Impact of plant-derived antioxidants on heart aging: a mechanistic outlook

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 21, 2025

Heart aging involves a complex interplay of genetic and environmental influences, leading to gradual deterioration cardiovascular integrity function. Age-related physiological changes, including ventricular hypertrophy, diastolic dysfunction, myocardial fibrosis, increased arterial stiffness, endothelial are influenced by key mechanisms like autophagy, inflammation, oxidative stress. This review aims explore the therapeutic potential plant-derived bioactive antioxidants in mitigating heart aging. These compounds, often rich polyphenols, flavonoids, other phytochemicals, exhibit notable antioxidant, anti-inflammatory, cardioprotective properties. substances have intricate properties, ability scavenge ROS, enhance endogenous antioxidant defenses, regulate signaling pathways, impede fibrosis inflammation-promoting processes. By focusing on molecular linked cardiac aging, produced from plants provide significant promise reduce age-related decline improve general health. Through comprehensive analysis preclinical clinical studies, this work highlights associated with promising effects antioxidants. The findings may helpful for researchers identifying specific molecules preventive heart.

Язык: Английский

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Overview of Injectable Hydrogels for the Treatment of Myocardial Infarction

Cardiovascular Innovations and Applications, Год журнала: 2024, Номер 9(1)

Опубликована: Янв. 1, 2024

Myocardial infarction (MI) triggers adverse remodeling mechanisms, thus leading to heart failure. Since the application of biomaterial-based scaffolds emerged as a viable approach for providing mechanical support and promoting cell growth, injectable hydrogels have garnered substantial attention in MI treatment because their minimally invasive administration through injection diminished risk infection. To fully understand interplay between infarcted myocardium repair, this review provides an overview recent advances hydrogel-mediated therapy, including: I) material designs repairing myocardium, considering pathophysiological mechanism design principles biomaterials treatment; II) development functional treatment, including conductive, self-healing, drug-loaded, stimulus-responsive hydrogels; III) research progress using restore cardiac function by neovascularization, enhancing cardiomyocyte proliferation, decreasing myocardial fibrosis, inhibiting excessive inflammation. Overall, presents current state hydrogel offering valuable information facilitate interdisciplinary knowledge transfer enable prognostic markers suitable materials.

Язык: Английский

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Ferrostatin-1 specifically targets mitochondrial iron-sulfur clusters and aconitase to improve cardiac function in Sirtuin 3 cardiomyocyte knockout mice

Journal of Molecular and Cellular Cardiology, Год журнала: 2024, Номер 192, С. 36 - 47

Опубликована: Май 9, 2024

Язык: Английский

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Mechanisms involved in the regulation of mitochondrial quality control by PGAM5 in heart failure

Cell Stress and Chaperones, Год журнала: 2024, Номер 29(3), С. 510 - 518

Опубликована: Май 29, 2024

Heart failure refers to a group of clinical syndromes in which various heart diseases lead the inability cardiac output meet metabolic needs body's tissues. Cardiac metabolism requires enormous amounts energy; thus, impaired myocardial energy is considered key factor occurrence and development failure. Mitochondria serve as primary source for cardiomyocytes, their regular functionality underpins healthy function. The mitochondrial quality control system crucial mechanism regulating any abnormality this can potentially impact morphology structure mitochondria, well cardiomyocytes. PGAM5, multifunctional protein, plays role regulation through multiple pathways. Therefore, abnormal PGAM5 function closely related damage. This article reviews PGAM5's involvement failure, thereby providing theoretical basis future in-depth research.

Язык: Английский

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Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications

Heliyon, Год журнала: 2024, Номер 10(13), С. e33309 - e33309

Опубликована: Июнь 21, 2024

Cardiovascular diseases (CVDs) are one of the most significant that pose a threat to human health. The innovative traditional Chinese medicine Tongxinluo Capsule, developed under guidance theory medicine, has good clinical efficacy in various cardiovascular diseases, this effects such as blood protection, vascular myocardial stabilizing vulnerable plaques, and vasodilation. However, CVDs multifactorial disease, their underlying mechanisms not fully understood. Therefore, exploring mechanism action application Capsule treatment is beneficial for exerting its therapeutic effect from multiple components, targets, pathways. At same time, it provides broader ideas other difficult treat event chain, theoretical significance improving with medicine.

Язык: Английский

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Interplay of Ferroptosis, Cuproptosis, and PANoptosis in Cancer Treatment-Induced Cardiotoxicity: Mechanisms and Therapeutic Implications

Seminars in Cancer Biology, Год журнала: 2024, Номер 106-107, С. 106 - 122

Опубликована: Сен. 17, 2024

Язык: Английский

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The mitochondrial link: Phthalate exposure and cardiovascular disease

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Год журнала: 2024, Номер 1871(4), С. 119708 - 119708

Опубликована: Март 19, 2024

Язык: Английский

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A thermo-sensitive hydrogel with prominent hemostatic effect prevents tumor recurrence via anti-anoikis-resistance

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 20, 2024

Tumor cells can survive when detached from the extracellular matrix (ECM) or lose cell-cell connections, a phenomenon known as anoikis-resistance (AR). AR is closely associated with tumor cell metastasis and recurrence, enabling to disseminate, migrate, invade after detachment. To address this issue, novel intervention method combining intraoperative hemostasis multifunctional nanozyme driven-enhanced chemodynamic therapy (ECDT) has been proposed, which holds potential weaken capability of suppress recurrence. Here, nanocomposite containing dendritic mesoporous nanoframework Cu

Язык: Английский

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Unique Interactions of the Small Translocases of the Mitochondrial Inner Membrane (Tims) in Trypanosoma brucei

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1415 - 1415

Опубликована: Янв. 24, 2024

The infectious agent for African trypanosomiasis, Trypanosoma brucei, possesses a unique and essential translocase of the mitochondrial inner membrane, known as TbTIM17 complex. TbTim17 associates with six small TbTims (TbTim9, TbTim10, TbTim11, TbTim12, TbTim13, TbTim8/13). However, interaction patterns these smaller each other are not clear. Through yeast two-hybrid (Y2H) co-immunoprecipitation analyses, we demonstrate that all interact other. Stronger interactions were found among TbTim8/13, TbTim9, TbTim10. TbTim10 shows weaker associations which has stronger connection TbTim17. Each also interacts strongly C-terminal region RNAi studies indicated TbTims, TbTim13 is most crucial maintaining steady-state levels Further analysis TbTim complexes by size exclusion chromatography revealed TbTim, except present in ~70 kDa complexes, possibly existing heterohexameric forms. In contrast, primarily larger complex (>800 kDa) co-fractionates Altogether, our results that, relative to eukaryotes, architecture function specific T. brucei.

Язык: Английский

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Validamycin A Inhibited FB₁ Biosynthesis by the Target FvNth in Fusarium verticillioides

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(28), С. 15487 - 15497

Опубликована: Июнь 25, 2024

Validamycin A (VMA) is an antifungal antibiotic derived from

Язык: Английский

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