Molecular Nutrition & Food Research, Год журнала: 2024, Номер unknown
Опубликована: Дек. 15, 2024
Lactobacillus acidophilus L. Lactobacillus, Bifidobacterium, and Akkermansia, This study aimed to explore the ameliorative effects underlying mechanisms of oral administration 6074 fermented jujube juice (LAFJ) on dextran sulfate sodium (DSS)-induced colitis in mice. In this study, was used as a substrate by investigate its gut microbiota, intestinal barrier function, oxidative stress, inflammatory factors, short-chain fatty acids (SCFAs) mice with reveal potential mechanism for alleviating colitis. The results demonstrated that fermentation caused significant changes nutrients nonnutrients juice, mainly organic (malic acid, lactic citric succinic acid) free amino (Thr, Met, Ser, Ile, Lys). High-dose LAFJ (20 mL/kg/day) significantly reduced disease activity index (DAI), improved histopathological morphology, increased colon length alleviated damage preserved integrity colonic mucosal promoting expression tight junction proteins occludin, claudin-1, zonula occluden-1 (ZO-1). Furthermore, inhibited production proinflammatory factors attenuated stress. Gut microbiota revealed beneficial bacteria such promoted SCFAs, growth harmful microorganisms. Overall, could reshape restore imbalance inflammation alleviate development colitis, which may become novel dietary intervention.
Язык: Английский
