Nanostructured Lipid Carrier-Filled Hydrogel Beads for the Delivery of Curcumin: Digestion, Intestinal Permeation, and Antioxidant Bioactivity After Gastrointestinal Digestion DOI Creative Commons
Rui Sun,

Chenyu Wei,

Xiaoyan Tang

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 541 - 541

Published: April 22, 2025

Background/Objectives: The aim of the present study was to develop nanostructured lipid carrier (NLC)-filled hydrogel beads for delivery curcumin in functional foods. Methods: Curcumin-loaded NLC-filled based on calcium alginate were developed using extrusion method. Various preparation parameters, physicochemical characteristics, gastrointestinal fates, and antioxidant bioactivities studied confirm feasibility this system. Results: NLCs successfully filled into with an encapsulation efficiency above 80%. stability test displayed that encapsulated within further enhanced when beads. During vitro digestion, lipolysis rate matrix release adjusted by ex vivo intestinal permeation indicated from digestion products curcumin-loaded NLC-hydrogel beads, prepared appropriate concentrations (0.5% 1%), significantly compared NLCs. Furthermore, (1% alginate) exhibited bioactivity those Conclusions: This demonstrated might be a promising system hydrophobic bioactive compounds food systems.

Language: Английский

Alginate-gelatin composite hydrogels for encapsulating Aloe vera extract; optimization, characterization, and release kinetics DOI Creative Commons

Shahrzad Ameli,

Moloud Nourani,

Nafiseh Bakhshi

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100717 - 100717

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nanostructured Lipid Carrier-Filled Hydrogel Beads for the Delivery of Curcumin: Digestion, Intestinal Permeation, and Antioxidant Bioactivity After Gastrointestinal Digestion DOI Creative Commons
Rui Sun,

Chenyu Wei,

Xiaoyan Tang

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 541 - 541

Published: April 22, 2025

Background/Objectives: The aim of the present study was to develop nanostructured lipid carrier (NLC)-filled hydrogel beads for delivery curcumin in functional foods. Methods: Curcumin-loaded NLC-filled based on calcium alginate were developed using extrusion method. Various preparation parameters, physicochemical characteristics, gastrointestinal fates, and antioxidant bioactivities studied confirm feasibility this system. Results: NLCs successfully filled into with an encapsulation efficiency above 80%. stability test displayed that encapsulated within further enhanced when beads. During vitro digestion, lipolysis rate matrix release adjusted by ex vivo intestinal permeation indicated from digestion products curcumin-loaded NLC-hydrogel beads, prepared appropriate concentrations (0.5% 1%), significantly compared NLCs. Furthermore, (1% alginate) exhibited bioactivity those Conclusions: This demonstrated might be a promising system hydrophobic bioactive compounds food systems.

Language: Английский

Citations

0