Abstract
Background
Mantle
cell
lymphoma
(MCL)
is
a
B-cell
non-Hodgkin’s
lymphoma.
Ferroptosis,
an
iron-dependent
programmed
death,
closely
related
to
cancer
prognosis.
In
this
study,
we
established
model
of
ferroptosis
genes
for
prognostic
evaluation
patients
with
MCL.
Methods
Using
the
single-cell
RNA
sequencing
datasets
GSE184031
and
mRNA
data
GSE32018
from
Gene
Expression
Omnibus,
identified
139
ferroptosis-related
in
Next
was
constructed
by
Cox
regression
Least
absolute
selection
shrinkage
Operator
analysis.
Finally,
used
CIBERSORT
analyze
immune
microenvironment
“oncoPredict”
package
predict
potential
drugs.
Results
our
model,
prognosis
MCL
assessed
risk
scoring
using
7
ANXA1,
IL1B,
YBX1,
CCND1,
MS4A1,
MFHAS1,
RILPL2.
The
were
divided
into
high-risk
low-risk
groups
based
on
had
inferior
overall
survival.
according
computational
drug
sensitivity
analysis,
four
small
molecule
compounds,
BMS-754807,
SB216763,
Doramapimod,
Trametinib,
as
therapeutic
agents
Conclusion
summary,
provide
gene
signature
This
study
provides
results
show
that
helps
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
166, С. 115415 - 115415
Опубликована: Сен. 4, 2023
Iron,
as
an
essential
trace
element
for
the
organism,
is
vital
maintaining
organism's
health.
Excessive
iron
can
promote
reactive
oxygen
species
(ROS)
accumulation,
thus
damaging
cells
and
tissues.
Ferroptosis
a
novel
form
of
programmed
cell
death
distinguished
by
overload
lipid
peroxidation,
which
unique
from
autophagy,
apoptosis
necrosis,
more
studies
are
focusing
on
ferroptosis.
Recent
evidence
suggests
that
ferroptosis
associated
with
development
female
reproductive
disorders
(FRDs),
including
polycystic
ovary
syndrome
(PCOS),
premature
ovarian
insufficiency
(POI),
endometriosis
(EMs),
cancer
(OC),
preeclampsia
(PE)
spontaneous
abortion
(SA).
Pathways
genes
may
participate
in
processes
regulate
granulosa
proliferation
secretion,
oocyte
development,
reserve
function,
early
embryonic
placental
oxidative
stress.
However,
its
exact
mechanism
has
not
been
fully
revealed.
Therefore,
our
review
systematically
elaborates
occurrence
research
progress
FRDs,
view
to
providing
literature
references
clinical
targeting
-related
pathways
regulatory
factors
management
FRDs.
Investigative Ophthalmology & Visual Science,
Год журнала:
2025,
Номер
66(1), С. 29 - 29
Опубликована: Янв. 13, 2025
Purpose:
To
investigate
potential
modes
of
programmed
cell
death
in
the
lens
epithelial
cells
(LECs)
patients
with
early
age-related
cortical
cataract
(ARCC)
and
to
explore
early-stage
intervention
strategies.
Methods:
Anterior
capsules
were
collected
from
ARCC
for
comprehensive
analysis.
Ultrastructural
examination
LECs
was
performed
using
transmission
electron
microscopy.
Cell
death–associated
protein
markers
quantified
via
Western
blot
analysis,
including
those
paraptosis
(ALIX,
GRP78),
apoptosis
(cleaved
caspase
3
9),
pyroptosis
(N-GSDMD),
ferroptosis
(GPX4).
Intracellular
vesicle–organelle
colocalization
assessed
through
immunofluorescence.
OGG1
expression
activity
evaluated
multiple
methods,
blot,
laser
micro-irradiation,
The
therapeutic
activator
TH10785
on
investigated
an
ex
vivo
rat
model.
Results:
Morphologic
changes
revealed
significant
endoplasmic
reticulum
(ER)
swelling
patient
LECs,
no
characteristic
apoptotic
features.
Paraptosis-related
proteins
exhibited
alterations,
while
other
pathway
(apoptosis,
pyroptosis,
ferroptosis)
remained
unchanged.
In
reactive
oxygen
species–induced
model,
vesicular
structures
showed
exclusive
ER-specific
fluorescence.
Elevated
levels
DNA
damage
marker
7,8-dihydro-8-oxoguanine
observed
concurrent
decreased
activity.
efficacy
suppressing
cultures.
Conclusions:
Paraptosis
identified
ARCC.
activates
suppress
suggesting
a
novel
approach
intervention.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Фев. 6, 2024
Abstract
Iron
metabolism
disorders
are
implicated
in
the
pathogenesis
of
Alzheimer’s
disease
(AD).
It
was
previously
reported
that
transferrin
receptor
(TFR1)
expression
upregulated
AD
mouse
model.
However,
precise
biological
functions
TFR1
progression
remains
unclear.
Herein,
we
observed
a
gradual
increase
protein
during
differentiation
patient-derived
induced
pluripotent
stem
cells
(AD-iPS).
knockdown
inhibited
ferritin
and
heavy
chain
1
(FTH1),
enhanced
ferroportin
(FPN1),
decreased
intracellular
levels
total
iron,
labile
reactive
oxygen
species
(ROS).
Moreover,
improved
mitochondrial
membrane
potential
(MMP),
increased
adenosine
triphosphate
(ATP)
content,
downregulated
fission
proteins,
fusion
proteins.
alleviated
iron
overload
dysfunction
neural
differentiated
from
AD-iPS,
while
overexpression
showed
opposite
results.
Additionally,
TFR1interacted
with
glycogen
synthase
kinase
3
beta
(GSK3B)
promoted
GSK3B
expression.
reversed
inhibitory
effects
on
AD-iPS
cells.
In
conclusion,
by
promoting
Our
findings
provide
therapeutic
target
for
treatment
AD.
Graphical
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 27, 2024
Ferroptosis,
a
new
type
of
programmed
cell
death
proposed
in
recent
years,
is
characterized
mainly
by
reactive
oxygen
species
and
iron-mediated
lipid
peroxidation
differs
from
death,
such
as
apoptosis,
necrosis,
autophagy.
Ferroptosis
associated
with
variety
physiological
pathophysiological
processes.
Recent
studies
have
shown
that
ferroptosis
can
aggravate
or
reduce
the
occurrence
development
diseases
targeting
metabolic
pathways
signaling
tumors,
ischemic
organ
damage,
other
degenerative
related
to
peroxidation.
Increasing
evidence
suggests
closely
linked
onset
progression
various
ophthalmic
conditions,
including
corneal
injury,
glaucoma,
age-related
macular
degeneration,
diabetic
retinopathy,
retinal
detachment,
retinoblastoma.
Our
review
current
research
on
reveals
significant
advancements
our
understanding
pathogenesis,
aetiology,
treatment
these
conditions.
Abstract
Traditional
ophthalmic
formulations
are
characterized
by
low
bioavailability,
short
intraocular
retention
time,
strong
irritation,
and
failure
to
achieve
the
expected
therapeutic
effect
due
special
physiological
structure
of
eye
existence
many
barriers.
Microneedle
drug
delivery
is
a
novel
transdermal
modality.
Responsive
microneedles
defined
as
controllably
releasing
payloads
in
response
stimuli,
including
pH
levels,
temperature,
enzymes,
reactive
oxygen
species
(ROS),
well
external
stimuli
such
magnetic
fields
light.
In
addition
inheriting
advantages
traditional
microneedles,
which
include
enhanced
targeting
permeability,
non‐invasiveness,
painless
application,
integration
with
stimulus‐responsive
materials
enables
responsive
personalized
precision
process,
further
increases
accuracy
efficiency
ocular
treatments,
making
on‐demand
possible.
This
article
systematically
reviews
classification,
mechanisms,
characteristics
provides
detailed
introduction
their
diagnostic
applications
real‐time
monitoring
potential
diseases,
aiming
offer
insights
for
treatment
diseases
future.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 307 - 307
Опубликована: Янв. 1, 2025
Cataracts
remain
the
leading
cause
of
visual
impairment
worldwide,
yet
underlying
molecular
mechanisms,
particularly
in
age-related
cataracts
(ARCs),
are
not
fully
understood.
The
Notch
signaling
pathway,
known
for
its
critical
role
various
degenerative
diseases,
may
also
contribute
to
ARC
pathogenesis,
although
specific
involvement
is
unclear.
This
study
investigates
regulating
ferroptosis
lens
epithelial
cells
(LECs)
and
impact
on
progression.
RNA
sequencing
anterior
capsule
samples
from
patients
revealed
a
significant
downregulation
signaling,
coupled
with
an
upregulation
ferroptosis-related
genes.
Notch1
expression
decreased,
while
markers
increased
age-dependent
manner.
In
vitro,
alleviated
by
decreasing
ferritin
heavy
chain
1
(FTH1)
p53
levels
enhancing
nuclear
factor
erythroid
2-related
2
(Nrf2),
glutathione
peroxidase
4
(GPX4),
solute
carrier
family
7
member
11
(SLC7A11).
Conversely,
inhibition
exacerbated
ferroptosis,
as
evidenced
reduced
Nrf2,
GPX4,
SLC7A11
expression.
These
findings
suggest
that
promotes
LECs
impairing
Nrf2/GPX4
antioxidant
thereby
contributing
development.
offers
new
insights
into
pathogenesis
highlights
pathway
potential
therapeutic
target
preventing
or
mitigating
Cell Death and Disease,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 3, 2025
Abstract
Highly
myopic
cataract
(HMC)
is
a
leading
cause
of
blindness
among
the
working-age
individuals,
with
its
pathogenesis
poorly
understood.
This
study
aimed
to
elucidate
role
ferroptosis
in
HMC
development
as
well
underlying
mechanisms.
In
lens
epithelia,
levels
Fe
2+
and
lipid
peroxidation
were
found
elevated,
increased
vulnerability
towards
revealed
by
transmission
electron
microscopy.
Mechanistically,
RNA
sequencing
epithelial
samples
identified
up-regulated
expression
discoidin
domain
receptor
tyrosine
kinase
2
(DDR2)
key
factor,
which
could
enhance
sensitivity
via
Src-Hippo
pathway.
Specifically,
DDR2
interacted
Src
kinase,
nuclear
translocation
homologous
transcriptional
regulators
(yes-associated
protein
1
[YAP1]
WW
containing
transcription
regulator
[WWTR1])
Hippo
pathway,
altered
level
ferroptosis-related
genes.
Notably,
highly
eyes
mice
exhibited
higher
RSL3,
inducer,
manifested
more
severe
opacities
both
vitro
vivo
compared
contralateral
control
eyes,
be
alleviated
inhibitors
either
or
DDR2.
Altogether,
these
findings
highlighted
mediating
formation,
providing
novel
insight
for
therapeutic
interventions.
