European Journal of Medicinal Chemistry Reports,
Journal Year:
2024,
Volume and Issue:
12, P. 100179 - 100179
Published: June 18, 2024
Five
derived
forms
of
2-oxo-2-H-chromene
clubbed
guanine,
thiazole
and
imidazoline
derivatives
10
(i–v),
11
12
(i–v)
were
synthesized,
characterized,
biologically
tested
for
in
vitro
antimicrobial
activity
against
two
types
bacteria
viz.
Staphylococcus
aureus
(MTCC
87)
Escherichia
coli
40).
The
synthesized
compounds
demonstrated
mild
to
moderate
antibacterial
at
all
concentrations
(100
μg/ml,
250
500
μg/ml)
comparison
standard
drug
ciprofloxacin.
It
was
observed
that
the
10i,
10v,
11i,
11v,
12i,
12ii,
12iv
12v
have
noticeable
higher
dose
drug.
Zone
inhibition
values
indicated
μg/ml
case
coumarin
guanine
derivatives.
been
found
be
potent
lower
having
negligible
100
μg/ml.
This
suggests
a
differential
efficacy
profile
among
compounds,
with
showing
promising
doses
while
imidazole
manifesting
increased
potency
concentrations.
These
findings
underscore
potential
these
novel
as
agents,
warranting
further
investigation
into
their
mechanisms
action
therapeutic
applications.
