Foods,
Год журнала:
2024,
Номер
13(22), С. 3672 - 3672
Опубликована: Ноя. 18, 2024
Hyperlipidemia,
characterized
by
an
abnormal
lipid
metabolism,
is
related
to
multiple
cardiovascular
diseases
that
pose
challenges
global
public
health.
Macadamia
oil
(MO),
rich
in
monounsaturated
fatty
acids
(around
80%),
regarded
as
a
functional
used
regulate
accumulation.
Nonetheless,
the
lipid-lowering
mechanism
of
MO
still
unknown.
Therefore,
effects
high-fat
diet
(HFD)-induced
hyperlipidemic
mice
were
evaluated
this
study.
The
results
revealed
could
effectively
reduce
body
weight
and
organ
index
improve
serum
levels
reducing
total
cholesterol,
triglycerides,
low-density
lipoprotein
cholesterol
elevating
high-density
levels.
Additionally,
supplementation
liver
function
caused
hyperlipemia,
decreased
enzyme
levels,
including
alanine
aminotransferase
aspartate
aminotransferase.
Meanwhile,
also
exhibited
inhibitory
effect
on
oxidative
stress
accumulation
HFD.
Moreover,
findings
from
qRT-PCR
Western
blotting
analyses
suggest
markedly
prevented
hyperlipidemia
inhibiting
expression
AMPK
pathway-related
genes,
SREBP-1c,
FAS,
ACC,
PPAR-γ,
well
upregulating
Nrf2,
HO-1,
γ-GCS.
These
indicate
attenuates
vivo
via
AMPK/Nrf2
pathway
activation,
suggesting
serve
dietary
or
medication
for
treating
hyperlipidemia.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1521 - 1521
Опубликована: Фев. 11, 2025
Pyranoanthocyanins
exhibit
greater
bioactivity
compared
to
monomeric
anthocyanins,
yet
the
lipid-lowering
effects
of
pyranoanthocyanin
Vitisin
A,
a
primary
derivative
found
in
aged
red
wines,
have
not
been
extensively
studied
vivo.
This
study
evaluated
triglyceride-lowering
A
and
its
anthocyanin
counterpart
Cyanidin-3-O-glucoside
(C3G)
both
free
fatty
acid
-induced
HepG2
cells
high-fat
diet-fed
ApoE-/-
mice,
with
focus
on
their
roles
lipid
metabolism.
In
vitro,
significantly
reduced
triglyceride
levels
accumulation
C3G
at
equivalent
concentrate.
vivo,
dietary
supplementation
100
mg/kg
body
weight
gain
plasma
by
19.6%
29.5%,
respectively,
whereas
no
significant
were
observed
C3G.
Mechanistically,
markedly
inhibited
hepatic
de
novo
lipogenesis
(DNL)
activating
AMPK/ACC
signaling
pathway
downregulating
FASN
expression.
Concurrently,
enhanced
β-oxidation
more
robustly
than
upregulating
CPT-1A
via
AMPK/SIRT1/PGC-1α
PPAR-α/PGC-1α
pathways.
Both
driving
peroxisomal
very-long-chain
acids.
summary,
demonstrated
superior
C3G,
primarily
through
dual
mechanisms
inhibiting
DNL
enhancing
β-oxidation.
Journal of the Science of Food and Agriculture,
Год журнала:
2024,
Номер
104(9), С. 5089 - 5103
Опубликована: Янв. 30, 2024
Obesity
is
closely
associated
with
lipid
accumulation,
inflammation
and
intestinal
microbiota
dysbiosis.
Short-
long-chain
type
structured
lipids
(SLCTs)
are
kinds
of
low-calorie
demonstrate
anti-obesity
hypolipidemia
bioactivity.
The
objective
this
study
to
investigate
the
potential
effects
dietary
supplementation
SLCTs
rich
in
short-chain
fatty
acids
polyunsaturated
on
high-fat-diet-induced
obesity
gut
modulation
C57BL/6J
mice.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(42), С. 23211 - 23223
Опубликована: Окт. 11, 2024
Gut
microbiota
provides
an
important
insight
into
clarifying
the
mechanism
of
active
substances
with
low
bioavailability,
but
its
specific
action
varied
case
by
and
remained
unclear.
Dihydroquercetin
(DHQ)
is
a
bioactive
flavonoid
which
showed
beneficial
effects
on
colitis
alleviation
gut
modulation.
Herein,
we
aimed
to
explore
microbiota-dependent
anticolitis
DHQ
in
sight
metabolites
their
interactions
microRNAs
(miRNAs).
Dietary
supplementation
alleviated
dextran
sulfate
sodium-induced
phenotypes
improved
dysbiosis.
Fecal
transplantation
further
revealed
that
activity
was
mediated
microbiota.
To
clarify
how
modulated
mice,
tandem
analyses
microbiome
targeted
metabolome
were
performed,
altered
profiles
metabolite
short-chain
fatty
acids
(SCFAs)
bile
producers
observed
DHQ-treated
mice.
In
addition,
SCFA
treatment
compared
acids,
along
inhibition
phosphoinositide-3-kinase
(PI3K)-protein
kinase
B
(Akt)
pathway.
Subsequently,
colonic
miRNA
profile
mice
receiving
sequenced,
differentially
expressed
miR-10a-5p
identified.
Both
prediction
analysis
dual-luciferase
reporter
assay
indicated
directly
bind
3'-untranslated
regions
gene
Critical Reviews in Analytical Chemistry,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Фев. 13, 2025
Microbiomes
significantly
impact
food
flavor,
quality
and
human
health.
The
development
of
omics
technologies
has
revolutionized
our
understanding
the
microbiome,
generated
complex
datasets,
as
well
their
processing
interpretation
need
to
be
taken
seriously.
Currently,
chemometrics
shown
huge
potential
in
data
analysis,
which
is
crucial
reveal
functional
attributes
mechanisms
microbiomes
nutrition
safety.
However,
various
chemometric
tools
have
own
characteristics,
selecting
appropriate
performing
multiomics
fusion
analysis
improve
precision
reliability
microbial
investigations
still
a
challenge.
In
this
review,
we
summarized
used
microbiome
studies,
overviewed
principle
applicability
omics,
discussed
challenges
prospects
chemometrics.
urgent
for
integrate
deep
learning
(DL)
artificial
intelligence
algorithms
enhance
its
analytical
capabilities
prediction
accuracy.
We
hope
review
will
provide
valuable
insights
integration
bioinformatics
combined
with
techniques
investigation.
future,
modern
further
deepen
microbiology
