Solubility measurement of Ceftriaxone sodium in SC-CO2 and thermodynamic modeling using PR-KM EoS and vdW mixing rules with semi-empirical models
Case Studies in Thermal Engineering,
Год журнала:
2024,
Номер
61, С. 105074 - 105074
Опубликована: Сен. 1, 2024
The
complete
investigation
of
the
solubility
Ceftriaxone
sodium
drug
has
not
yet
been
conducted.
This
communication
investigates
in
supercritical
CO2
(SC-CO2)
for
first
time.
measurements
were
performed
using
utilizing
UV-vis
analysis
under
different
operation
conditions
(at
P
(bar)
=
120-270
and
T
(K)
308-338).
results
demonstrated
that
ranged
from
0.90
×
10-6
to
8.01
10-6.
mole
fraction
increases
proportionally
with
an
increase
pressure,
while
maintaining
a
constant
temperature.
However,
crossover
was
noted.
behavior
SC-CO2
modeled
by
Peng-Robinson
equation
state
(PR
EoS)
Kwak-Mansoori
van
der
Waals
mixing
rules
seven
semi-empirical
correlations
(Bian
et
al.,
Kumar-Johnston,
Chrastil,
Garlapati-Madras,
Bartle
Sung-Shim
Sodeifian
al.,).
vaporization,
total
solvation
enthalpies
sodium/SC-carbon
dioxide
system
obtained
KJ,
al.
correlations.
evaluation
two
methods
absolute
average
relative
deviation
(AARD%).
Both
models
exhibited
satisfactory
level
agreement
experimental
data.
Finally,
PR/KM
EoS
Chrastil
models,
AARD%
values
8.70%
8.10%
respectively,
showed
superior
precision
accurately
fitting
Язык: Английский
Thermodynamic assessment for Rivaroxaban nanoparticle production using GAS anti-solvent (GAS) Process: Synthesis and Characterization
Journal of Molecular Liquids,
Год журнала:
2025,
Номер
unknown, С. 127125 - 127125
Опубликована: Фев. 1, 2025
Язык: Английский
Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigation
Journal of CO2 Utilization,
Год журнала:
2024,
Номер
91, С. 102995 - 102995
Опубликована: Дек. 15, 2024
Comprehensive study of medications solubility in supercritical CO2 with and without co-solvent; Laboratory, theoretical, and intelligent approaches
Journal of Molecular Liquids,
Год журнала:
2024,
Номер
411, С. 125765 - 125765
Опубликована: Авг. 13, 2024
Язык: Английский
Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 31, 2025
In
this
study,
the
solubility
of
mesalazine
in
supercritical
carbon
dioxide
with
and
without
cosolvent
was
carried
out
for
first
time
at
different
temperatures
pressure
values
ranging
from
308
to
338
K
12
30
MPa,
respectively.
The
determined
experimental
molar
solubilities
were
range
4.41
×
10-5
9.97
(308
K),
3.9
13.1
(318
3.4
16
(328
K)
3.3
18.4
(338
K).
Meanwhile,
using
2%
dimethyl
sulfoxide
as
28.22
36.2
26.07
51.41
25.02
69.07
25.86
82.6
A
novel
association
model
employed
simulate
data
binary
ternary
systems.
Various
semiempirical
correlations
utilized
calculate
dioxide.
new
deemed
most
superior
model,
achieving
an
average
absolute
relative
deviation
value
4.13%
a
cosolvent,
3.36%
when
included.
Язык: Английский
Recast Solubility Models for Correlating Solubility of Solid Drugs in Supercritical Carbon Dioxide
Chemical Engineering & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Abstract
Solubilities
of
solid
drugs
in
supercritical
fluids
were
well
represented
by
density
models
and
mathematical
models.
In
literature,
several
solubility
reported,
some
them
observed
to
be
redundant
according
Gibbs
phase
rule.
Therefore,
the
present
work
is
aimed
address
nature
recasting
existing
with
help
equation
state
(EoS).
Solubility
proposed
Adachi–Lu,
Garlapati–Madras,
Keshmiri
et
al.,
Si‐Moussa
Belghait
Sodeifian
al.
model
1,
2
considered
for
study.
Existing
recast
versions
evaluated
literature
reported
20
drug
compound's
data
carbon
dioxide.
Язык: Английский
Solubility of Teriflunomide in Supercritical Carbon Dioxide and Co-Solvent Investigation
Fluid Phase Equilibria,
Год журнала:
2024,
Номер
590, С. 114284 - 114284
Опубликована: Ноя. 14, 2024
Язык: Английский
Measuring and modeling the solubility of sulfasalazine in supercritical carbon dioxide to select methods for producing nanoparticles
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 4, 2024
In
the
present
study,
solubility
of
sulfasalazine
in
carbon
dioxide
was
investigated
at
temperatures
ranging
from
313
K
to
343
and
pressures
12
30
MPa.
The
experimentally
determined
molar
solubilities
ScCO2
were
found
be
range
4.08
×
10−
5
8.61
K,
3.54
11.41
323
3.04
13.64
333
2.66
16.35
K.
values
correlated
via
a
number
different
types
equations,
such
as
semi-empirical
correlations,
Peng-Robinson,
PC-SAFT
equation,
regular
solution.
Furthermore,
findings
demonstrate
that
semi-empirical,
equation
state
models,
solution
model
possess
capability
precisely
determining
solubility.
Moreover,
magnitude
suggests
gas
anti-solvent
method
may
viable
approach
for
nanoparticle
production.
Язык: Английский
Production of pazopanib hydrochloride nanoparticles (anti-kidney cancer drug) using a supercritical gas antisolvent (GAS) method
RSC Advances,
Год журнала:
2024,
Номер
14(54), С. 39844 - 39857
Опубликована: Янв. 1, 2024
Supercritical
fluid-based
methods
have
been
receiving
increasing
popularity
in
the
production
of
pharmaceutical
nanoparticles
due
to
their
ability
control
size
and
distribution
particles
offer
high
purity
products.
Язык: Английский