Effects of T-2 toxin on growth performance, feather quality, tibia development and blood parameters in Yangzhou goslings DOI Creative Commons
Wang Gu, Qiang Bao, Kaiqi Weng

et al.

Poultry Science, Journal Year: 2022, Volume and Issue: 102(2), P. 102382 - 102382

Published: Dec. 6, 2022

T-2 toxin is a dangerous natural pollutant and widely exists in animal feed, often causing toxic damage to poultry, such as slow growth development, immunosuppression, death. Although geese are considered the most sensitive poultry toxin, exact caused by elusive. In present study, total of forty two 1-day-old healthy Yangzhou male goslings were randomly allotted seven diets contaminated with 0, 0.2, 0.4, 0.6, 0.8, 1.0, or 2.0 mg/kg for 21 d, effects exposure on performance, feather quality, tibia blood parameters investigated. The results showed that significantly inhibited feed intake, body weight gain, shank length growth, organ development (e.g., ileum, cecum, liver, spleen, bursa, tibia) dose-dependent manner. addition, more serious feathering abnormalities observed exposed high dose (0.8, mg/kg), which mainly sparsely covered short, dry, rough, curly, gloss-free feathers back. We also found hypertrophic chondrocytes tibial plate exhibited abnormal morphology nuclear consolidation loss, accompanied necrosis excessive apoptosis under exposure. Moreover, triggered erythropenia, thrombocytosis, alanine aminotransferase, aspartate aminotransferase activity, well urea nitrogen, uric acid, lactic dehydrogenase levels. Collectively, these data indicate had an adverse effect liver kidney goslings, providing crucial information toward prevention control contamination feed.

Language: Английский

A review of anorexia induced by T-2 toxin DOI

Ting-Yu Huang,

Wenxi Song,

Y. Wang

et al.

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 179, P. 113982 - 113982

Published: Aug. 6, 2023

Language: Английский

Citations

7
Chondrocyte autophagy mediated by T-2 toxin via AKT/TSC/Rheb/mTOR signaling pathway and protective effect of CSA-SeNP DOI
Xue Lin, Haobiao Liu, Lichun Qiao

et al.

Osteoarthritis and Cartilage, Journal Year: 2024, Volume and Issue: 32(10), P. 1283 - 1294

Published: May 28, 2024

Language: Английский

Citations

2
The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms DOI Creative Commons
Chengshui Liao,

Fengru Xu,

Zuhua Yu

et al.

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(7), P. 291 - 291

Published: June 28, 2024

Mycotoxins are secondary metabolites produced by several fungi and moulds that exert toxicological effects on animals including immunotoxicity, genotoxicity, hepatotoxicity, teratogenicity, neurotoxicity. However, the mechanisms of mycotoxins complex unclear. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin containing 3 (NLRP3) inflammasome is a multimeric cytosolic protein composed NLRP3 sensor, ASC adapter protein, caspase-1 effector. Activation plays crucial role in innate immune defence homeostatic maintenance. Recent studies have revealed activation linked to tissue damage inflammation induced mycotoxin exposure. Thus, this review summarises latest advancements research roles pathogenesis exposure multiple mycotoxins, deoxynivalenol, aflatoxin B1, zearalenone, T-2 toxin, ochratoxin A, fumonisim pyroptosis-related factors inflammation-related vitro vivo pharmacological inhibition specific nonspecific inhibitors summarized examined. This comprehensive contributes better understanding toxicity provides novel insights for pharmacologically targeting as anti-inflammatory agent against

Language: Английский

Citations

2
Resveratrol Alleviated T‐2 Toxin‐Induced Liver Injury via Preservation of Nrf2 Pathway and GSH Synthesis DOI
Hong Jin, Jun He, Min Wu

et al.

Environmental Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

ABSTRACT T‐2 toxin is a trichothecene mycotoxin and considered as an extremely inevitable pollutant with potent hepatotoxicity. However, the approach to alleviation of toxin‐triggered hepatotoxicity has been recognized serious challenge. Resveratrol (Res) polyphenol natural product isolated from various plant species, but its protective effect against detailed mechanism remains obscure. In present study, Res was evaluated, underlying mechanisms were further revealed in mice. Functionally, inhibited liver injury, oxidative damage, mitochondrial dysfunction induced by toxin. Mechanistically, modulated Nrf2‐mediated antioxidant pathway glutathione synthesis inhibition. Collectively, our findings first showed beyond doubt that ameliorated injury regulating Nrf2 pathways

Language: Английский

Citations

2
Sodium butyrate alleviates T‐2 toxin–induced liver toxicity and renal toxicity in quails by modulating oxidative stress–related Nrf2 signaling pathway, inflammation, and CYP450 enzyme system DOI
Yihao He,

Xueyan Zhu,

Huanni Song

et al.

Journal of Food Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract T‐2 toxin is a member of class A aspergilloides toxins, one the most prevalent mycotoxins that contaminate feed and food. Direct ingestion animals or contaminated by can cause various animal diseases. Butyrate an organic fatty acid featuring four‐carbon chain, which commonly found in form sodium butyrate (NaB). NaB has several biological functions pharmacological effects. However, role alleviating toxin–induced hepatorenal toxicity not been explored. In this study, 240 juvenile quails were evenly assigned into 4 groups. The experimental setup comprised four groups: control group received standard diet; diet containing 0.9 mg/kg toxin; 0.5 g/kg NaB; treatment both NaB. We evaluated histopathological changes kidney liver on Days 14 28 explored molecular mechanisms involving oxidative stress, inflammation, expression nuclear xenobiotic receptors (NXRs). Our results showed exposure–induced inflammation activating stress pathway modulating NXRs to regulate related CYP450 isoforms, ultimately leading injury kidney, whereas ameliorated injury. These offer novel insights underlying protective effects mitigating quails. Practical Application have well described animals, but studies birds are limited. With development society, market scale farming expanding, value meat eggs increasing; there urgent need clarify harm its mechanism.

Language: Английский

Citations

2
T-2 toxin triggers lipid metabolism disorder and oxidative stress in liver of ducks DOI Creative Commons

Keying An,

Bozhi Shi,

Xueze Lv

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117169 - 117169

Published: Oct. 12, 2024

Language: Английский

Citations

2
Inflammation-related pathways involved in damaged articular cartilage of rats exposed to T-2 toxin based on RNA-sequencing analysis DOI Creative Commons

Longyan Shi,

Qiuliang Liu,

Heying Yang

et al.

Frontiers in Genetics, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 5, 2022

Many studies have shown that ingestion of the T-2 toxin is harmful to articular cartilage. However, mechanisms underlying damaged cartilage induced by not been elucidated. Twenty-four SD rats were randomly divided into and control groups. In group, 12 administered 4% absolute ethanol gavage, in (100 ng/g, BW/day) gavage. After sacrificed, knee joints collected, RNA was extracted using TRIzol reagent for sequencing (RNA-seq). Differentially expressed mRNA identified based on p < 0.05 | log2 (fold change) > 1. The toxin-related genes obtained from GeneCards database. An online tool (https://www.bioinformatics.com.cn) used enrichment analysis. Hematoxylin eosin (H&E) staining observe cartilage, immunohistochemical (IHC) validate differentially proteins. H&E shows number cells decreased significantly, arrangement chondrocytes became disordered group. RNA-seq analysis 195 upregulated 89 downregulated mRNAs top immune-related biological processes (Gene Ontology) regulation hormone secretion, peptide transcription involved cell fate commitment. KEGG pathway revealed IL-17 tumor necrosis factor signaling pathways significantly expressed, also genes. Also, Mmp3, Tnf, Mapk10, Ccl11, Creb5, Cxcl2, Cebpb enriched two pathways. showed levels Mmp3 Tnf proteins increased which consistent with results. This study critical roles TNF toxin.

Language: Английский

Citations

10
Unraveling the Nrf2-ARE Signaling Pathway in the DF-1 Chicken Fibroblast Cell Line: Insights into T-2 Toxin-Induced Oxidative Stress Regulation DOI Creative Commons

Suisui Gao,

Kaixin Wang,

Kuan-Kuan Xiong

et al.

Toxins, Journal Year: 2023, Volume and Issue: 15(11), P. 627 - 627

Published: Oct. 25, 2023

The T-2 toxin (T2) poses a major threat to the health and productivity of animals. present study aimed investigate regulatory mechanism Nrf2 derived from broilers against T2-induced oxidative damage. DF-1 cells, including those with normal characteristics, as well overexpressing or knockout specific components, were exposed 24 h treatment 50 nM T2. primary objective was evaluate indicators associated stress expression downstream antioxidant factors regulated by Nrf2-ARE signaling pathway, at both mRNA protein levels. findings this demonstrated noteworthy relationship between up-regulation considerable reduction in levels within cells (p < 0.05). Furthermore, notable increase pathway Conversely, down-regulation linked marked elevation Additionally, resulted significant decrease This experiment lays theoretical foundation for investigating detrimental impacts T2 on broiler chickens. It also establishes research framework employing chicken production breeding. Moreover, it introduces novel insights prospective management stress-related ailments livestock poultry industry.

Language: Английский

Citations

4
The Effects of T-2 Toxin, Deoxynivalenol, and Fumonisin B1 on Oxidative Stress-Related Genes in the Kidneys of Laying Hens DOI Creative Commons
Benjámin Kövesi, Szabina Kulcsár, Zsolt Ancsin

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(3), P. 154 - 154

Published: March 16, 2024

In the context of nephrotoxic risks associated with environmental contaminants, this study focused on impact mycotoxin exposure renal health laying hens, particular attention to oxidative stress pathways. Sixty hens were assigned three groups—a control group (CON), a low-dose (LOW), and high-dose (HIGH)—and monitored for 72 h. Mycotoxin contamination involved T-2/HT-2 toxin, DON/3-AcDON/15-AcDON, FB1 at their EU-recommended levels (low mix) double doses (high mix). Clinical assessments revealed no signs toxicity or notable weight changes. Analysis glutathione redox system parameters demonstrated that reduced content was lower than in controls 48 h higher Glutathione peroxidase activity increased response exposure. addition, gene expression patterns key redox-sensitive pathways, including Keap1-Nrf2-ARE AhR pathway, examined. Notably, profiles dynamic responses over time, underscoring intricate interplay redox-related mechanisms kidney. This sheds light early effects mixtures hens’ kidneys potential stress.

Language: Английский

Citations

1
Mycotoxins and coccidiosis in poultry – co-occurrence, interaction, and effects DOI Creative Commons

Luis-Miguel Gómez-Osorio,

Marko Vasiljević, Jog Raj

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 1, 2024

Avian coccidiosis, a common disease caused by

Language: Английский

Citations

1