Nanostructured Lipid Carrier-Filled Hydrogel Beads for the Delivery of Curcumin: Digestion, Intestinal Permeation, and Antioxidant Bioactivity After Gastrointestinal Digestion DOI Creative Commons
Rui Sun,

Chenyu Wei,

Xiaoyan Tang

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(5), С. 541 - 541

Опубликована: Апрель 22, 2025

Background/Objectives: The aim of the present study was to develop nanostructured lipid carrier (NLC)-filled hydrogel beads for delivery curcumin in functional foods. Methods: Curcumin-loaded NLC-filled based on calcium alginate were developed using extrusion method. Various preparation parameters, physicochemical characteristics, gastrointestinal fates, and antioxidant bioactivities studied confirm feasibility this system. Results: NLCs successfully filled into with an encapsulation efficiency above 80%. stability test displayed that encapsulated within further enhanced when beads. During vitro digestion, lipolysis rate matrix release adjusted by ex vivo intestinal permeation indicated from digestion products curcumin-loaded NLC-hydrogel beads, prepared appropriate concentrations (0.5% 1%), significantly compared NLCs. Furthermore, (1% alginate) exhibited bioactivity those Conclusions: This demonstrated might be a promising system hydrophobic bioactive compounds food systems.

Язык: Английский

Alginate-gelatin composite hydrogels for encapsulating Aloe vera extract; optimization, characterization, and release kinetics DOI Creative Commons

Shahrzad Ameli,

Moloud Nourani,

Nafiseh Bakhshi

и другие.

Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100717 - 100717

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Nanostructured Lipid Carrier-Filled Hydrogel Beads for the Delivery of Curcumin: Digestion, Intestinal Permeation, and Antioxidant Bioactivity After Gastrointestinal Digestion DOI Creative Commons
Rui Sun,

Chenyu Wei,

Xiaoyan Tang

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(5), С. 541 - 541

Опубликована: Апрель 22, 2025

Background/Objectives: The aim of the present study was to develop nanostructured lipid carrier (NLC)-filled hydrogel beads for delivery curcumin in functional foods. Methods: Curcumin-loaded NLC-filled based on calcium alginate were developed using extrusion method. Various preparation parameters, physicochemical characteristics, gastrointestinal fates, and antioxidant bioactivities studied confirm feasibility this system. Results: NLCs successfully filled into with an encapsulation efficiency above 80%. stability test displayed that encapsulated within further enhanced when beads. During vitro digestion, lipolysis rate matrix release adjusted by ex vivo intestinal permeation indicated from digestion products curcumin-loaded NLC-hydrogel beads, prepared appropriate concentrations (0.5% 1%), significantly compared NLCs. Furthermore, (1% alginate) exhibited bioactivity those Conclusions: This demonstrated might be a promising system hydrophobic bioactive compounds food systems.

Язык: Английский

Процитировано

0