Journal of CO2 Utilization, Год журнала: 2024, Номер 91, С. 102995 - 102995
Опубликована: Дек. 15, 2024
RSC Pharmaceutics, Год журнала: 2024, Номер 1(2), С. 182 - 203
Опубликована: Янв. 1, 2024
Native cassava starch and its derivatives have found great use in the pharmaceutical sector for development of various novel conventional drug delivery carriers.
Язык: Английский
Процитировано
9
Case Studies in Thermal Engineering, Год журнала: 2024, Номер 61, С. 105074 - 105074
Опубликована: Сен. 1, 2024
The complete investigation of the solubility Ceftriaxone sodium drug has not yet been conducted. This communication investigates in supercritical CO2 (SC-CO2) for first time. measurements were performed using utilizing UV-vis analysis under different operation conditions (at P (bar) = 120-270 and T (K) 308-338). results demonstrated that ranged from 0.90 × 10-6 to 8.01 10-6. mole fraction increases proportionally with an increase pressure, while maintaining a constant temperature. However, crossover was noted. behavior SC-CO2 modeled by Peng-Robinson equation state (PR EoS) Kwak-Mansoori van der Waals mixing rules seven semi-empirical correlations (Bian et al., Kumar-Johnston, Chrastil, Garlapati-Madras, Bartle Sung-Shim Sodeifian al.,). vaporization, total solvation enthalpies sodium/SC-carbon dioxide system obtained KJ, al. correlations. evaluation two methods absolute average relative deviation (AARD%). Both models exhibited satisfactory level agreement experimental data. Finally, PR/KM EoS Chrastil models, AARD% values 8.70% 8.10% respectively, showed superior precision accurately fitting
Язык: Английский
Процитировано
9
Journal of Chemical & Engineering Data, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
This study investigates the solubility of Baclofen in supercritical CO2, which is essential for developing an efficient drug delivery system using processes. Solubility measurements were carried out both with and without presence various cosolvents (ethanol dimethyl sulfoxide (DMSO)), across a temperature range 308–338 K pressure 12–30 MPa. exhibited ranging from 1.62 × 10–5 to 2.30 mole fractions pure CO2. In cosolvents, increased 5.76 12.79 ethanol 3.50 7.02 DMSO. Indeed, addition DMSO by approximately 3.55–5.56 times 2.15–3.05 times, respectively. Several density-based empirical models thermodynamic (Soave–Redlich–Kwong (SRK) Peng–Robinson (PR) equations state) used correlate data. Jafari Nejad's model CO2–Baclofen Jouyban's CO2–ethanol/DMSO–Baclofen systems displayed higher consistency. Also, PR showed better accuracy correlating while SRK outperformed CO2–ethanol/DMSO cosolvents. Moreover, machine learning exceptional accuracy, over 99% predictions closely matching experimental data, emphasizing its outstanding performance.
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Ноя. 29, 2023
In this study, the solubilities of codeine phosphate, a widely used pain reliever, in supercritical carbon dioxide (SC-CO2) were measured under various pressures and temperature conditions. The lowest determined mole fraction phosphate SC-CO2 was 1.297 × 10-5 at 308 K 12 MPa, while highest 6.502 338 27 MPa. These then modeled using equation state model, specifically Peng-Robinson model. A selection density models, including Chrastil Mendez-Santiago Teja Bartle et al. Sodeifian Reddy-Garlapati also employed. Additionally, three forms solid-liquid equilibrium commonly called expanded liquid models (ELMs), used. average solvation enthalpy associated with solubility calculated to be - 16.97 kJ/mol. ELMs provided satisfactory correlation data, corresponding absolute relative deviation percent (AARD%) 12.63%. most accurate ELM model recorded AARD% AICc values 8.89% 589.79, respectively.
Язык: Английский
Процитировано
14
Journal of CO2 Utilization, Год журнала: 2024, Номер 91, С. 102995 - 102995
Опубликована: Дек. 15, 2024
Процитировано
6