Production of pazopanib hydrochloride nanoparticles (anti-kidney cancer drug) using a supercritical gas antisolvent (GAS) method DOI Creative Commons

Majid Bazaei,

Bizhan Honarvar, Nadia Esfandiari

и другие.

RSC Advances, Год журнала: 2024, Номер 14(54), С. 39844 - 39857

Опубликована: Янв. 1, 2024

Supercritical fluid-based methods have been receiving increasing popularity in the production of pharmaceutical nanoparticles due to their ability control size and distribution particles offer high purity products.

Язык: Английский

Solubility measurement of Ceftriaxone sodium in SC-CO2 and thermodynamic modeling using PR-KM EoS and vdW mixing rules with semi-empirical models DOI Creative Commons
Gholamhossein Sodeifian, Hamidreza Bagheri, Mohsen Ashjari

и другие.

Case Studies in Thermal Engineering, Год журнала: 2024, Номер 61, С. 105074 - 105074

Опубликована: Сен. 1, 2024

The complete investigation of the solubility Ceftriaxone sodium drug has not yet been conducted. This communication investigates in supercritical CO2 (SC-CO2) for first time. measurements were performed using utilizing UV-vis analysis under different operation conditions (at P (bar) = 120-270 and T (K) 308-338). results demonstrated that ranged from 0.90 × 10-6 to 8.01 10-6. mole fraction increases proportionally with an increase pressure, while maintaining a constant temperature. However, crossover was noted. behavior SC-CO2 modeled by Peng-Robinson equation state (PR EoS) Kwak-Mansoori van der Waals mixing rules seven semi-empirical correlations (Bian et al., Kumar-Johnston, Chrastil, Garlapati-Madras, Bartle Sung-Shim Sodeifian al.,). vaporization, total solvation enthalpies sodium/SC-carbon dioxide system obtained KJ, al. correlations. evaluation two methods absolute average relative deviation (AARD%). Both models exhibited satisfactory level agreement experimental data. Finally, PR/KM EoS Chrastil models, AARD% values 8.70% 8.10% respectively, showed superior precision accurately fitting

Язык: Английский

Процитировано

9

Thermodynamic assessment for Rivaroxaban nanoparticle production using GAS anti-solvent (GAS) Process: Synthesis and Characterization DOI

Mahshid Askarizadeh,

Nadia Esfandiari, Bizhan Honarvar

и другие.

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127125 - 127125

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigation DOI Creative Commons
Gholamhossein Sodeifian, Hamidreza Bagheri,

Farnoush Masihpour

и другие.

Journal of CO2 Utilization, Год журнала: 2024, Номер 91, С. 102995 - 102995

Опубликована: Дек. 15, 2024

Процитировано

6

Comprehensive study of medications solubility in supercritical CO2 with and without co-solvent; Laboratory, theoretical, and intelligent approaches DOI
Chou‐Yi Hsu, Dheyaa J. Jasim, Pooja Bansal

и другие.

Journal of Molecular Liquids, Год журнала: 2024, Номер 411, С. 125765 - 125765

Опубликована: Авг. 13, 2024

Язык: Английский

Процитировано

4

Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling DOI Creative Commons
Seyed Ali Sajadian, Nadia Esfandiari, Adrián Rojas

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 31, 2025

In this study, the solubility of mesalazine in supercritical carbon dioxide with and without cosolvent was carried out for first time at different temperatures pressure values ranging from 308 to 338 K 12 30 MPa, respectively. The determined experimental molar solubilities were range 4.41 × 10-5 9.97 (308 K), 3.9 13.1 (318 3.4 16 (328 K) 3.3 18.4 (338 K). Meanwhile, using 2% dimethyl sulfoxide as 28.22 36.2 26.07 51.41 25.02 69.07 25.86 82.6 A novel association model employed simulate data binary ternary systems. Various semiempirical correlations utilized calculate dioxide. new deemed most superior model, achieving an average absolute relative deviation value 4.13% a cosolvent, 3.36% when included.

Язык: Английский

Процитировано

0

Recast Solubility Models for Correlating Solubility of Solid Drugs in Supercritical Carbon Dioxide DOI
Raghavan Amrithaa,

Vikram Ramalingam,

Chandrasekhar Garlapati

и другие.

Chemical Engineering & Technology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Abstract Solubilities of solid drugs in supercritical fluids were well represented by density models and mathematical models. In literature, several solubility reported, some them observed to be redundant according Gibbs phase rule. Therefore, the present work is aimed address nature recasting existing with help equation state (EoS). Solubility proposed Adachi–Lu, Garlapati–Madras, Keshmiri et al., Si‐Moussa Belghait Sodeifian al. model 1, 2 considered for study. Existing recast versions evaluated literature reported 20 drug compound's data carbon dioxide.

Язык: Английский

Процитировано

0

Solubility of Teriflunomide in Supercritical Carbon Dioxide and Co-Solvent Investigation DOI

Mahshid Askarizadeh,

Nadia Esfandiari, Bizhan Honarvar

и другие.

Fluid Phase Equilibria, Год журнала: 2024, Номер 590, С. 114284 - 114284

Опубликована: Ноя. 14, 2024

Язык: Английский

Процитировано

1

Measuring and modeling the solubility of sulfasalazine in supercritical carbon dioxide to select methods for producing nanoparticles DOI Creative Commons

Yahia Alghazwani,

Mohammed Ghazwani, Sirajunisa Talath

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 4, 2024

In the present study, solubility of sulfasalazine in carbon dioxide was investigated at temperatures ranging from 313 K to 343 and pressures 12 30 MPa. The experimentally determined molar solubilities ScCO2 were found be range 4.08 × 10− 5 8.61 K, 3.54 11.41 323 3.04 13.64 333 2.66 16.35 K. values correlated via a number different types equations, such as semi-empirical correlations, Peng-Robinson, PC-SAFT equation, regular solution. Furthermore, findings demonstrate that semi-empirical, equation state models, solution model possess capability precisely determining solubility. Moreover, magnitude suggests gas anti-solvent method may viable approach for nanoparticle production.

Язык: Английский

Процитировано

0

Production of pazopanib hydrochloride nanoparticles (anti-kidney cancer drug) using a supercritical gas antisolvent (GAS) method DOI Creative Commons

Majid Bazaei,

Bizhan Honarvar, Nadia Esfandiari

и другие.

RSC Advances, Год журнала: 2024, Номер 14(54), С. 39844 - 39857

Опубликована: Янв. 1, 2024

Supercritical fluid-based methods have been receiving increasing popularity in the production of pharmaceutical nanoparticles due to their ability control size and distribution particles offer high purity products.

Язык: Английский

Процитировано

0