Breast Cancer Targets and Therapy,
Год журнала:
2025,
Номер
Volume 17, С. 27 - 51
Опубликована: Янв. 1, 2025
Nanoparticle
technology
has
revolutionized
breast
cancer
treatment
by
offering
innovative
solutions
addressing
the
gaps
in
traditional
methods.
This
paper
aimed
to
comprehensively
explore
historical
journey
and
advancements
of
nanoparticles
treatment,
highlighting
their
transformative
impact
on
modern
medicine.
The
discussion
traces
evolution
nanoparticle-based
therapies
from
early
conceptualization
current
applications
future
potential.
We
initially
explored
context
limitations
conventional
therapies,
such
as
surgery,
radiation,
chemotherapy.
advent
nanotechnology
introduced
a
new
era
characterized
development
various
nanoparticles,
including
liposomes,
dendrimers,
gold
designed
target
cells
with
remarkable
precision.
further
described
mechanisms
action
for
passive
active
targeting,
reviewed
significant
breakthroughs
clinical
trials
that
have
validated
efficacy.
Current
been
examined,
showcasing
clinically
approved
comparing
effectiveness
article
also
discusses
latest
nanoparticle
research,
drug
delivery
systems
combination
therapy
innovations,
while
technical,
biological,
regulatory
challenges.
technical
challenges
include
efficient
targeted
tumor
sites
without
affecting
healthy
tissue;
potential
toxicity,
immune
system
activation,
or
resistance
mechanisms;
economic,
involving
high
production
scaling
costs;
regulatory,
requiring
rigorous
testing
safety,
efficacy,
long-term
effects
meet
stringent
approval
standards.
Finally,
we
emerging
trends,
personalized
medicine,
ethical
social
implications
this
technology.
In
conclusion,
through
comprehensive
analysis
case
studies,
underscores
profound
Life Sciences,
Год журнала:
2024,
Номер
352, С. 122899 - 122899
Опубликована: Июль 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Molecules,
Год журнала:
2024,
Номер
29(20), С. 4854 - 4854
Опубликована: Окт. 13, 2024
Biological
variability
poses
significant
challenges
in
the
development
of
effective
therapeutics,
particularly
when
it
comes
to
drug
solubility
and
bioavailability.
Poor
across
varying
physiological
conditions
often
leads
reduced
absorption
inconsistent
therapeutic
outcomes.
This
review
examines
how
nanotechnology,
especially
through
use
nanomaterials
magnetic
nanoparticles,
offers
innovative
solutions
enhance
comprehensive
focuses
on
recent
advancements
approaches
nanotechnology.
We
highlight
both
successes
remaining
this
field,
emphasizing
role
continued
innovation.
Future
research
should
prioritize
developing
universal
solutions,
conducting
interdisciplinary
research,
leveraging
personalized
nanomedicine
address
biological
variability.
ACS Omega,
Год журнала:
2024,
Номер
9(31), С. 33303 - 33334
Опубликована: Июль 25, 2024
The
increasing
occurrence
of
infectious
diseases
caused
by
antimicrobial
resistance
organisms
urged
the
necessity
to
develop
more
potent,
selective,
and
safe
agents.
unique
magnetic
tunable
properties
iron
oxide
nanoparticles
(IONPs)
make
them
a
promising
candidate
for
different
theragnostic
applications,
including
Though
IONPs
act
as
nonspecific
agent,
their
activities
are
directly
or
indirectly
linked
with
synthesis
methods,
synthesizing
precursors,
size,
shapes,
concentration,
surface
modifications.
Alteration
these
parameters
could
accelerate
decelerate
production
reactive
oxygen
species
(ROS).
An
increase
in
ROS
role
disrupts
bacterial
cell
walls,
membranes,
alters
major
biomolecules
(e.g.,
lipids,
proteins,
nucleic
acids),
affects
metabolic
processes
Krebs
cycle,
fatty
acid
synthesis,
ATP
glycolysis,
mitophagy).
In
this
review,
we
will
investigate
antibacterial
activity
bare
surface-modified
influence
physiochemical
on
activity.
Additionally,
report
potential
mechanism
IONPs'
action
driving
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 19 - 34
Опубликована: Янв. 1, 2024
Abstract:
Peripheral
nerve
injuries,
arising
from
a
diverse
range
of
etiologies
such
as
trauma
and
underlying
medical
conditions,
pose
substantial
challenges
in
both
clinical
management
subsequent
restoration
functional
capacity.
Addressing
these
challenges,
nanoparticles
have
emerged
promising
therapeutic
modality
poised
to
augment
the
process
peripheral
regeneration.
However,
comprehensive
elucidation
complicated
mechanistic
foundations
responsible
for
favorable
effects
nanoparticle-based
therapy
on
regeneration
remains
imperative.
This
review
aims
scrutinize
potential
innovative
carriers
promoting
repair.
encompasses
an
in-depth
exploration
classifications
synthesis
methodologies
associated
with
nanoparticles.
Additionally,
we
discuss
summarize
multifaceted
roles
that
play,
including
neuroprotection,
facilitation
axonal
growth,
efficient
drug
delivery
mechanisms.
Furthermore,
present
essential
considerations
highlight
synergies
integrating
emerging
technologies.
Through
this
review,
indispensable
role
propelling
advancements
Keywords:
nanoparticle,
nanomedicine,
biomaterials,
regeneration,
tissue
