European Journal of Medicinal Chemistry Reports, Год журнала: 2024, Номер 12, С. 100179 - 100179
Опубликована: Июнь 18, 2024
Five derived forms of 2-oxo-2-H-chromene clubbed guanine, thiazole and imidazoline derivatives 10 (i–v), 11 12 (i–v) were synthesized, characterized, biologically tested for in vitro antimicrobial activity against two types bacteria viz. Staphylococcus aureus (MTCC 87) Escherichia coli 40). The synthesized compounds demonstrated mild to moderate antibacterial at all concentrations (100 μg/ml, 250 500 μg/ml) comparison standard drug ciprofloxacin. It was observed that the 10i, 10v, 11i, 11v, 12i, 12ii, 12iv 12v have noticeable higher dose drug. Zone inhibition values indicated μg/ml case coumarin guanine derivatives. been found be potent lower having negligible 100 μg/ml. This suggests a differential efficacy profile among compounds, with showing promising doses while imidazole manifesting increased potency concentrations. These findings underscore potential these novel as agents, warranting further investigation into their mechanisms action therapeutic applications.
Язык: Английский