Unveiling the Mechanisms of Pain in Endometriosis: Comprehensive Analysis of Inflammatory Sensitization and Therapeutic Potential

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1770 - 1770

Опубликована: Фев. 19, 2025

Endometriosis is a complicated, estrogen-dependent gynecological condition with high morbidity rate. Pain, as the most common clinical symptom of endometriosis, severely affects women's physical and mental health exacerbates socioeconomic burden. However, specific mechanisms behind occurrence endometriosis-related pain remain unclear. It currently believed that endometriosis related to various factors, such immune abnormalities, endocrine disorders, brain-gut axis, angiogenesis, mechanical stimulation. These factors induce systemic chronic inflammation, which stimulates nerves subsequently alters neural plasticity, leading nociceptive sensitization thereby causing pain. In this paper, we compile review articles published on study mechanisms. Starting from influencing associated explain relationship between these inflammation further elaborate potential by induces sensitization. We aim reveal possible pain, well sensitization, offer new targets for treatment

Язык: Английский

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Broadening horizons: microbiota as a novel biomarker and potential treatment for endometriosis

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

As a heterogeneous disease, endometriosis is associated with diagnostic delay. Delayed diagnosis, physical discomfort, hormone therapy, and inconvenience in daily life work all contribute to decreased quality of for patients. Early clinical diagnosis highly important the intervention treatment endometriosis. Currently, reliable non-invasive methods are lacking, laparoscopic examination combined pathological considered "gold standard" definitively diagnosing An increasing number studies have confirmed correlation between microbial ecological changes. Microbial dysbiosis an factor development progression Certain key species their metabolites can induce functional alterations endometrial cells through various mechanisms, often preceding emergence symptoms. Endometriosis chronic inflammatory diseases, immunoinflammatory response as foundation. The microbiome may participate mechanisms multiple pathways, including mediating responses, regulating immune participating estrogen regulation, interfering metabolic activities, modulating gut-brain axis. Therefore, holds potential early therapeutic target This study summarizes analyses correlations microorganisms onset endometriosis, aiming provide novel insights into etiology,

Язык: Английский

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Gut Microbiota Disorder Contributes to the Production of IL-17A That Exerts Chemotaxis via Binding to IL-17RA in Endometriosis

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 4199 - 4217

Опубликована: Июль 1, 2024

Endometriosis (EM) is a chronic estrogen-dependent condition characterized by the growth of endometrial-like tissue outside uterus, posing significant burden on reproductive-aged women. Previous research has shown correlation between gut microbiota dysbiosis and interleukin-17A (IL-17A) in EM patients. IL-17A, promising immunomodulatory molecule, exerts dual roles human physiology, driving inflammatory diseases. However, functions origins IL-17A remain poorly characterized.

Язык: Английский

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The effect of the female genital tract and gut microbiome on reproductive dysfunction

BioScience Trends, Год журнала: 2023, Номер 17(6), С. 458 - 474

Опубликована: Дек. 16, 2023

Microorganisms are ubiquitous in the human body; they present various areas including gut, mouth, skin, respiratory tract, and reproductive tract. The interaction between microbiome health has become an increasingly compelling area of study. Disruption female genital tract can significantly impact metabolism amino acids, carbohydrates, lipids, increasing susceptibility to diseases such as vaginitis, chronic endometritis, endometrial polyps, endometriosis, polycystic ovary syndrome. gut microbiome, considered endocrine organ, plays a crucial role system by interacting with hormones like estrogen androgens. Imbalances composition lead conditions, syndrome, cancer, although research on their mechanisms remains limited. This review highlights latest advancements understanding microbiomes gynecological diseases. It also explores potential microbial communities treatment Future should focus identifying molecular underlying association develop new effective strategies for disease prevention, diagnosis, related organs.

Язык: Английский

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Gut Microbiota and Endometriosis: Exploring the Relationship and Therapeutic Implications

Pharmaceuticals, Год журнала: 2023, Номер 16(12), С. 1696 - 1696

Опубликована: Дек. 7, 2023

Endometriosis is a common inflammatory disease affecting women of reproductive age, characterized by the growth endometrial tissue beyond uterus. In addition to gynecological manifestations, many endometriosis patients experience gastrointestinal symptoms, indicating potential association between gut health and disease. Recent studies have revealed alterations in microbiota individuals with endometriosis, including reduced diversity, microbial composition imbalances, pathogenic bacteria. These changes can disrupt immune function, increase inflammation, contribute chronic state observed endometriosis. Moreover, dysregulation intestinal permeability may further exacerbate symptoms affected individuals. Understanding role provide valuable insights into pathogenesis, aid non-invasive diagnostic approaches, open new avenues for therapeutic interventions. Probiotics, particular, shown promise improving endometriosis-associated pain reducing endometriotic lesions animal models. This review suggests that additional research well-designed clinical trials are necessary validate benefits manipulating managing its thereby quality life those affected.

Язык: Английский

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Discovery of a botanical compound as a broad-spectrum inhibitor against gut microbial β-glucuronidases from the Tibetan medicine Rhodiola crenulata

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 267, С. 131150 - 131150

Опубликована: Март 29, 2024

Язык: Английский

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Relationship between the gut microbiome and endometriosis and its role in pathogenesis, diagnosis, and treatment: a systematic review

Ginekologia Polska, Год журнала: 2023, Номер unknown

Опубликована: Сен. 28, 2023

Endometriosis is a chronic inflammatory disease affecting approximately 10% of women. It defined as endometrial tissue outside the uterus and produces variety symptoms including pelvic pain, dysmenorrhea, dyspareunia, intermenstrual bleeding. Although several theories have been postulated regarding pathogenesis endometriosis, no theory has provided complete explanation, therefore limiting our progress in diagnostic tools management endometriosis. Recently, much attention paid to importance role gut microbiome As by Joshua Lederberg — set genome microorganisms inhabiting human body, commensal, symbiotic pathogenic microorganisms. The aim this systematic review was conduct search Embase, Medline, PubMed databases for literature from July 2013 2023 relationship between 147 records were screened, which 26 met eligibility criteria, 16 included review. Our concludes that patients with endometriosis show an altered microbiome, potential provide insight pathogenesis, markers diagnosis, well therapeutic options treatment Future research necessary confirm further investigate

Язык: Английский

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Gut microbiome in endometriosis: a cohort study on 1,000 individuals

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Янв. 25, 2024

Abstract Background Endometriosis, defined as the presence of endometrial-like tissue outside uterus, is one most prevalent gynecological disorders. Although different theories have been proposed, its pathogenesis not clear. Novel studies indicate that gut microbiome may be involved in etiology endometriosis, nevertheless, connection between microbes, their dysbiosis and development endometriosis understudied. This case-control study analyzed women with without to identify microbial targets disease. Methods A subsample 1,000 from Estonian Microbiome cohort, including 136 864 control women, was analyzed. Microbial composition determined by shotgun metagenomics functional pathways were annotated using Kyoto Encyclopedia Genes Genomes (KEGG) database. Partitioning around medoids (PAM) algorithm performed cluster profile population. The alpha- beta-diversity differential abundance analyses assess (species KEGG orthologies [KO]) both groups. Metagenomic reads mapped estrobolome-related enzymes’ sequences potential microbiome-estrogen metabolism axis alterations endometriosis. Results Diversity did detect significant differences (Alpha-diversity: all p-values > 0.05; Beta-diversity: PERMANOVA, R 2 < 0.0007, 0.05). No species or detected after multiple testing adjustment (all FDR Sensitivity analysis excluding at menopause (> 50 years) confirmed our results. Estrobolome-associated significantly groups Conclusions Our findings do provide enough evidence support existence a microbiome-dependent mechanism directly implicated To best knowledge, this largest metagenome on conducted date.

Язык: Английский

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Beyond the reproductive tract: gut microbiome and its influence on gynecological health

Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2024, Номер unknown

Опубликована: Апрель 9, 2024

Purpose of review The analysis microbiome in association with female health is today a “hot topic” the main focus on microbes reproductive tract. Nevertheless, recent studies are providing novel information possible influence gut gynecological outcomes, especially as we start to understand that an extended endocrine organ influencing hormonal levels. This summarizes current knowledge health. Recent findings has been associated endometriosis, polycystic ovary syndrome, cancers, and infertility, although there lack consistency consensus among due different study designs protocols used, general underpowered. Summary interconnection between complex further research warranted. field emphasizes link high potential for diagnostic treatment tools via modulation microenvironment.

Язык: Английский

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Causal effects between gut microbiota and endometriosis: a two-sample Mendelian randomisation study

Journal of Obstetrics and Gynaecology, Год журнала: 2024, Номер 44(1)

Опубликована: Июнь 17, 2024

Background Previous observational evidence has indicated the potential involvement of gut microbiota (GM) in development endometriosis. However, causal relationship association remains to be investigated.

Язык: Английский

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