg/kg for 21 d, effects exposure on performance, feather quality, tibia blood parameters investigated. The results showed that significantly inhibited feed intake, body weight gain, shank length growth, organ development (e.g., ileum, cecum, liver, spleen, bursa, tibia) dose-dependent manner. addition, more serious feathering abnormalities observed exposed high dose (0.8, mg/kg), which mainly sparsely covered short, dry, rough, curly, gloss-free feathers back. We also found hypertrophic chondrocytes tibial plate exhibited abnormal morphology nuclear consolidation loss, accompanied necrosis excessive apoptosis under exposure. Moreover, triggered erythropenia, thrombocytosis, alanine aminotransferase, aspartate aminotransferase activity, well urea nitrogen, uric acid, lactic dehydrogenase levels. Collectively, these data indicate had an adverse effect liver kidney goslings, providing crucial information toward prevention control contamination feed.

Язык: Английский

T-2 toxin triggers lipid metabolism disorder and oxidative stress in liver of ducks DOI Creative Commons

Keying An,

Bozhi Shi,

Xueze Lv

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 286, С. 117169 - 117169

Опубликована: Окт. 12, 2024

Язык: Английский

Процитировано

3
T-2 toxin-induced splenic injury by disrupting the gut microbiota–spleen axis via promoting IL-6/JAK/STAT1 signaling-mediated inflammation and apoptosis and its mitigation by elemental nano-selenium DOI
Meng Liu, Xuewu Li, Hua Sun

и другие.

Archives of Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Язык: Английский

Процитировано

0
p38 mediates T-2 toxin-induced Leydig cell testosterone synthesis disorder DOI Creative Commons
Xu Yang,

Wenxi Song,

Kefei Zhang

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 253, С. 114695 - 114695

Опубликована: Фев. 27, 2023

T-2 toxin is an unavoidable food and feed contaminant that seriously threatens human animal health. Exposure to can cause testosterone synthesis disorder in male animals, but the molecular mechanism still not completely clear. The MAPK pathway participates regulation of by Leydig cells, it unclear whether toxin-induced disorders. In this research, capacity, synthase expression activation were examined mice TM3 cells exposed toxin. results showed exposure decreased testicular volume caused pathological changes microstructure ultrastructure cells. also content protein synthase. vitro, inhibited cell viability contents culture supernatants. Moreover, activated increasing p38, JNK ERK as well p-p38, p-JNK p-ERK testis p38 inhibitor (SB203580) significantly alleviated decrease reduction summary, mediates disorder.

Язык: Английский

Процитировано

8
A review of anorexia induced by T-2 toxin DOI

Ting-Yu Huang,

Wenxi Song,

Y. Wang

и другие.

Food and Chemical Toxicology, Год журнала: 2023, Номер 179, С. 113982 - 113982

Опубликована: Авг. 6, 2023

Язык: Английский

Процитировано

8
Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review DOI Creative Commons
Pengju Wang, Lv‐Hui Sun,

Xu Wang

и другие.

Animal nutrition, Год журнала: 2023, Номер 16, С. 251 - 266

Опубликована: Дек. 4, 2023

T-2 toxin is one of the most widespread and toxic fungal toxins in food feed. It can cause gastrointestinal toxicity, hepatotoxicity, immunotoxicity, reproductive neurotoxicity, nephrotoxicity humans animals. physicochemically stable does not readily degrade during feed processing. Therefore, suppressing toxin-induced organ toxicity through antidotes an urgent issue. Protective agents against have been recorded widely literature, but these protective their molecular mechanisms detoxification comprehensively summarized. In this review, we provide overview various to underlying effects. Targeting appropriate targets antagonize also important option. This review will essential guidance strategies for better application development specific future.

Язык: Английский

Процитировано

8
Inflammation-related pathways involved in damaged articular cartilage of rats exposed to T-2 toxin based on RNA-sequencing analysis DOI Creative Commons

Longyan Shi,

Qiuliang Liu,

Heying Yang

и другие.

Frontiers in Genetics, Год журнала: 2022, Номер 13

Опубликована: Дек. 5, 2022

Many studies have shown that ingestion of the T-2 toxin is harmful to articular cartilage. However, mechanisms underlying damaged cartilage induced by not been elucidated. Twenty-four SD rats were randomly divided into and control groups. In group, 12 administered 4% absolute ethanol gavage, in (100 ng/g, BW/day) gavage. After sacrificed, knee joints collected, RNA was extracted using TRIzol reagent for sequencing (RNA-seq). Differentially expressed mRNA identified based on p < 0.05 | log2 (fold change) > 1. The toxin-related genes obtained from GeneCards database. An online tool (https://www.bioinformatics.com.cn) used enrichment analysis. Hematoxylin eosin (H&E) staining observe cartilage, immunohistochemical (IHC) validate differentially proteins. H&E shows number cells decreased significantly, arrangement chondrocytes became disordered group. RNA-seq analysis 195 upregulated 89 downregulated mRNAs top immune-related biological processes (Gene Ontology) regulation hormone secretion, peptide transcription involved cell fate commitment. KEGG pathway revealed IL-17 tumor necrosis factor signaling pathways significantly expressed, also genes. Also, Mmp3, Tnf, Mapk10, Ccl11, Creb5, Cxcl2, Cebpb enriched two pathways. showed levels Mmp3 Tnf proteins increased which consistent with results. This study critical roles TNF toxin.

Язык: Английский

Процитировано

11
The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms DOI Creative Commons
Chengshui Liao,

Fengru Xu,

Zuhua Yu

и другие.

Veterinary Sciences, Год журнала: 2024, Номер 11(7), С. 291 - 291

Опубликована: Июнь 28, 2024

Mycotoxins are secondary metabolites produced by several fungi and moulds that exert toxicological effects on animals including immunotoxicity, genotoxicity, hepatotoxicity, teratogenicity, neurotoxicity. However, the mechanisms of mycotoxins complex unclear. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin containing 3 (NLRP3) inflammasome is a multimeric cytosolic protein composed NLRP3 sensor, ASC adapter protein, caspase-1 effector. Activation plays crucial role in innate immune defence homeostatic maintenance. Recent studies have revealed activation linked to tissue damage inflammation induced mycotoxin exposure. Thus, this review summarises latest advancements research roles pathogenesis exposure multiple mycotoxins, deoxynivalenol, aflatoxin B1, zearalenone, T-2 toxin, ochratoxin A, fumonisim pyroptosis-related factors inflammation-related vitro vivo pharmacological inhibition specific nonspecific inhibitors summarized examined. This comprehensive contributes better understanding toxicity provides novel insights for pharmacologically targeting as anti-inflammatory agent against

Язык: Английский

Процитировано

2
Inhibition of Macrophage Pyroptosis─A New Therapeutic Strategy to Alleviate T-2 Toxin-Induced Subacute Liver Injury by Directly Competing with the Key Target DOI
Xiaoqing Xu, Yue Wu,

Yongxia Zhao

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(33), С. 18670 - 18681

Опубликована: Авг. 7, 2024

Multiple compounds are related to the development of liver injury, such as toxins, drugs, and environmental pollutants. Although there reports that T-2 toxin can cause its toxic mechanism remains unclear, which further impedes effective antidotes. In this study, CRISPR-Cas9 genome-wide screening technology was used identify transformation-related protein 53 inducible nuclear 1 (trp53inp1) a target toxin. Mechanism studies have shown induced pyroptosis macrophages (J774A.1 cells) by activating trp53inp1/NF-κB/NLRP3/GSDMD-N pathway, leading subacute injury. Also, new drug berberine (BER) identified through virtual significantly alleviated injury competitively binding trp53inp1 via His224; effect better than those positive control drugs N-acetylcysteine (NAC) disulfiram (DSF). summary, above results indicate is key for induce inhibiting macrophage method treating addition, study provides strategy discovery disease targets search drugs.

Язык: Английский

Процитировано

2
Sodium butyrate alleviates T‐2 toxin–induced liver toxicity and renal toxicity in quails by modulating oxidative stress–related Nrf2 signaling pathway, inflammation, and CYP450 enzyme system DOI
Yihao He,

Xueyan Zhu,

Huanni Song

и другие.

Journal of Food Science, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Abstract T‐2 toxin is a member of class A aspergilloides toxins, one the most prevalent mycotoxins that contaminate feed and food. Direct ingestion animals or contaminated by can cause various animal diseases. Butyrate an organic fatty acid featuring four‐carbon chain, which commonly found in form sodium butyrate (NaB). NaB has several biological functions pharmacological effects. However, role alleviating toxin–induced hepatorenal toxicity not been explored. In this study, 240 juvenile quails were evenly assigned into 4 groups. The experimental setup comprised four groups: control group received standard diet; diet containing 0.9 mg/kg toxin; 0.5 g/kg NaB; treatment both NaB. We evaluated histopathological changes kidney liver on Days 14 28 explored molecular mechanisms involving oxidative stress, inflammation, expression nuclear xenobiotic receptors (NXRs). Our results showed exposure–induced inflammation activating stress pathway modulating NXRs to regulate related CYP450 isoforms, ultimately leading injury kidney, whereas ameliorated injury. These offer novel insights underlying protective effects mitigating quails. Practical Application have well described animals, but studies birds are limited. With development society, market scale farming expanding, value meat eggs increasing; there urgent need clarify harm its mechanism.

Язык: Английский

Процитировано

2
Unraveling the Nrf2-ARE Signaling Pathway in the DF-1 Chicken Fibroblast Cell Line: Insights into T-2 Toxin-Induced Oxidative Stress Regulation DOI Creative Commons

Suisui Gao,

Kaixin Wang,

Kuan-Kuan Xiong

и другие.

Toxins, Год журнала: 2023, Номер 15(11), С. 627 - 627

Опубликована: Окт. 25, 2023

The T-2 toxin (T2) poses a major threat to the health and productivity of animals. present study aimed investigate regulatory mechanism Nrf2 derived from broilers against T2-induced oxidative damage. DF-1 cells, including those with normal characteristics, as well overexpressing or knockout specific components, were exposed 24 h treatment 50 nM T2. primary objective was evaluate indicators associated stress expression downstream antioxidant factors regulated by Nrf2-ARE signaling pathway, at both mRNA protein levels. findings this demonstrated noteworthy relationship between up-regulation considerable reduction in levels within cells (p < 0.05). Furthermore, notable increase pathway Conversely, down-regulation linked marked elevation Additionally, resulted significant decrease This experiment lays theoretical foundation for investigating detrimental impacts T2 on broiler chickens. It also establishes research framework employing chicken production breeding. Moreover, it introduces novel insights prospective management stress-related ailments livestock poultry industry.

Язык: Английский

Процитировано

4