Two-Dimensional Materials in Biosensing and Healthcare: FromIn VitroDiagnostics to Optogenetics and Beyond

ACS Nano, Год журнала: 2019, Номер 13(9), С. 9781 - 9810

Опубликована: Авг. 20, 2019

Since the isolation of graphene in 2004, there has been an exponentially growing number reports on layered two-dimensional (2D) materials for applications ranging from protective coatings to biochemical sensing. Due exceptional, and often tunable, electrical, optical, electrochemical, physical properties these materials, they can serve as active sensing element or a supporting substrate diverse healthcare applications. In this review, we provide survey recent 2D biosensing other emerging areas, wearable technologies optogenetics neural interfacing. Specifically, review provides (i) holistic evaluation relevant material across wide range systems, (ii) comparison material-based biosensors state-of-the-art, (iii) synthesis approaches specifically reported applications, (iv) technological considerations facilitate mass production commercialization.

Язык: Английский

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Is a Mask That Covers the Mouth and Nose Free from Undesirable Side Effects in Everyday Use and Free of Potential Hazards?

International Journal of Environmental Research and Public Health, Год журнала: 2021, Номер 18(8), С. 4344 - 4344

Опубликована: Апрель 20, 2021

Many countries introduced the requirement to wear masks in public spaces for containing SARS-CoV-2 making it commonplace 2020. Up until now, there has been no comprehensive investigation as adverse health effects can cause. The aim was find, test, evaluate and compile scientifically proven related side of wearing masks. For a quantitative evaluation, 44 mostly experimental studies were referenced, substantive 65 publications found. literature revealed relevant numerous disciplines. In this paper, we refer psychological physical deterioration well multiple symptoms described because their consistent, recurrent uniform presentation from different disciplines Mask-Induced Exhaustion Syndrome (MIES). We objectified evaluation evidenced changes respiratory physiology mask wearers with significant correlation O2 drop fatigue (p < 0.05), clustered co-occurrence impairment (67%), N95 CO2 rise (82%), (72%), headache (60%), temperature (88%), but also moisture (100%) under Extended mask-wearing by general population could lead consequences many medical fields.

Язык: Английский

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The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

Chemical Society Reviews, Год журнала: 2023, Номер 52(3), С. 879 - 920

Опубликована: Янв. 1, 2023

This tutorial review provides a general overview for the design of prodrugs and activatable phototherapeutics which enables development improved therapies.

Язык: Английский

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The Promise of Nanotechnology in Personalized Medicine

Journal of Personalized Medicine, Год журнала: 2022, Номер 12(5), С. 673 - 673

Опубликована: Апрель 22, 2022

Both personalized medicine and nanomedicine are new to medical practice. Nanomedicine is an application of the advances nanotechnology in being integrated into diagnostic therapeutic tools manage array conditions. On other hand, medicine, which also referred as precision a novel concept that aims individualize/customize management based on personal attributes patient overcome blanket treatment only efficient subset patients, leaving others with either ineffective or results significant toxicity. Novel nanomedicines have been employed several diseases, can be adapted each patient-specific case according their genetic profiles. In this review, we discuss both areas intersection between two emerging scientific domains. The review focuses current situation advantages offered by nanoconstructs diagnosis variability identify right drug for patient. Finally, touch upon challenges fields towards translation nano-personalized medicine.

Язык: Английский

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Digital twin for healthcare systems

Frontiers in Digital Health, Год журнала: 2023, Номер 5

Опубликована: Сен. 7, 2023

Digital twin technology is revolutionizing healthcare systems by leveraging real-time data integration, advanced analytics, and virtual simulations to enhance patient care, enable predictive optimize clinical operations, facilitate training simulation. With the ability gather analyze a wealth of from various sources, digital twins can offer personalized treatment plans based on individual characteristics, medical history, physiological data. Predictive analytics preventive interventions are made possible machine learning algorithms, allowing for early detection health risks proactive interventions. operations analyzing workflows resource allocation, leading streamlined processes improved care. Moreover, provide safe realistic environment professionals their skills practice complex procedures. The implementation in has potential significantly improve outcomes, safety, drive innovation industry.

Язык: Английский

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Integrative toxicogenomics: Advancing precision medicine and toxicology through artificial intelligence and OMICs technology

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 163, С. 114784 - 114784

Опубликована: Апрель 28, 2023

More information about a person's genetic makeup, drug response, multi-omics and genomic response is now available leading to gradual shift towards personalized treatment. Additionally, the promotion of non-animal testing has fueled computational toxicogenomics as pivotal part next-gen risk assessment paradigm. Artificial Intelligence (AI) potential provid new ways analyzing patient data making predictions treatment outcomes or toxicity. As medicine involve huge processing, AI can expedite this process by providing powerful analysis, interpretation algorithms. integrate multitude including genome data, records, clinical identify patterns derive predictive models anticipating assessing any approaches. In article, we have studied current trends future perspectives in & toxicology, role connecting two fields, impact on toxicology. work, also study key challenges limitations medicine, toxicogenomics, order fully realize their potential.

Язык: Английский

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Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine

Nanotheranostics, Год журнала: 2023, Номер 7(4), С. 424 - 449

Опубликована: Янв. 1, 2023

Medical imaging is an important factor for diagnosis.It can be used to diagnose patients, differentiate disease stages, and monitor treatment regimens.Although different technologies are available, MRI sensitive over other modalities as it capable of deep tissue penetration allowing image the anatomical, structural, molecular level diseased organs.Thus, screening tool staging.One components contrast agents which increase sensitivity technology.While types iron-oxide based nanoparticles (IONPS) widely these easy formulate, functionalize, biocompatible cost effective.In addition its use agents, have been drug carriers diseases ranging from cancer, cardiovascular diseases, neurological disorders, autoimmune infectious diseases.For last two decades, there has advancement in nanotheranostics, where IONPs formulated carry one system so that image-guided therapy real-life response tissue.This technology stratify patients into responders non-responders reduce adverse toxicity lead a tailored treatment.However, success nanotheranostics depends on several factor, including identification associated biomarkers targeted during formulation.While many challenges exist clinical translation still potential implemented personalized strategy.In this review article, we discussed relation their application diagnosis medicine.

Язык: Английский

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Anticancer Drug Discovery Based on Natural Products: From Computational Approaches to Clinical Studies

Biomedicines, Год журнала: 2024, Номер 12(1), С. 201 - 201

Опубликована: Янв. 16, 2024

Globally, malignancies cause one out of six mortalities, which is a serious health problem. Cancer therapy has always been challenging, apart from major advances in immunotherapies, stem cell transplantation, targeted therapies, hormonal precision medicine, and palliative care, traditional therapies such as surgery, radiation therapy, chemotherapy. Natural products are integral to the development innovative anticancer drugs cancer research, offering scientific community possibility exploring novel natural compounds against cancers. The role like Vincristine Vinblastine thoroughly implicated management leukemia Hodgkin’s disease. computational method initial key approach drug discovery, among various approaches. This review investigates synergy between techniques, highlights their significance discovery process. transition experimental validation highlighted through vitro vivo studies, with examples betulinic acid withaferin A. path toward therapeutic applications have demonstrated clinical studies silvestrol artemisinin, preclinical investigations trials. article also addresses challenges limitations potential anti-cancer drugs. Moreover, integration deep learning artificial intelligence methods may be useful for enhancing products.

Язык: Английский

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Effectiveness and safety of pulse oximetry in remote patient monitoring of patients with COVID-19: a systematic review

The Lancet Digital Health, Год журнала: 2022, Номер 4(4), С. e279 - e289

Опубликована: Март 22, 2022

The COVID-19 pandemic has led health systems to increase the use of tools for monitoring and triaging patients remotely. In this systematic review, we aim assess effectiveness safety pulse oximetry in remote patient (RPM) at home with COVID-19. We searched five databases (MEDLINE, Embase, Global Health, medRxiv, bioRxiv) from database inception April 15, 2021, included feasibility studies, clinical trials, observational including preprints. found 561 which 13 were our narrative synthesis. These studies all cohorts involved a total 2908 participants. A meta-analysis was not feasible owing heterogeneity outcomes reported studies. Our review substantiates potential COVID-19, identifying risk deterioration need advanced care. can potentially save hospital resources who might benefit most care escalation; however, could identify explicit evidence effect RPM on compared other models such as virtual wards, regular consultations, online or paper diaries monitor changes symptoms vital signs. Based findings, make 11 recommendations across three Donabedian model domains highlight specific measurements setting up an system oximetry.

Язык: Английский

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Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Фев. 16, 2023

Abstract Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly due to their inability timely administrate therapeutics precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials-driven transdermal rapid on-demand disease management. Through integration metamaterials, compact therapeutic patch is integrated penetration skin stratum corneum percutaneous transport with precise control dose rate over time. Moreover, device quantitatively regulates dosage release kinetics achieves better performance vivo than through subcutaneous injection. As proof-of-concept application, show our method can reverse life-threatening allergic reactions female mouse model anaphylaxis via multi-burst epinephrine, showing efficacy fixed injection which current gold standard ‘self-injectable epinephrine’ strategy. This innovative may provide promising means manage medicine.

Язык: Английский

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