International Journal of Biological Macromolecules, Год журнала: 2024, Номер 293, С. 139370 - 139370
Опубликована: Дек. 30, 2024
Язык: Английский
Phytomedicine, Год журнала: 2025, Номер 138, С. 156402 - 156402
Опубликована: Янв. 18, 2025
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134832 - 134832
Опубликована: Авг. 22, 2024
Язык: Английский
Процитировано
14
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Авг. 28, 2024
Gut microecology,the complex community consisting of microorganisms and their microenvironments in the gastrointestinal tract, plays a vital role maintaining overall health regulating various physiological pathological processes. Recent studies have highlighted significant impact gut microecology on regulation uric acid metabolism. Natural products, including monomers, extracts, traditional Chinese medicine formulations derived from natural sources such as plants, animals, microorganisms, also been investigated for potential modulating According to research, The stability is crucial link products maintain healthy metabolism reduce hyperuricemia-related diseases. Herein, we review recent advanced evidence revealing bidirectional between And separately summarize key extracts herbal both aspects. In addition,we elucidated important mechanisms secondary diseases through microecology, especially by composition microbiota, mucosal barrier, inflammatory response, purine catalyzation, associated transporters. This may offer novel insight into its disorders management highlight perspective exploring therapeutic drugs products.
Язык: Английский
Процитировано
7
Heliyon, Год журнала: 2024, Номер 10(23), С. e40563 - e40563
Опубликована: Ноя. 22, 2024
Язык: Английский
Процитировано
6
eFood, Год журнала: 2025, Номер 6(1)
Опубликована: Янв. 3, 2025
ABSTRACT Hyperuricemia (HUA) is one of main risk factors for liver injury, and xanthine oxidase (XOD) an important target HUA‐induced injury. As a typical natural active ingredient, naringenin (NAR) has been confirmed the good therapeutic effect on variety diseases. However, studies NAR ameliorating injury have not reported. Therefore, we evaluated bioactivity in investigated related molecular mechanisms. The inhibitory activity type XOD was by enzymatic reactions kinetic analyses, docking showed that able to bind tightly XOD. In vivo ameliorated function while being inhibit activity. alleviated oxidative stress caused excess reactive oxygen species through antioxidant At same time, exerted anti‐inflammatory regulating levels inflammatory factors. results suggested interact with Keap1 AMPK exhibit effects. This work demonstrated which valuable further development functional foods.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1317 - 1317
Опубликована: Фев. 4, 2025
Bioactive peptides, composed of amino acid chains, are fundamental to a wide range biological functions. Their inherent multifunctionality, however, complicates accurate classification and prediction. To address these challenges, we present MFP-MFL, an advanced multi-feature, multi-label learning framework that integrates Graph Attention Networks (GAT) with leading protein language models, including ESM-2, ProtT5, RoBERTa. By employing ensemble strategy, MFP-MFL effectively utilizes deep sequence features complex functional dependencies, ensuring highly robust predictions multifunctional peptides. Comparative experiments demonstrate achieves precision, coverage, accuracy scores 0.799, 0.821, 0.786, respectively. Additionally, it attains Absolute true 0.737 while maintaining low false 0.086. A comprehensive case study involving 86,970 mutations further highlights the model’s ability predict changes resulting from variations. These results establish as powerful tool for discovery application offering significant potential advance research biomedical applications.
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106112 - 106112
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 150, С. 114214 - 114214
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 19
Опубликована: Фев. 28, 2025
Hyperuricemia, characterized by an elevation in serum uric acid (UA) levels, stands as a significant metabolic ailment threatening human well-being. Presently, dietary adjustments have become crucial strategy managing UA levels among individuals grappling with hyperuricemia and gout. Given its unique ecosystem, the ocean hosts plethora of organisms boasting distinct structures active components. The marine bioactive substances, such peptides, polysaccharides, lipids, small molecules, garnered attention research development modern functional foods biomedicine due to their profound efficacy distinctive compositions. Notably, components been studied for potential preventing hyperuricemia. However, precise molecular mechanism underlying actions remain incompletely elucidated. This review article highlights diversity compounds latest progress understanding urate-lowering mechanism. Principal mechanisms primarily encompass regulation metabolism, maintenance intestinal homeostasis, mitigation inflammatory responses, alleviation oxidative stress. Furthermore, we scrutinized constraints prior studies provided recommendations. In sum, this furnished valuable resource concerning intervention sourced from context
Язык: Английский
Процитировано
0
Journal of Food Composition and Analysis, Год журнала: 2025, Номер 142, С. 107446 - 107446
Опубликована: Март 3, 2025
Язык: Английский
Процитировано
0