Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(13), С. 3885 - 3885
Опубликована: Июль 2, 2024
Background:
The
intestinal
microbiota
can
regulate
numerous
host
functions,
including
the
immune
response.
Through
fermentation,
produces
and
releases
microbial
metabolites
such
as
short-chain
fatty
acids
(SCFAs),
which
affect
homeostasis.
There
is
growing
evidence
that
gut
microbiome
have
a
major
impact
on
cancer.
Specific
composition
are
associated
with
tumor
status
in
host.
However,
their
effects
antitumor
response
scarcely
been
investigated.
Natural
killer
(NK)
cells
play
an
important
role
immunity
due
to
ability
directly
identify
eliminate
cells.
Methods:
aim
of
this
study
was
investigate
SCFAs
antitumoral
NK
cell
activity,
using
NK-92
line.
Results:
Here,
we
describe
how
boost
activity.
induced
release
extracellular
vesicles
reduced
secretion
anti-inflammatory
cytokine
IL-10.
also
increased
cytotoxicity
against
multiple
myeloma
Conclusions:
Our
results
indicate,
for
first
time,
enormous
potential
regulating
defense,
where
modulation
SCFAs’
production
could
fundamental
cancer
immunotherapy.
Phytomedicine,
Год журнала:
2024,
Номер
128, С. 155530 - 155530
Опубликована: Март 11, 2024
Ischemic
stroke
(IS)
ranks
as
the
second
common
cause
of
death
worldwide.
However,
a
narrow
thrombolysis
timeframe
and
ischemia-reperfusion
(I/R)
injury
limits
patient
recovery.
Moreover,
anticoagulation
antithrombotic
drugs
do
not
meet
clinical
requirements.
Studies
have
demonstrated
close
communication
between
brain
gut
microbiota
in
IS.
Notoginsenoside
R1
(NG-R1),
significant
component
total
saponins
from
Panax
notoginseng,
has
been
to
be
effective
against
cerebral
I/R
injury.
Total
used
treat
IS
Chinese
pharmacopoeia.
Furthermore,
previous
research
indicated
that
absorption
NG-R1
was
controlled
by
microbiota.
This
study
aimed
access
impact
treatment
on
neuroinflammation
investigate
microbiota-related
mechanisms.
significantly
reduced
neuronal
middle
artery
occlusion/reperfusion
(MCAO/R)
models.
16S
rRNA
sequencing
revealed
displayed
reversal
related
with
MCAO/R
Additionally,
administration
attenuates
intestinal
inflammation,
barrier
destruction,
systemic
inflammation.
transplantation
exhibited
similar
effect
In
summary,
resulted
restoration
structure
blood-brain
(BBB)
reduction
via
suppressing
stimulation
astrocytes
microglia
ischemic
area.
Mechanistic
suppressed
toll-like
receptor
4/myeloid
differentiation
primary
response
88/nuclear
factor
kappa
B
(TLR4/MyD88/NF-κB)
signaling
pathway
both
colon.
enhanced
dysbiosis
inhibiting
TLR4
protect
These
findings
elucidate
mechanisms
which
improve
outcomes
provide
some
basis
for
notoginseng
treatment.
Frontiers in Oncology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 20, 2025
Acute
myeloid
leukemia
(AML)
is
an
aggressive
hematological
malignancy;
it
the
most
common
acute
in
adults.
AML
prognosis
often
poor,
and
relapse
occurs
after
initial
remission.
Recurrent
genetic
abnormalities
underlying
this
disease
presence
of
leukemic
stem
cells
complicate
treatment.
However,
complex
metabolic
reprogramming
that
enables
unrestrained
cell
growth
seen
these
may
also
be
their
Achilles’
heel.
In
cells,
mitophagy
operates
as
a
double-edged
sword.
On
one
hand,
provides
source
building
blocks
for
further
division
serves
method
removing
damaged
organelles,
promoting
survival.
profound
changes
to
mitochondria
render
organelles
more
sensitive
damage
place
them
precariously
close
excess
mitophagic
activation.
This
review
discusses
dual
role
plays
survival,
importance
targeting
treat
AML,
current
progress
area.
The
discovery
mechanism
action
multiple
compounds
were
used
inhibit
or
stimulate
effects
on
survival
are
described.
Further,
we
explore
combination
strategy
mitophagy-targeting
with
existing
and/or
novel
chemotherapeutics
eradicate
discuss
strategies
uncover
new
drug
targets
mitochondria-targeting
drugs.
Journal of Cellular Physiology,
Год журнала:
2025,
Номер
240(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Fatty
acids
are
essential
biomolecules
that
support
several
cellular
processes,
such
as
membrane
structures,
energy
storage
and
production,
well
signal
transduction.
Accordingly,
changes
in
fatty
acid
metabolism
can
have
a
significant
impact
on
cell
behavior,
growth,
survival,
proliferation,
differentiation,
motility.
Therefore,
it
is
not
surprising
many
aspects
of
frequently
dysregulated
human
cancer,
including
highly
aggressive
blood
cancers
acute
leukemia.
The
aims
this
review
to
summarize
the
specifically
coopted
leukemia
current
preclinical
strategies
for
targeting
these
cancers.
Fermentation,
Год журнала:
2025,
Номер
11(3), С. 132 - 132
Опубликована: Март 8, 2025
Efficient
farm
practices
are
crucial
for
livestock
health
and
performance,
cold
stress
is
a
major
challenge
cattle
in
winter.
This
study
aimed
to
preliminarily
investigate
the
effects
of
warm
water
intake
winter
on
growth
thermal
indicators,
serum
hormones
metabolites,
rumen
fermentation
parameters,
fiber
degrading
enzyme,
microflora
yellow
during
Eight
Wandong
Bulls
(Bos
taurus)
were
divided
into
two
groups:
group
C,
which
received
(6.36
±
1.99
°C),
E,
(32.00
3.12
°C)
30
d.
The
results
showed
that
significantly
increased
ADG
(p
=
0.024)
DMI
0.046)
decreased
0.047)
ratio
feed
weight
gain.
Furthermore,
heat
production,
respiratory
rate,
surface
temperature,
rectal
temperature
did
not
alter
with
but
production
value
bulls
(29.64
vs.
25.76
MJ/W0.75
h−1)
compared
water.
concentrations
thyroxine
0.021),
urea
nitrogen
0.025),
glucose
0.011)
drinking
those
NH3-N
0.048),
total
VFA
0.010),
acetate
0.009),
propionate
cellulase
<
0.01),
xylanase
0.05)
lower
C
E.
Total
bacterial
abundance,
as
well
specific
species
including
Ruminococcus
flavus,
albus,
Prevotella
ruminicola,
In
conclusion,
enhanced
performance
by
influencing
energy
metabolism,
regulating
modulating
ruminal
intake.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 17, 2025
Bone
remodeling
is
a
dynamic
and
continuous
process
involving
three
components:
bone
formation
mediated
by
osteoblasts,
resorption
osteoclasts,
formation-resorption
balancing
regulated
osteocytes.
Excessive
osteocyte
death
found
in
various
diseases,
such
as
postmenopausal
osteoporosis
(PMOP),
osteoclasts
are
increased
activated
at
sites.
Currently,
apart
from
apoptosis
necrosis
previously
established,
more
forms
of
cell
reported,
including
necroptosis,
ferroptosis
pyroptosis.
These
play
important
role
the
development
inflammatory
diseases
diseases.
Increasing
studies
have
revealed
that
promote
osteoclast
via
different
mechanism,
actively
secreting
pro-inflammatory
pro-osteoclastogenic
cytokines,
tumor
factor
alpha
(TNF-α)
receptor
activator
nuclear
factor-kappa
B
ligand
(RANKL),
or
passively
releasing
damage
associated
molecule
patterns
(DAMPs),
high
mobility
group
box
1
(HMGB1).
This
review
summarizes
established
potential
mechanisms
which
regulate
formation,
aiming
to
provide
better
understanding
disease
therapeutic
target.
