
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Окт. 14, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Окт. 14, 2024
Язык: Английский
Archives of Toxicology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
2The Science of The Total Environment, Год журнала: 2024, Номер 952, С. 175875 - 175875
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
8Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(25), С. 14349 - 14363
Опубликована: Июнь 13, 2024
Deoxynivalenol (DON) is a common agricultural mycotoxin that chemically stable and not easily removed from cereal foods. When organisms consume food made contaminated crops, it can be hazardous to their health. Numerous studies in recent years have found hesperidin (HDN) has hepatoprotective effects on wide range of toxins. However, few scholars explored the potential HDN attenuating DON-induced liver injury. In this study, we established low-dose DON exposure model intervened with three doses HDN, acting male C57 BL/6 mice AML12 cells, which served as vivo vitro models, respectively, investigate protective mechanism against exposure-induced The results suggested disrupted hepatic autophagic fluxes, thereby impairing structure function, significantly attenuated these changes. Further revealed alleviated excessive autophagy through mTOR pathway lysosomal dysfunction AKT/GSK3β/TFEB pathway. Overall, our study could ameliorate flux disorders via pathway, reducing
Язык: Английский
Процитировано
7Toxicon, Год журнала: 2025, Номер unknown, С. 108228 - 108228
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Фев. 25, 2025
Ferritinophagy, the selective autophagic degradation of ferritin to release iron, is emerging as a critical regulator iron homeostasis and key player in pathogenesis various liver diseases. This review comprehensively examines mechanisms, regulation, multifaceted roles ferritinophagy health disease. Ferritinophagy intricately regulated by several factors, including Nuclear Receptor Coactivator 4 (NCOA4), Iron regulatory proteins signaling pathways such mTOR AMPK. These mechanisms ensure proper utilization prevent overload, which can induce oxidative stress ferroptosis. In diseases, exhibits dual roles. fibrosis, promoting hepatic stellate cells (HSCs) cell senescence reduce fibrosis progression. However, non-alcoholic fatty disease (NAFLD), chronic may exacerbate injury through overload stress. hepatocellular carcinoma (HCC), be harnessed novel therapeutic strategy inducing ferroptosis cancer cells. Additionally, implicated drug-induced sepsis-associated damage, highlighting its broad impact on pathology. also explores crosstalk between other autophagy pathways, mitophagy lipophagy, collectively influence cellular Understanding these interactions essential for developing comprehensive strategies targeting multiple pathways. summary, complex dynamic process with significant implications provides an in-depth analysis ferritinophagy's potential target, emphasizing need further research elucidate role
Язык: Английский
Процитировано
1Heliyon, Год журнала: 2024, Номер 10(7), С. e28865 - e28865
Опубликована: Март 29, 2024
Inhibition of activated hepatic stellate cells (HSCs) is a promising approach for treating liver fibrosis, and the ferroptosis has emerged as pivotal mechanism to achieve this inhibition. The effects naringenin, flavonoid with anti-inflammatory properties, have not been thoroughly examined in fibrosis. Therefore, we used cholestasis model study effect naringenin on Our findings demonstrated significant exacerbation tissue damage fibrosis mice subjected bile duct ligation (BDL), accompanied by substantial upregulation fibrogenesis-related gene expression. Notably, administration markedly alleviated injury these mice. Furthermore, exhibited inhibitory activation HSCs, concurrently inducing ferroptosis. Importantly, significantly increased autophagic activity HSCs. This was counteracted co-administration autophagy inhibitor 3-MA, leading notable reduction naringenin-induced HSC In BDL mice, mitigating suggesting potential correlation These results provide novel insights into molecular mechanisms highlight autophagy-dependent therapeutic strategy
Язык: Английский
Процитировано
6Microchimica Acta, Год журнала: 2024, Номер 191(10)
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
5Toxicology, Год журнала: 2024, Номер 508, С. 153923 - 153923
Опубликована: Авг. 13, 2024
Язык: Английский
Процитировано
4Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 135952 - 135952
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
3Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
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