A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Pharmaceuticals, Год журнала: 2024, Номер 17(1), С. 124 - 124

Опубликована: Янв. 18, 2024

The extraction of bioactive compounds pharmaceutical interest from natural sources has been significantly explored in recent decades. However, the techniques used were not very efficient terms time and energy consumption; additionally, solvents for harmful environment. To improve environmental impact extractions at same increase yields, several new developed. Among most ones are ultrasound-assisted microwave-assisted extraction. These increased yield selectivity a smaller amount with decrease consumption. Nevertheless, high volume organic was still extraction, causing subsequent problem. Neoteric appeared as green alternatives to solvents. neoteric solvents, deep eutectic evidenced be one best due their intrinsic characteristics. considered because they made up such sugars, amino acids, carboxylic acids having low toxicity degradability. In addition, simple prepare, an atomic economy 100%, attractive physicochemical properties. Furthermore, huge number that can synthesize these make them useful since tailored selective towards specific component or class components. main aim this paper is give comprehensive review which describes properties, characteristics, production methods well its application extract interest. Additionally, overview more sustainable also given.

Язык: Английский

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Deep eutectic solvents as sustainable extraction media for extraction of polysaccharides from natural sources: Status, challenges and prospects

Carbohydrate Polymers, Год журнала: 2024, Номер 338, С. 122199 - 122199

Опубликована: Апрель 26, 2024

Язык: Английский

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Deep eutectic solvents as extraction media for food-derived biomacromolecules

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 171, С. 117521 - 117521

Опубликована: Янв. 3, 2024

Язык: Английский

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An eco-friendly extraction method to obtain pectin from passion fruit rinds (Passiflora edulis sp.) using subcritical water and pressurized natural deep eutectic solvents

Carbohydrate Polymers, Год журнала: 2023, Номер 326, С. 121578 - 121578

Опубликована: Ноя. 15, 2023

This work evaluated the efficiency of Subcritical Water Extraction (SWE) and Pressurized Natural Deep Eutectic Solvents (P-NaDESs) under different temperatures (100, 120, 140 160 °C) in obtaining pectin from Passion Fruit Rinds (PFR) its residual biomass (PFR - UAPLE), compare results with those Conventional (CE). The highest yields, 19.1 27.6 %, were achieved using P-NaDES (Citric Acid:Glucose:Water) at 120 °C for PFR PFR-UAPLE, respectively. Regarding Degree Esterification (DE), obtained SWE CE had DE below 50 while Acid: Glucose:Water), was above %. Higher Molecular Weights (MW) (98 81 kDa) compared to PFR-UAPLE CE. Galacturonic acid most abundant (74 78 %) monosaccharide by SWE. In terms morphology, water extraction provided more uniform textures, whereas acidified mixtures led heterogeneous surfaces. Overall, comparing P-NaDES, pectins differed monomeric composition, MW DE. These indicate that both methods can have applications depending on their structural characteristics.

Язык: Английский

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Structural properties and biological effects of pectic polysaccharides extracted from Tartary buckwheat sprouts by high pressure-assisted deep eutectic solvent extraction

LWT, Год журнала: 2024, Номер 203, С. 116397 - 116397

Опубликована: Июнь 24, 2024

Tartary buckwheat sprout is commonly consumed as salads and healthy vegetables, which rich in pectic polysaccharides. Nevertheless, the knowledge about polysaccharides extracted from sprouts (TBSP) are still limited. To facilitate potential applications of TBSP fortified ingredients or foods, impacts conventional hot water extraction (CHW), deep eutectic solvent (DES)-assisted (DEE), high pressure-assisted DES (HPDEE) on their structural biological properties were evaluated. Compared with CHW method, our findings revealed that both DEE HPDEE methods could obviously promoted yields regulated properties, resulting improvement functions. Especially, method decreased molecular mass, apparent viscosity, esterification degree TBSP, while notably increased uronic acids bound flavonoids. Indeed, remarkedly enhance antioxidant, anti-glycosylation, immunostimulatory activities probably via reducing its mass esterification, increasing free These reveal has good potentials for selectively extracting distinctive superior

Язык: Английский

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Switching from deep eutectic solvents to deep eutectic systems for natural product extraction

Green Chemical Engineering, Год журнала: 2024, Номер 6(1), С. 36 - 53

Опубликована: Июнь 1, 2024

This article presents a comprehensive overview of recent advancements in natural product extraction, focusing on the evolution from deep eutectic solvents (DESs) to systems (DESys) for extraction. DESs, known their environmentally friendly properties, have become crucial extracting various products plants, including micromolecules, lignin, and polysaccharides. Research into extraction mechanism reveals that target compounds typically form hydrogen bonds with effectively becoming part solvent system. insight has led development DESys method, where bond acceptors (HBAs) donors (HBDs) are directly mixed sample system containing compounds. The shift DES-based DESys-based introduces innovative approaches integral system, allowing one-step dissolution methodology eliminates need pre-prepared simplifying processes enhancing efficiency. Additionally, strategies DESs recycling reuse contribute sustainability efforts, offering cost-effective solutions. expanding applications cosmetics, food, industry, environmental fields highlight promising potential. By delineating transition products, this review offers valuable insights advancing practice green chemical engineering.

Язык: Английский

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Research on the Impact of Deep Eutectic Solvent and Hot-Water Extraction Methods on the Structure of Polygonatum sibiricum Polysaccharides

Molecules, Год журнала: 2023, Номер 28(19), С. 6981 - 6981

Опубликована: Окт. 8, 2023

Deep eutectic solvent (DES) and hot-water extraction (HWE) methods were utilized to extract polysaccharides from Polygonatum sibiricum, referred as DPsP WPsP, respectively. The extracted purified using the Superdex-200 dextran gel purification system, resulting in three components for each type of polysaccharide. structures these characterized. molecular weight analysis revealed that had slightly larger weights compared with DPsP-A showing a higher dispersity index broader distribution. main monosaccharide both WPsP mannose glucose, while exhibited greater variety sugar WPsP. FTIR demonstrated characteristic polysaccharide absorption peaks all six PSP components, predominance acidic pyranose sugars. NMR presence sugars, including rhamnose aldehyde acids, DPsP-B WPsP-A. primarily β-type glycosidic linkages, WPsP-A predominantly displayed α-type smaller fraction being β-type. These findings indicated differences composition structure between PSPs different methods. Overall, this study provided experimental evidence future research on structure–function relationship PSPs.

Язык: Английский

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Simultaneously efficient dissolution and structural modification of chrysanthemum pectin: Targeting at proliferation of Bacteroides

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 267, С. 131469 - 131469

Опубликована: Апрель 9, 2024

Язык: Английский

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Efficient and Selective Extraction of Rhamnogalacturonan-I-Enriched Pectic Polysaccharides from Tartary Buckwheat Leaves Using Deep-Eutectic-Solvent-Based Techniques

Foods, Год журнала: 2024, Номер 13(4), С. 625 - 625

Опубликована: Фев. 19, 2024

Tartary buckwheat green leaves are considered to be among the most important by-products in industry. Although abundant pectic polysaccharides, their potential applications food industry quite scarce. Therefore, promote as functional or fortified ingredients, both deep-eutectic-solvent-assisted extraction (DESE) and high-pressure-assisted deep eutectic solvent (HPDEE) were used efficiently selectively extract polysaccharides from (TBP). The results revealed that DESE HPDEE techniques not only improved efficiency of TBP but also regulated its structural properties beneficial effects. primary chemical structures extracted using different methods stable overall, mainly consisting homogalacturonan rhamnogalacturonan-I (RG-I) regions. However, could RG-I-enriched TBP, proportion RG-I region obviously improved. Additionally, improve antioxidant anti-glycosylation effects by increasing free uronic acids content bound polyphenolics reducing molecular weight. Moreover, partially intensify immunostimulatory effect region. These findings suggest DES-based techniques, especially method, can promising for efficient selective TBP.

Язык: Английский

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Highly Branched Rhamnogalacturonan-I Type Pectin from Wolfberry: Purification, Characterization, and Structure-Prebiotic/Immunomodulatory Activity Relationship

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(24), С. 14022 - 14034

Опубликована: Июнь 6, 2024

Due to the difficulty in obtaining highly branched rhamnogalacturonan-I (RG-I) type pectin, relationship between extent of RG-I branching (EB) pectin and prebiotic/immunomodulatory activity has not been systematically investigated. Moreover, it is only possible establish a structure–activity using that purified accurately characterized. In this study, homogeneous (LBP-P4, final product) with dual proliferative effects on Bifidobacterium macrophage was effectively for first time enzyme hydrolysis combined ultrafiltration. The content EB LBP-P4 reached 97.32 77.12, respectively. Its two branches were composed arabinan arabinogalactan-II, containing → 5)-Araf-(1→, →3)-Araf-(1→, →3,6)-Galp-(1→ →6)-Galp-(1→ residues). analysis indicated strong depended its high EB, which further confirmed by molecular docking simulation low/high β-1,6-galactosidase, α-l-arabinanase, Toll-like receptor 4 (TLR4).

Язык: Английский

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