Toxicity of TPhP on the gills and intestines of zebrafish from the perspectives of histopathology, oxidative stress and immune response

The Science of The Total Environment, Год журнала: 2023, Номер 908, С. 168212 - 168212

Опубликована: Окт. 31, 2023

Язык: Английский

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Ferritinophagy Is Critical for Deoxynivalenol-Induced Liver Injury in Mice

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(12), С. 6660 - 6671

Опубликована: Март 19, 2024

Background: Deoxynivalenol (DON) contamination, pervasive throughout all stages of food production and processing, presents a significant threat to human health. The degradation ferritin mediated by nuclear receptor coactivator 4 (NCOA4), termed ferritinophagy, plays crucial role in maintaining iron homeostasis regulating ferroptosis. Aim: This study aims elucidate the ferritinophagy ferroptosis DON-induced liver injury. Methods: Male mice AML12 cells were subjected varying doses DON, serving as vivo vitro models, respectively. Protein expression was assessed using immunofluorescence western blot techniques. Co-immunoprecipitation employed investigate protein–protein interactions. Results: Our findings demonstrate that DON triggers hepatocyte ferritinophagy-dependent manner. Specifically, impedes activation mammalian target rapamycin complex 1 (mTORC1) inhibiting RAC1's binding mTOR, thereby ultimately inducing autophagy. Concurrently, amplifies NCOA4's affinity for facilitating NCOA4 phosphorylation through ataxia-telangiectasia mutated kinase (ATM), thus promoting autophagy-dependent ferritin. Both autophagy inhibition suppression ameliorate Conclusion: concludes facilitates NCOA4-mediated via ATM–NCOA4 pathway, subsequently liver.

Язык: Английский

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Low-dose deoxynivalenol exposure inhibits hepatic mitophagy and hesperidin reverses this phenomenon by activating SIRT1

Journal of Hazardous Materials, Год журнала: 2024, Номер 468, С. 133854 - 133854

Опубликована: Фев. 22, 2024

Язык: Английский

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18beta-glycyrrhetinic acid alleviates deoxynivalenol-induced hepatotoxicity by inhibiting GPX4-dependent ferroptosis

Toxicon, Год журнала: 2025, Номер unknown, С. 108228 - 108228

Опубликована: Янв. 1, 2025

Язык: Английский

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Induction of autophagy via the ROS-dependent AMPK/mTOR pathway protects deoxynivalenol exposure grass carp hepatocytes damage

Fish & Shellfish Immunology, Год журнала: 2023, Номер 135, С. 108687 - 108687

Опубликована: Март 13, 2023

Язык: Английский

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Natural Phenolic Compounds against Trichothecenes: From Protective Mechanisms to Future Perspectives

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Trichothecenes (TCNs), Fusarium-derived mycotoxins exemplified by deoxynivalenol and T-2 toxin, threaten global health through multisystem toxicity widespread contamination. Natural phenolic compounds (NPCs), leveraging their intrinsic safety natural abundance, demonstrate multimechanistic efficacy in counteracting TCN toxicity. This article reviews both domestic international research on the protective mechanisms of NPCs against TCN-induced exert effects multitiered mechanisms: (1) molecular regulation via Nrf2-centric antioxidant activation MAPK/NF-κB inflammatory axis suppression, coupled with coordinated inhibition programmed cell death pathways (apoptosis/ferroptosis/pyroptosis) autophagy modulation, where GPX4 emerges as a critical ferroptosis regulator; (2) restoring microbiome balance, enhancing intestinal barrier function, optimizing nutrient transport. Gut microflora may also serve an additional target for mitigating TCNs. further inhibit Fusarium proliferation mycotoxin biosynthesis. While there is demonstrated potential food sustainable feed development, challenges persist bioavailability optimization, pharmacokinetic profiling, microbiota-metabolite crosstalk. analysis advances NPC-based strategies detoxification agriculture.

Язык: Английский

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Recalling the reported toxicity assessment of deoxynivalenol, mitigating strategies and its toxicity mechanisms: Comprehensive review

Chemico-Biological Interactions, Год журнала: 2023, Номер 387, С. 110799 - 110799

Опубликована: Ноя. 14, 2023

Язык: Английский

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Effect of flavanone rich lemon peel extract on feed intake and growth of Labeo rohita (Hamilton, 1822) fingerlings reared at low temperature recirculatory aquaculture system

Aquaculture, Год журнала: 2023, Номер 584, С. 740450 - 740450

Опубликована: Дек. 7, 2023

Язык: Английский

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Compound probiotics and glycyrrhizic acid alleviate DON-induced liver damage linked to the alteration of lipid metabolism in piglets

Journal of Functional Foods, Год журнала: 2024, Номер 120, С. 106390 - 106390

Опубликована: Авг. 6, 2024

Язык: Английский

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